1/f fluctuation and water permeation of aquaporins

Research output: Contribution to journalArticle

Abstract

Aquaporins (AQPs) are transmembrane water channels that exclusively transport water molecules across the plasma membranes. Using all-atom molecular dynamics simulations for a system of AQP1/water molecules/lipid bilayer, we investigated the effects of conformational fluctuations of amino acids on water pemeation within AQP1. We found that the amino acids exhibit 1/f fluctuations, indicating possession of long-term memory. In this case, water molecules crossing the ar/R region obey a non-Poisson process. Moreover, we performed restrained MD simulations of AQP1. In restrained MD simulations, the fluctuations of amino acids show white Gaussian fluctuation, and water molecules crossing the ar/R region obey a Poisson process. These results suggest that 1/f fluctuations of amino acids generate the non-Poisson water permeation within AQP1.

Original languageEnglish
Pages (from-to)175-176
Number of pages2
JournalKobunshi
Volume65
Issue number4
Publication statusPublished - 2016 Apr 1

Fingerprint

Aquaporins
Permeation
Water
Amino acids
Amino Acids
Molecules
Lipid bilayers
Cell membranes
Molecular dynamics
Data storage equipment
Atoms
Computer simulation

Keywords

  • 1/f fluctuation
  • Aquaporin
  • Cell Membrane
  • Molecular Dynamics Simulation
  • Non-Poisson Process
  • Water Molecules

ASJC Scopus subject areas

  • Chemical Engineering(all)

Cite this

1/f fluctuation and water permeation of aquaporins. / Yamamoto, Eiji; Yasuoka, Kenji.

In: Kobunshi, Vol. 65, No. 4, 01.04.2016, p. 175-176.

Research output: Contribution to journalArticle

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