2,2′-Pyridoin derivatives protect HL-60 cells against oxidative stress

Masashi Hatanaka, Chiho Nishizawa, Tomohiro Kakinoki, Kyoko Takahashi, Shigeo Nakamura, Tadahiko Mashino

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Focusing on 2,2′-pyridoin (1, 1,2-di(2-pyridyl)-1,2-ethenediol) and its synthetic derivatives as the lead compound of the potent antioxidative enediol, their protective effect against oxidative stress was evaluated on the HL-60 cell system. 2,2′-Pyridoins showed no remarkable cytotoxic effect on HL-60 cells. The derivatives 1, 2, 3, 5, and 6 inhibited H2O2-induced cell death and intracellular oxidative stress more significantly than ascorbic acid. Since 2,2′-pyridoins are oxidized to the diketones, 2,2′-pyridils, in a protic solvent, the antioxidant activity of 2,2′-pyridils was also investigated. 2,2′-Pyridils showed antioxidant activity in the cell; however, the activity was lower than that of 2,2′-pyridoins. These results suggested that 2,2′-pyrdoin derivatives can be good cytoprotective agents against oxidative stress.

Original languageEnglish
Pages (from-to)5290-5293
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume18
Issue number19
DOIs
Publication statusPublished - 2008 Oct 1

Fingerprint

Oxidative stress
HL-60 Cells
Oxidative Stress
Derivatives
Antioxidants
Lead compounds
Cell death
Ascorbic Acid
Cell Death

Keywords

  • Antioxidant
  • Cytoprotective effect
  • Pyridoin
  • Radical scavenger

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science
  • Medicine(all)

Cite this

2,2′-Pyridoin derivatives protect HL-60 cells against oxidative stress. / Hatanaka, Masashi; Nishizawa, Chiho; Kakinoki, Tomohiro; Takahashi, Kyoko; Nakamura, Shigeo; Mashino, Tadahiko.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 18, No. 19, 01.10.2008, p. 5290-5293.

Research output: Contribution to journalArticle

Hatanaka, Masashi ; Nishizawa, Chiho ; Kakinoki, Tomohiro ; Takahashi, Kyoko ; Nakamura, Shigeo ; Mashino, Tadahiko. / 2,2′-Pyridoin derivatives protect HL-60 cells against oxidative stress. In: Bioorganic and Medicinal Chemistry Letters. 2008 ; Vol. 18, No. 19. pp. 5290-5293.
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