多発性硬化症の治療史と将来展望

Translated title of the contribution: History and prospects of multiple sclerosis treatment

Research output: Contribution to journalArticlepeer-review

Abstract

Multiple sclerosis (MS) is a demyelinating disease of the central nervous system of unknown etiology. Based on a hypothesis that MS is caused by certain viral infections, the efficacy of interferon β was examined in patients and it became the first disease-modifying drug (DMD) approximately 30 years ago. Through the series of research utilizing experimental autoimmune encephalomyelitis, many other DMDs were later developed. With emerging insights on limitation of the animal model, newer treatment strategies are being developed based on pathological findings from MS patients. In the current article, the history of MS treatment and its future prospects will be reviewed and discussed.

Translated title of the contributionHistory and prospects of multiple sclerosis treatment
Original languageJapanese
Pages (from-to)517-523
Number of pages7
JournalClinical Neurology
Volume62
Issue number7
DOIs
Publication statusPublished - 2022

ASJC Scopus subject areas

  • Clinical Neurology

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