2-Phenylquinoline-carbohydrate hybrids

Molecular design, chemical synthesis, and evaluation of a new family of light-activatable DNA-cleaving agents

Kazunobu Toshima, Ryusuke Takano, Yutaka Maeda, Masataka Suzuki, Akira Asai, Shuichi Matsumura

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

Artificial intercalator-carbohydrate hybrids such as that shown in the scheme cleave DNA at the site of guanine on irradiation with UV light with a long wavelength. The hybrids also exhibit strong cytotoxicity when irradiated. The hybrid system is very important for DNA cleavage, and the cytotoxic activity correlates with the DNA-cleaving capacity.

Original languageEnglish
Pages (from-to)3733-3735
Number of pages3
JournalAngewandte Chemie - International Edition
Volume38
Issue number24
DOIs
Publication statusPublished - 1999 Dec 16

Fingerprint

Carbohydrates
DNA
Intercalating Agents
Guanine
Cytotoxicity
Hybrid systems
Ultraviolet radiation
Irradiation
Wavelength
2-phenylquinoline

Keywords

  • Antitumor agents
  • Carbohydrates
  • Cytotoxicity
  • DNA cleavage

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

2-Phenylquinoline-carbohydrate hybrids : Molecular design, chemical synthesis, and evaluation of a new family of light-activatable DNA-cleaving agents. / Toshima, Kazunobu; Takano, Ryusuke; Maeda, Yutaka; Suzuki, Masataka; Asai, Akira; Matsumura, Shuichi.

In: Angewandte Chemie - International Edition, Vol. 38, No. 24, 16.12.1999, p. 3733-3735.

Research output: Contribution to journalArticle

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