TY - JOUR
T1 - 2,2′-Pyridoin derivatives protect HL-60 cells against oxidative stress
AU - Hatanaka, Masashi
AU - Nishizawa, Chiho
AU - Kakinoki, Tomohiro
AU - Takahashi, Kyoko
AU - Nakamura, Shigeo
AU - Mashino, Tadahiko
N1 - Funding Information:
We are greatly thankful to Professor Tadashi Kasahara for providing the HL-60 cells and technical instructions. This work was supported by Academic Frontier Project for Private Universities (2006–2010): matching fund subsidy from MEXT (Ministry of Education, Culture, Sports, Science and Technology).
PY - 2008/10/1
Y1 - 2008/10/1
N2 - Focusing on 2,2′-pyridoin (1, 1,2-di(2-pyridyl)-1,2-ethenediol) and its synthetic derivatives as the lead compound of the potent antioxidative enediol, their protective effect against oxidative stress was evaluated on the HL-60 cell system. 2,2′-Pyridoins showed no remarkable cytotoxic effect on HL-60 cells. The derivatives 1, 2, 3, 5, and 6 inhibited H2O2-induced cell death and intracellular oxidative stress more significantly than ascorbic acid. Since 2,2′-pyridoins are oxidized to the diketones, 2,2′-pyridils, in a protic solvent, the antioxidant activity of 2,2′-pyridils was also investigated. 2,2′-Pyridils showed antioxidant activity in the cell; however, the activity was lower than that of 2,2′-pyridoins. These results suggested that 2,2′-pyrdoin derivatives can be good cytoprotective agents against oxidative stress.
AB - Focusing on 2,2′-pyridoin (1, 1,2-di(2-pyridyl)-1,2-ethenediol) and its synthetic derivatives as the lead compound of the potent antioxidative enediol, their protective effect against oxidative stress was evaluated on the HL-60 cell system. 2,2′-Pyridoins showed no remarkable cytotoxic effect on HL-60 cells. The derivatives 1, 2, 3, 5, and 6 inhibited H2O2-induced cell death and intracellular oxidative stress more significantly than ascorbic acid. Since 2,2′-pyridoins are oxidized to the diketones, 2,2′-pyridils, in a protic solvent, the antioxidant activity of 2,2′-pyridils was also investigated. 2,2′-Pyridils showed antioxidant activity in the cell; however, the activity was lower than that of 2,2′-pyridoins. These results suggested that 2,2′-pyrdoin derivatives can be good cytoprotective agents against oxidative stress.
KW - Antioxidant
KW - Cytoprotective effect
KW - Pyridoin
KW - Radical scavenger
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U2 - 10.1016/j.bmcl.2008.08.057
DO - 10.1016/j.bmcl.2008.08.057
M3 - Article
C2 - 18790639
AN - SCOPUS:52049107620
SN - 0960-894X
VL - 18
SP - 5290
EP - 5293
JO - Bioorganic and Medicinal Chemistry Letters
JF - Bioorganic and Medicinal Chemistry Letters
IS - 19
ER -