2-Phenylquinoline-carbohydrate hybrids: Molecular design, chemical synthesis, and evaluation of a new family of light-activatable DNA-cleaving agents

Kazunobu Toshima; Ryusuke Takano; Yutaka Maeda; Masataka Suzuki; Akira Asai; Shuichi Matsumura

doi:10.1002/(SICI)1521-3773(19991216)38:24<3733::AID-ANIE3733>3.0.CO;2-W

2-Phenylquinoline-carbohydrate hybrids: Molecular design, chemical synthesis, and evaluation of a new family of light-activatable DNA-cleaving agents

Kazunobu Toshima, Ryusuke Takano, Yutaka Maeda, Masataka Suzuki, Akira Asai, Shuichi Matsumura

Department of Applied Chemistry

Research output: Contribution to journal › Article › peer-review

40 Citations (Scopus)

Abstract

Artificial intercalator-carbohydrate hybrids such as that shown in the scheme cleave DNA at the site of guanine on irradiation with UV light with a long wavelength. The hybrids also exhibit strong cytotoxicity when irradiated. The hybrid system is very important for DNA cleavage, and the cytotoxic activity correlates with the DNA-cleaving capacity.

Original language	English
Pages (from-to)	3733-3735
Number of pages	3
Journal	Angewandte Chemie - International Edition
Volume	38
Issue number	24
DOIs	https://doi.org/10.1002/(SICI)1521-3773(19991216)38:24<3733::AID-ANIE3733>3.0.CO;2-W
Publication status	Published - 1999 Dec 16

Keywords

Antitumor agents
Carbohydrates
Cytotoxicity
DNA cleavage

ASJC Scopus subject areas

Catalysis
Chemistry(all)

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10.1002/(SICI)1521-3773(19991216)38:24<3733::AID-ANIE3733>3.0.CO;2-W

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Toshima, K., Takano, R., Maeda, Y., Suzuki, M., Asai, A., & Matsumura, S. (1999). 2-Phenylquinoline-carbohydrate hybrids: Molecular design, chemical synthesis, and evaluation of a new family of light-activatable DNA-cleaving agents. Angewandte Chemie - International Edition, 38(24), 3733-3735. https://doi.org/10.1002/(SICI)1521-3773(19991216)38:24<3733::AID-ANIE3733>3.0.CO;2-W

Toshima, K, Takano, R, Maeda, Y, Suzuki, M, Asai, A & Matsumura, S 1999, '2-Phenylquinoline-carbohydrate hybrids: Molecular design, chemical synthesis, and evaluation of a new family of light-activatable DNA-cleaving agents', Angewandte Chemie - International Edition, vol. 38, no. 24, pp. 3733-3735. https://doi.org/10.1002/(SICI)1521-3773(19991216)38:24<3733::AID-ANIE3733>3.0.CO;2-W

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AU - Maeda, Yutaka

AU - Suzuki, Masataka

AU - Asai, Akira

AU - Matsumura, Shuichi

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2-Phenylquinoline-carbohydrate hybrids: Molecular design, chemical synthesis, and evaluation of a new family of light-activatable DNA-cleaving agents

Abstract

Keywords

ASJC Scopus subject areas

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