2016 guidelines for the management of thyroid storm from the Japan thyroid association and Japan endocrine society (First edition)

The Japan thyroid association and Japan endocrine society taskforce committee for the establishment of diagnostic criteria and nationwide surveys for thyroid storm

Tetsurou Satoh, Osamu Isozaki, Atsushi Suzuki, Shu Wakino, Tadao Iburi, Kumiko Tsuboi, Naotetsu Kanamoto, Hajime Otani, Yasushi Furukawa, Satoshi Teramukai, Takashi Akamizu

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Thyroid storm is an endocrine emergency which is characterized by multiple organ failure due to severe thyrotoxicosis, often associated with triggering illnesses. Early suspicion, prompt diagnosis and intensive treatment will improve survival in thyroid storm patients. Because of its rarity and high mortality, prospective intervention studies for the treatment of thyroid storm are difficult to carry out. We, the Japan Thyroid Association and Japan Endocrine Society taskforce committee, previously developed new diagnostic criteria and conducted nationwide surveys for thyroid storm in Japan. Detailed analyses of clinical data from 356 patients revealed that the mortality in Japan was still high (~11%) and that multiple organ failure and acute heart failure were common causes of death. In addition, multimodal treatment with antithyroid drugs, inorganic iodide, corticosteroids and beta-adrenergic antagonists has been suggested to improve mortality of these patients. Based on the evidence obtained by nationwide surveys and additional literature searches, we herein established clinical guidelines for the management of thyroid storm. The present guideline includes 15 recommendations for the treatment of thyrotoxicosis and organ failure in the central nervous system, cardiovascular system, and hepato-gastrointestinal tract, admission criteria for the intensive care unit, and prognostic evaluation. We also proposed preventive approaches to thyroid storm, roles of definitive therapy, and future prospective trial plans for the treatment of thyroid storm. We hope that this guideline will be useful for many physicians all over the world as well as in Japan in the management of thyroid storm and the improvement of its outcome.

Original languageEnglish
Pages (from-to)1025-1064
Number of pages40
JournalEndocrine Journal
Volume63
Issue number12
DOIs
Publication statusPublished - 2016

Fingerprint

Thyroid Crisis
Japan
Thyroid Gland
Guidelines
Thyrotoxicosis
Multiple Organ Failure
Mortality
Therapeutics
Antithyroid Agents
Combined Modality Therapy
Adrenergic beta-Antagonists
Surveys and Questionnaires
Iodides
Cardiovascular System
Intensive Care Units
Gastrointestinal Tract
Cause of Death
Adrenal Cortex Hormones
Emergencies
Central Nervous System

Keywords

  • Diagnostic criteria
  • Prevention
  • Prognosis assessment
  • Thyroid crisis
  • Thyrotoxicosis

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

2016 guidelines for the management of thyroid storm from the Japan thyroid association and Japan endocrine society (First edition) : The Japan thyroid association and Japan endocrine society taskforce committee for the establishment of diagnostic criteria and nationwide surveys for thyroid storm. / Satoh, Tetsurou; Isozaki, Osamu; Suzuki, Atsushi; Wakino, Shu; Iburi, Tadao; Tsuboi, Kumiko; Kanamoto, Naotetsu; Otani, Hajime; Furukawa, Yasushi; Teramukai, Satoshi; Akamizu, Takashi.

In: Endocrine Journal, Vol. 63, No. 12, 2016, p. 1025-1064.

Research output: Contribution to journalArticle

Satoh, Tetsurou ; Isozaki, Osamu ; Suzuki, Atsushi ; Wakino, Shu ; Iburi, Tadao ; Tsuboi, Kumiko ; Kanamoto, Naotetsu ; Otani, Hajime ; Furukawa, Yasushi ; Teramukai, Satoshi ; Akamizu, Takashi. / 2016 guidelines for the management of thyroid storm from the Japan thyroid association and Japan endocrine society (First edition) : The Japan thyroid association and Japan endocrine society taskforce committee for the establishment of diagnostic criteria and nationwide surveys for thyroid storm. In: Endocrine Journal. 2016 ; Vol. 63, No. 12. pp. 1025-1064.
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