(-)-(3S)-4-(2-{[4,4-Dimethoxy-6-(benzyloxymethyl)perhydropyran-2-yl]methyl}-1,3-dithian-2-yl)-4-methyl-3-(1,1,2,2-tetramethyl-1-silapropoxy)- Pentan-1-ol

Hiroyuki Hosomi; Shigeru Ohba; Ken Ohmori; Tetsuo Obitsu; Yasuyuki Ogawa; Yuichi Ishikawa; Shosuke Yamamura; Shigeru Nishiyama

doi:10.1107/S010827010000336X

(-)-(3S)-4-(2-{[4,4-Dimethoxy-6-(benzyloxymethyl)perhydropyran-2-yl]methyl}-1,3-dithian-2-yl)-4-methyl-3-(1,1,2,2-tetramethyl-1-silapropoxy)- Pentan-1-ol

Hiroyuki Hosomi, Shigeru Ohba, Ken Ohmori, Tetsuo Obitsu, Yasuyuki Ogawa, Yuichi Ishikawa, Shosuke Yamamura, Shigeru Nishiyama

Department of Humanities and Social Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

The absolute configuration of (-)-(3S)-4-(2-{[4,4-Dimethoxy-6-(benzyloxymethyl)perhydropyran-2-yl]methyl}-1,3-dithian-2-yl)-4-methyl-3-(1,1,2,2-tetramethyl-1-silapropoxy)-pentan-1-ol was determined, and it was prepared in a synthetic study concerning the natural products bryostatins. It was observed that two independent molecules showed similar conformations, except for the orientation of the methoxy groups. The absolute structure of the compound was determined based on a Flack parameter value of 0.0 (1), which was consistent with the expected absolute configuration of 3S produced by Sharpless asymmetric epoxidation protcol.

Original language	English
Pages (from-to)	e140-e141
Journal	Acta Crystallographica Section C: Crystal Structure Communications
Volume	56
Issue number	4
DOIs	https://doi.org/10.1107/S010827010000336X
Publication status	Published - 2000

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

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Hosomi, H., Ohba, S., Ohmori, K., Obitsu, T., Ogawa, Y., Ishikawa, Y., Yamamura, S., & Nishiyama, S. (2000). (-)-(3S)-4-(2-{[4,4-Dimethoxy-6-(benzyloxymethyl)perhydropyran-2-yl]methyl}-1,3-dithian-2-yl)-4-methyl-3-(1,1,2,2-tetramethyl-1-silapropoxy)- Pentan-1-ol. Acta Crystallographica Section C: Crystal Structure Communications, 56(4), e140-e141. https://doi.org/10.1107/S010827010000336X

(-)-(3S)-4-(2-{[4,4-Dimethoxy-6-(benzyloxymethyl)perhydropyran-2-yl]methyl}-1,3-dithian-2-yl)-4-methyl-3-(1,1,2,2-tetramethyl-1-silapropoxy)- Pentan-1-ol. / Hosomi, Hiroyuki; Ohba, Shigeru; Ohmori, Ken et al.

In: Acta Crystallographica Section C: Crystal Structure Communications, Vol. 56, No. 4, 2000, p. e140-e141.

Research output: Contribution to journal › Article › peer-review

Hosomi, H, Ohba, S, Ohmori, K, Obitsu, T, Ogawa, Y, Ishikawa, Y, Yamamura, S & Nishiyama, S 2000, '(-)-(3S)-4-(2-{[4,4-Dimethoxy-6-(benzyloxymethyl)perhydropyran-2-yl]methyl}-1,3-dithian-2-yl)-4-methyl-3-(1,1,2,2-tetramethyl-1-silapropoxy)- Pentan-1-ol', Acta Crystallographica Section C: Crystal Structure Communications, vol. 56, no. 4, pp. e140-e141. https://doi.org/10.1107/S010827010000336X

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title = "(-)-(3S)-4-(2-{[4,4-Dimethoxy-6-(benzyloxymethyl)perhydropyran-2-yl]methyl}-1,3-dithian-2-yl)-4-methyl-3-(1,1,2,2-tetramethyl-1-silapropoxy)- Pentan-1-ol",

abstract = "The absolute configuration of (-)-(3S)-4-(2-{[4,4-Dimethoxy-6-(benzyloxymethyl)perhydropyran-2-yl]methyl}-1,3-dithian-2-yl)-4-methyl-3-(1,1,2,2-tetramethyl-1-silapropoxy)-pentan-1-ol was determined, and it was prepared in a synthetic study concerning the natural products bryostatins. It was observed that two independent molecules showed similar conformations, except for the orientation of the methoxy groups. The absolute structure of the compound was determined based on a Flack parameter value of 0.0 (1), which was consistent with the expected absolute configuration of 3S produced by Sharpless asymmetric epoxidation protcol.",

author = "Hiroyuki Hosomi and Shigeru Ohba and Ken Ohmori and Tetsuo Obitsu and Yasuyuki Ogawa and Yuichi Ishikawa and Shosuke Yamamura and Shigeru Nishiyama",

year = "2000",

doi = "10.1107/S010827010000336X",

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volume = "56",

pages = "e140--e141",

journal = "Acta Crystallographica Section C: Crystal Structure Communications",

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publisher = "International Union of Crystallography",

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T1 - (-)-(3S)-4-(2-{[4,4-Dimethoxy-6-(benzyloxymethyl)perhydropyran-2-yl]methyl}-1,3-dithian-2-yl)-4-methyl-3-(1,1,2,2-tetramethyl-1-silapropoxy)- Pentan-1-ol

AU - Hosomi, Hiroyuki

AU - Ohba, Shigeru

AU - Ohmori, Ken

AU - Obitsu, Tetsuo

AU - Ogawa, Yasuyuki

AU - Ishikawa, Yuichi

AU - Yamamura, Shosuke

AU - Nishiyama, Shigeru

PY - 2000

Y1 - 2000

N2 - The absolute configuration of (-)-(3S)-4-(2-{[4,4-Dimethoxy-6-(benzyloxymethyl)perhydropyran-2-yl]methyl}-1,3-dithian-2-yl)-4-methyl-3-(1,1,2,2-tetramethyl-1-silapropoxy)-pentan-1-ol was determined, and it was prepared in a synthetic study concerning the natural products bryostatins. It was observed that two independent molecules showed similar conformations, except for the orientation of the methoxy groups. The absolute structure of the compound was determined based on a Flack parameter value of 0.0 (1), which was consistent with the expected absolute configuration of 3S produced by Sharpless asymmetric epoxidation protcol.

AB - The absolute configuration of (-)-(3S)-4-(2-{[4,4-Dimethoxy-6-(benzyloxymethyl)perhydropyran-2-yl]methyl}-1,3-dithian-2-yl)-4-methyl-3-(1,1,2,2-tetramethyl-1-silapropoxy)-pentan-1-ol was determined, and it was prepared in a synthetic study concerning the natural products bryostatins. It was observed that two independent molecules showed similar conformations, except for the orientation of the methoxy groups. The absolute structure of the compound was determined based on a Flack parameter value of 0.0 (1), which was consistent with the expected absolute configuration of 3S produced by Sharpless asymmetric epoxidation protcol.

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JO - Acta Crystallographica Section C: Crystal Structure Communications

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(-)-(3S)-4-(2-{[4,4-Dimethoxy-6-(benzyloxymethyl)perhydropyran-2-yl]methyl}-1,3-dithian-2-yl)-4-methyl-3-(1,1,2,2-tetramethyl-1-silapropoxy)- Pentan-1-ol

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