Artificial intercalator-carbohydrate hybrids such as that shown in the scheme cleave DNA at the site of guanine on irradiation with UV light with a long wavelength. The hybrids also exhibit strong cytotoxicity when irradiated. The hybrid system is very important for DNA cleavage, and the cytotoxic activity correlates with the DNA-cleaving capacity.
|Number of pages||3|
|Journal||Angewandte Chemie - International Edition|
|Publication status||Published - 1999 Dec 16|
- Antitumor agents
- DNA cleavage
ASJC Scopus subject areas