3-Acetoxy-2,2′-bi-1H-indol as a novel inhibitor of ATP binding to DnaA, the protein initiating chromosomal replication in escherichia coli

Shigeki Sasaki, Tohru Mizushima, Tomohiro Hashimoto, Minoru Maeda, Sekimizu Kazuhisa

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)

Abstract

3-Acetoxy-2,2′-bi-1H-indol which is derived from indigo was found to be a novel and potent inhibitor of ATP binding (IC50=0.04mM) to DnaA protein, a key protein in the initiation of chromosomal DNA replication in Escherichia coli. Competitive experiments indicated the inhibition to be non-competitive with ATP.

Original languageEnglish
Pages (from-to)1771-1774
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume4
Issue number14
DOIs
Publication statusPublished - 1994 Jul 21

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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