3-compartment talaporfin sodium pharmacokinetic model by optimization using fluorescence measurement data from canine skin to estimate the concentration in interstitial space

Yuko Uno, Emiyu Ogawa, Eitaro Aiyoshi, Tsunenori Arai

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

We constructed the 3-compartment talaporfin sodium pharmacokinetic model for canine by an optimization using the fluorescence measurement data from canine skin to estimate the concentration in the interstitial space. It is difficult to construct the 3-compartment model consisted of plasma, interstitial space, and cell because there is a lack of the dynamic information. Therefore, we proposed the methodology to construct the 3-compartment model using the measured talaporfin sodium skin fluorescence change considering originated tissue part by a histological observation. In a canine animal experiment, the talaporfin sodium concentration time history in plasma was measured by a spectrophotometer with a prepared calibration curve. The time history of talaporfin sodium Q-band fluorescence on left femoral skin of a beagle dog excited by talaporfin sodium Soret-band of 409 nm was measured in vivo by our previously constructed measurement system. The measured skin fluorescence was classified to its source, that is, specific ratio of plasma, interstitial space, and cell. We represented differential rate equations of the talaporfin sodium concentration in plasma, interstitial space, cell. The specific ratios and a converting constant to obtain absolute value of skin concentration were arranged. Minimizing the squared error of the difference between the measured fluorescence data and calculated concentration by the conjugate gradient method in MATLAB, the rate constants in the 3-compartment model were determined. The accuracy of the fitting operation was confirmed with determination coefficient of 0.98. We could construct the 3-compartment pharmacokinetic model for canine using the measured talaporfin sodium fluorescence change from canine skin.

LanguageEnglish
Title of host publicationOptical Methods for Tumor Treatment and Detection
Subtitle of host publicationMechanisms and Techniques in Photodynamic Therapy XXVII
PublisherSPIE
Volume10476
ISBN (Electronic)9781510614376
DOIs
Publication statusPublished - 2018 Jan 1
EventOptical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXVII 2018 - San Francisco, United States
Duration: 2018 Jan 272018 Jan 29

Other

OtherOptical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXVII 2018
CountryUnited States
CitySan Francisco
Period18/1/2718/1/29

Fingerprint

Pharmacokinetics
compartments
Canidae
Skin
interstitials
Fluorescence
Sodium
sodium
fluorescence
optimization
estimates
Plasmas
cells
histories
conjugate gradient method
Conjugate gradient method
dogs
Spectrophotometers
spectrophotometers
Thigh

Keywords

  • 3-compartment model
  • interstitial space
  • pharmacokinetics
  • talaporfin sodium

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging

Cite this

Uno, Y., Ogawa, E., Aiyoshi, E., & Arai, T. (2018). 3-compartment talaporfin sodium pharmacokinetic model by optimization using fluorescence measurement data from canine skin to estimate the concentration in interstitial space. In Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXVII (Vol. 10476). [1047611] SPIE. https://doi.org/10.1117/12.2289199

3-compartment talaporfin sodium pharmacokinetic model by optimization using fluorescence measurement data from canine skin to estimate the concentration in interstitial space. / Uno, Yuko; Ogawa, Emiyu; Aiyoshi, Eitaro; Arai, Tsunenori.

Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXVII. Vol. 10476 SPIE, 2018. 1047611.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Uno, Y, Ogawa, E, Aiyoshi, E & Arai, T 2018, 3-compartment talaporfin sodium pharmacokinetic model by optimization using fluorescence measurement data from canine skin to estimate the concentration in interstitial space. in Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXVII. vol. 10476, 1047611, SPIE, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXVII 2018, San Francisco, United States, 18/1/27. https://doi.org/10.1117/12.2289199
Uno Y, Ogawa E, Aiyoshi E, Arai T. 3-compartment talaporfin sodium pharmacokinetic model by optimization using fluorescence measurement data from canine skin to estimate the concentration in interstitial space. In Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXVII. Vol. 10476. SPIE. 2018. 1047611 https://doi.org/10.1117/12.2289199
Uno, Yuko ; Ogawa, Emiyu ; Aiyoshi, Eitaro ; Arai, Tsunenori. / 3-compartment talaporfin sodium pharmacokinetic model by optimization using fluorescence measurement data from canine skin to estimate the concentration in interstitial space. Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXVII. Vol. 10476 SPIE, 2018.
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