(-)-(3S)-4-(2-{[4,4-Dimethoxy-6-(benzyloxymethyl)perhydropyran-2-yl]methyl}-1,3-dithian-2-yl)-4-methyl-3-(1,1,2,2-tetramethyl-1-silapropoxy)- Pentan-1-ol

Hiroyuki Hosomi, Shigeru Ohba, Ken Ohmori, Tetsuo Obitsu, Yasuyuki Ogawa, Yuichi Ishikawa, Shosuke Yamamura, Shigeru Nishiyama

Research output: Contribution to journalArticle

Abstract

The absolute configuration of (-)-(3S)-4-(2-{[4,4-Dimethoxy-6-(benzyloxymethyl)perhydropyran-2-yl]methyl}-1,3-dithian-2-yl)-4-methyl-3-(1,1,2,2-tetramethyl-1-silapropoxy)-pentan-1-ol was determined, and it was prepared in a synthetic study concerning the natural products bryostatins. It was observed that two independent molecules showed similar conformations, except for the orientation of the methoxy groups. The absolute structure of the compound was determined based on a Flack parameter value of 0.0 (1), which was consistent with the expected absolute configuration of 3S produced by Sharpless asymmetric epoxidation protcol.

Original languageEnglish
Pages (from-to)e140-e141
JournalActa Crystallographica Section C: Crystal Structure Communications
Volume56
Issue number4
DOIs
Publication statusPublished - 2000 Jan 1

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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