2-Phenylquinoline-carbohydrate hybrids: Molecular design, chemical synthesis, and evaluation of a new family of light-activatable DNA-cleaving agents

Kazunobu Toshima, Ryusuke Takano, Yutaka Maeda, Masataka Suzuki, Akira Asai, Shuichi Matsumura

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

Artificial intercalator-carbohydrate hybrids such as that shown in the scheme cleave DNA at the site of guanine on irradiation with UV light with a long wavelength. The hybrids also exhibit strong cytotoxicity when irradiated. The hybrid system is very important for DNA cleavage, and the cytotoxic activity correlates with the DNA-cleaving capacity.

Original languageEnglish
Pages (from-to)3733-3735
Number of pages3
JournalAngewandte Chemie - International Edition
Volume38
Issue number24
DOIs
Publication statusPublished - 1999 Dec 16

Keywords

  • Antitumor agents
  • Carbohydrates
  • Cytotoxicity
  • DNA cleavage

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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