2-Phenylquinoline–Sugar Hybrids as Photoswitchable α-Glucosidase Inhibitors

Takashi Kitamura, Mai Okuyama, Daisuke Takahashi, Kazunobu Toshima

Research output: Contribution to journalArticle

Abstract

Purpose-designed 2-phenylquinoline (PQ)-sugar hybrids 1 and 2 were synthesized and evaluated for their photodegradation activities against an α-glucosidase target. The results indicated that PQ-mannose hybrid 2 selectively and effectively photodegraded α-glucosidase and significantly inhibited its enzymatic activity upon irradiation with long-wavelength UV light in the absence of any additives under neutral and aqueous conditions. Furthermore, 2 selectively and effectively inhibited α-glucosidase activity only with photo-irradiation even in complex cell lysate.

Original languageEnglish
JournalChemistry - An Asian Journal
DOIs
Publication statusPublished - 2019 Jan 1

Fingerprint

Glucosidases
Irradiation
Photolysis
Photodegradation
Ultraviolet Rays
Mannose
Sugars
Ultraviolet radiation
Wavelength
2-phenylquinoline

Keywords

  • 2-phenylquinoline
  • C-glycosides
  • hydrolases
  • photodegradation
  • α-glucosidase

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry

Cite this

2-Phenylquinoline–Sugar Hybrids as Photoswitchable α-Glucosidase Inhibitors. / Kitamura, Takashi; Okuyama, Mai; Takahashi, Daisuke; Toshima, Kazunobu.

In: Chemistry - An Asian Journal, 01.01.2019.

Research output: Contribution to journalArticle

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