κ-Opioid agonist inhibits phospholipase C, possibly via an inhibition of G-protein activity

Hidemi Misawa, Hiroshi Ueda, Masamichi Satoh

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

In synaptic membranes of guinea pig cerebellum, in which preparations U-50, 488H, a κ-opioid agonist inhibits G-protein activity, the same κ-agonist at 100 nM inhibited the phospholipase C (PLC) activity stimulated by 100 μM GTP in the presence of 10 μM Ca2+. The present study provides a unique hypothetical mechanism that the receptor-mediated inhibition of PLC is mediated by inhibition of G-protein activity.

Original languageEnglish
Pages (from-to)324-327
Number of pages4
JournalNeuroscience Letters
Volume112
Issue number2-3
DOIs
Publication statusPublished - 1990 May 4
Externally publishedYes

Keywords

  • GTP-binding protein
  • Phospholipase C
  • κ-Opioid receptor

ASJC Scopus subject areas

  • Neuroscience(all)

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