12′-Hydroxyl group remarkably reduces Roridin E cytotoxicity

Taiko Oda, Jinzhong Xu, Kazuyo Ukai, Takahiro Nakazawa, Michio Namikoshi

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

Roridin E is a well-known macrocyclic trichothecene mycotoxin possessing potent antiproliferative activity against cancer cell lines. 12′-Hydroxyroridin E was isolated from a marine-derived fungus, Myrothecium roridum 98F42. The cytotoxicities of these two compounds were tested against human monocytic THP-1, human promyelocytic leukemia HL-60, and Chinese hamster V79 cells, and roridin E exhibited more than 1000-fold stronger cytotoxicity than its 12′-OH derivative; therefore, it was suggested that the 12′-position is closely involved in the cytotoxicity of these compounds.

Original languageEnglish
Pages (from-to)317-320
Number of pages4
JournalMycoscience
Volume51
Issue number4
DOIs
Publication statusPublished - 2010 Jan 1

Keywords

  • 12′-Hydroxyroridin E
  • HL-60
  • Marine-derived fungus
  • Myrothecium roridum
  • THP-1

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics

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