3-Acetoxy-2,2′-bi-1H-indol as a novel inhibitor of ATP binding to DnaA, the protein initiating chromosomal replication in escherichia coli

Shigeki Sasaki; Tohru Mizushima; Tomohiro Hashimoto; Minoru Maeda; Sekimizu Kazuhisa

doi:10.1016/S0960-894X(00)80378-9

3-Acetoxy-2,2′-bi-1H-indol as a novel inhibitor of ATP binding to DnaA, the protein initiating chromosomal replication in escherichia coli

Shigeki Sasaki, Tohru Mizushima, Tomohiro Hashimoto, Minoru Maeda, Sekimizu Kazuhisa

School of Pharmacy

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

3-Acetoxy-2,2′-bi-1H-indol which is derived from indigo was found to be a novel and potent inhibitor of ATP binding (IC₅₀=0.04mM) to DnaA protein, a key protein in the initiation of chromosomal DNA replication in Escherichia coli. Competitive experiments indicated the inhibition to be non-competitive with ATP.

Original language	English
Pages (from-to)	1771-1774
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	4
Issue number	14
DOIs	https://doi.org/10.1016/S0960-894X(00)80378-9
Publication status	Published - 1994 Jul 21

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/S0960-894X(00)80378-9

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abstract = "3-Acetoxy-2,2′-bi-1H-indol which is derived from indigo was found to be a novel and potent inhibitor of ATP binding (IC50=0.04mM) to DnaA protein, a key protein in the initiation of chromosomal DNA replication in Escherichia coli. Competitive experiments indicated the inhibition to be non-competitive with ATP.",

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AU - Sasaki, Shigeki

AU - Mizushima, Tohru

AU - Hashimoto, Tomohiro

AU - Maeda, Minoru

AU - Kazuhisa, Sekimizu

PY - 1994/7/21

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AB - 3-Acetoxy-2,2′-bi-1H-indol which is derived from indigo was found to be a novel and potent inhibitor of ATP binding (IC50=0.04mM) to DnaA protein, a key protein in the initiation of chromosomal DNA replication in Escherichia coli. Competitive experiments indicated the inhibition to be non-competitive with ATP.

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3-Acetoxy-2,2′-bi-1H-indol as a novel inhibitor of ATP binding to DnaA, the protein initiating chromosomal replication in escherichia coli

Abstract

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