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• Activation of TNFR1 ectodomain shedding by mitochondrial Ca²⁺ determines the severity of inflammation in mouse lung microvessels

  Rowlands, D. J., Islam, M. N., Das, S. R., Huertas, A., Quadri, S. K., Horiuchi, K., Inamdar, N., Emin, M. T., Lindert, J., Ten, V. S., Bhattacharya, S. & Bhattacharya, J., 2011 May 2, In: Journal of Clinical Investigation. 121, 5, p. 1986-1999 14 p.

  Research output: Contribution to journal › Article › peer-review
  84 Citations (Scopus)

• Activation of the precursor of human stromelysin 2 and its interactions with other matrix metalloproteinases

  Nakamura, H., Fujii, Y., Ohuchi, E., Yamamoto, E. & Okada, Y., 1998 Apr 1, In: European Journal of Biochemistry. 253, 1, p. 67-75 9 p.

  Research output: Contribution to journal › Article › peer-review
  98 Citations (Scopus)

• Activation of the precursor of gelatinase A/72 kDa type IV collagenase/MMP-2 in lung carcinomas correlates with the expression of membrane-type matrix metalloproteinase (MT-MMP) and with lymph node metastasis

  Tokuraku, M., Sato, H., Murakami, S., Okada, Y., Watanabe, Y. & Seiki, M., 1995, In: International Journal of Cancer. 64, 5, p. 355-359 5 p.

  Research output: Contribution to journal › Article › peer-review
  268 Citations (Scopus)

• Activation of the orbitofrontal cortex by both meditation and exercise: A near-infrared spectroscopy study

  Miyashiro, S., Yamada, Y., Muta, T., Ishikawa, H., Abe, T., Hori, M., Oka, K., Koshikawa, F. & Ito, E., 2021 Feb, In: PloS one. 16, 2 February, e0247685.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  4 Citations (Scopus)

• Activation of the intestinal tissue renin-angiotensin systemby transient sodium loading in saltsensitive rats

  Ryuzaki, M., Miyashita, K., Sato, M., Inoue, H., Fujii, K., Hagiwara, A., Uto, A., Endo, S., Oshida, T., Kinouchi, K. & Itoh, H., 2022 Jan 1, In: Journal of hypertension. 40, 1, p. 33-45 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  1 Citation (Scopus)

• Activation of the FGF2-FGFR1 autocrine pathway: A novel mechanism of acquired resistance to gefitinib in NSCLC

  Terai, H., Soejima, K., Yasuda, H., Nakayama, S., Hamamoto, J., Arai, D., Ishioka, K., Ohgino, K., Ikemura, S., Sato, T., Yoda, S., Satomi, R., Naoki, K. & Betsuyaku, T., 2013 Jul, In: Molecular Cancer Research. 11, 7, p. 759-767 9 p.

  Research output: Contribution to journal › Article › peer-review
  161 Citations (Scopus)

• Activation of the aryl hydrocarbon receptor pathway enhances cancer cell invasion by upregulating the MMP expression and is associated with poor prognosis in upper urinary tract urothelial cancer

  Ishida, M., Mikami, S., Kikuchi, E., Kosaka, T., Miyajima, A., Nakagawa, K., Mukai, M., Okada, Y. & Oya, M., 2010 Feb, In: Carcinogenesis. 31, 2, p. 287-295 9 p., bgp222.

  Research output: Contribution to journal › Article › peer-review
  82 Citations (Scopus)

• Activation of the AKT and STAT3 pathways and prolonged survival by a mutant EGFR in human lung cancer cells

  Akca, H., Tani, M., Hishida, T., Matsumoto, S. & Yokota, J., 2006 Oct, In: Lung Cancer. 54, 1, p. 25-33 9 p.

  Research output: Contribution to journal › Article › peer-review
  44 Citations (Scopus)

• Activation of STAT5 by lipopolysaccharide through granulocyte-macrophage colony-stimulating factor production in human monocytes

  Yamaoka, K., Otsuka, T., Niiro, H., Arinobu, Y., Niho, Y., Hamasaki, N. & Izuhara, K., 1998 Jan 15, In: Journal of Immunology. 160, 2, p. 838-845 8 p.

  Research output: Contribution to journal › Article › peer-review
  53 Citations (Scopus)

• Activation of STAT3 by the hepatitis C virus core protein leads to cellular transformation

  Yoshida, T., Hanada, T., Tokuhisa, T., Kosai, K. I., Sata, M., Kohara, M. & Yoshimura, A., 2002 Sep, In: Journal of Experimental Medicine. 196, 5, p. 641-653 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  220 Citations (Scopus)

• Activation of SRC kinase and phosphorylation of signal transducer and activator of transcription-5 are required for decidual transformation of human endometrial stromal cells

  Nagashima, T., Maruyama, T., Uchida, H., Kajitani, T., Arase, T., Ono, M., Oda, H., Kagami, M., Masuda, H., Nishikawa, S., Asada, H. & Yoshimura, Y., 2008 Mar, In: Endocrinology. 149, 3, p. 1227-1234 8 p.

  Research output: Contribution to journal › Article › peer-review
  19 Citations (Scopus)

• Activation of Smad-mediated TGF-β signaling triggers epithelial-mesenchymal transitions in murine cloned corneal progenitor cells

  Kawakita, T., Espana, E. M., Higa, K., Kato, N., Li, W. & Tseng, S. C. G., 2013 Jan, In: Journal of Cellular Physiology. 228, 1, p. 225-234 10 p.

  Research output: Contribution to journal › Article › peer-review
  24 Citations (Scopus)

• Activation of signal transducer and activator of transcription 3 in renal cell carcinoma: A study of incidence and its association with pathological features and clinical outcome

  Horiguchi, A., Oya, M., Shimada, T., Uchida, A., Marumo, K. & Murai, M., 2002, In: Journal of Urology. 168, 2, p. 762-765 4 p.

  Research output: Contribution to journal › Article › peer-review
  139 Citations (Scopus)

• Activation of signal transducer and activator of transcription 3 (Stat3) pathway in osteosarcoma cells and overexpression of phosphorylated-Stat3 correlates with poor prognosis

  Ryu, K., Choy, E., Yang, C., Susa, M., Hornicek, F. J., Mankin, H. & Duan, Z., 2010 Jul, In: Journal of Orthopaedic Research. 28, 7, p. 971-978 8 p.

  Research output: Contribution to journal › Article › peer-review
  71 Citations (Scopus)

• Activation of SF1 neurons in the ventromedial hypothalamus by DREADD technology increases insulin sensitivity in peripheral tissues

  Coutinho, E. A., Okamoto, S., Ishikawa, A. W., Yokota, S., Wada, N., Hirabayashi, T., Saito, K., Sato, T., Takagi, K., Wang, C. C., Kobayashi, K., Ogawa, Y., Shioda, S., Yoshimura, Y. & Minokoshi, Y., 2017 Sep, In: Diabetes. 66, 9, p. 2372-2386 15 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  50 Citations (Scopus)

• Activation of right insular cortex during imaginary speech articulation

  Kato, Y., Muramatsu, T., Kato, M., Shintani, M. & Kashima, H., 2007 Mar 1, In: NeuroReport. 18, 5, p. 505-509 5 p.

  Research output: Contribution to journal › Article › peer-review
  14 Citations (Scopus)

• Activation of right inferior frontal gyrus during response inhibition across response modalities

  Chikazoe, J., Konishi, S., Asari, T., Jimura, K. & Miyashita, Y., 2007 Jan, In: Journal of Cognitive Neuroscience. 19, 1, p. 69-80 12 p.

  Research output: Contribution to journal › Article › peer-review
  214 Citations (Scopus)

• Activation of pyruvate dehydrogenase by dichloroacetate has the potential to induce epigenetic remodeling in the heart

  Matsuhashi, T., Hishiki, T., Zhou, H., Ono, T., Kaneda, R., Iso, T., Yamaguchi, A., Endo, J., Katsumata, Y., Atsushi, A., Yamamoto, T., Shirakawa, K., Yan, X., Shinmura, K., Suematsu, M., Fukuda, K. & Sano, M., 2015 May 1, In: Journal of Molecular and Cellular Cardiology. 82, p. 116-124 9 p.

  Research output: Contribution to journal › Article › peer-review
  29 Citations (Scopus)

• Activation of pro-MMP-2 mediated by MT1-MMP in human salivary gland carcinomas: Possible regulation of pro-MMP-2 activation by TIMP-2

  Kayano, K., Shimada, T., Shinomiya, T., Nakai, S., Hisa, Y., Aoki, T., Seiki, M. & Okada, Y., 2004 Apr 1, In: Journal of Pathology. 202, 4, p. 403-411 9 p.

  Research output: Contribution to journal › Article › peer-review
  31 Citations (Scopus)

• Activation of preformed EGF receptor dimers by ligand-induced rotation of the transmembrane domain

  Moriki, T., Maruyama, H. & Maruyama, I. N., 2001 Aug 31, In: Journal of Molecular Biology. 311, 5, p. 1011-1026 16 p.

  Research output: Contribution to journal › Article › peer-review
  277 Citations (Scopus)

• Activation of peroxisome proliferator-activated receptor δ induces fatty acid β-oxidation in skeletal muscle and attenuates metabolic syndrome

  Tanaka, T., Yamamoto, J., Iwasaki, S., Asaba, H., Hamura, H., Ikeda, Y., Watanabe, M., Magoori, K., Ioka, R. X., Tachibana, K., Watanabe, Y., Uchiyama, Y., Sumi, K., Iguchi, H., Ito, S., Doi, T., Hamakubo, T., Naito, M., Auwerx, J., Yanagisawa, M., & 2 othersKodama, T. & Sakai, J., 2003 Dec 23, In: Proceedings of the National Academy of Sciences of the United States of America. 100, 26, p. 15924-15929 6 p.

  Research output: Contribution to journal › Article › peer-review
  731 Citations (Scopus)

• Activation of NG2-positive oligodendrocyte progenitor cells during post-ischemic reperfusion in the rat brain

  Tanaka, K., Nogawa, S., Ito, D., Suzuki, S., Dembo, T., Kosakai, A. & Fukuuchi, Y., 2001 Jul 20, In: NeuroReport. 12, 10, p. 2169-2174 6 p.

  Research output: Contribution to journal › Article › peer-review
  65 Citations (Scopus)

• Activation of Neutrophil-like Cells Stimulated by Polymer Surfaces

  Fujimoto, K., Sasaki, J., Tomida, Y., Wakabayashi, Y. & Kawaguchi, H., 1998, In: KOBUNSHI RONBUNSHU. 55, 6, p. 367-371 5 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Activation of natural killer T cells by α-galactosylceramide impairs DNA vaccine-induced protective immunity against Trypanosoma cruzi

  Miyahira, Y., Katae, M., Takeda, K., Yagita, H., Okumura, K., Kobayashi, S., Takeuchi, T., Kamiyama, T., Fukuchi, Y. & Aoki, T., 2003 Mar 1, In: Infection and Immunity. 71, 3, p. 1234-1241 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  37 Citations (Scopus)

• Activation of murine cytomegalovirus immediate-early promoter in cerebral ventricular zone and glial progenitor cells in transgenic mice

  Li, R. Y., Baba, S., Kosugi, I., Arai, Y., Kawasaki, H., Shinmura, Y., Sakakibara, S. I., Okano, H. & Tsutsui, Y., 2001, In: Glia. 35, 1, p. 41-52 12 p.

  Research output: Contribution to journal › Article › peer-review
  20 Citations (Scopus)

• Activation of m-Calpain Is Required for Chromosome Alignment on the Metaphase Plate during Mitosis

  Honda, S., Marumoto, T., Hirota, T., Nitta, M., Arima, Y., Ogawa, M. & Saya, H., 2004 Mar 12, In: Journal of Biological Chemistry. 279, 11, p. 10615-10623 9 p.

  Research output: Contribution to journal › Article › peer-review
  36 Citations (Scopus)

• Activation of matrix metalloproteinase 3 (stromelysin) and matrix metalloproteinase 2 ('gelatinase') by human neutrophil elastase and cathepsin G

  Okada, Y. & Nakanishi, I., 1989 Jun 5, In: FEBS Letters. 249, 2, p. 353-356 4 p.

  Research output: Contribution to journal › Article › peer-review
  147 Citations (Scopus)

• Activation of matrix metalloproteinase-2 in head and neck squamous cell carcinoma: Studies of clinical samples and in vitro cell lines co-cultured with fibroblasts

  Tokumaru, Y., Fujii, M., Otani, Y., Kameyama, K., Imanishi, Y., Igarashi, N. & Kanzaki, J., 2000 Mar 13, In: Cancer Letters. 150, 1, p. 15-21 7 p.

  Research output: Contribution to journal › Article › peer-review
  38 Citations (Scopus)

• Activation of JNK triggers release of Brd4 from mitotic chromosomes and mediates protection from drug-induced mitotic stress

  Nishiyama, A., Dey, A., Tamura, T., Ko, M. & Ozato, K., 2012 May 2, In: PloS one. 7, 5, e34719.

  Research output: Contribution to journal › Article › peer-review
  7 Citations (Scopus)

• Activation of human neutrophils by Arg‐Gly‐Asp‐Ser immobilized on microspheres

  Kasuya, Y., Fujimoto, K., Miyamoto, M. & Kawaguchi, H., 1994 Mar, In: Journal of Biomedical Materials Research. 28, 3, p. 397-404 8 p.

  Research output: Contribution to journal › Article › peer-review
  12 Citations (Scopus)

• Activation of heparanase by ultraviolet B irradiation leads to functional loss of basement membrane at the dermal-epidermal junction in human skin

  Iriyama, S., Matsunaga, Y., Takahashi, K., Matsuzaki, K., Kumagai, N. & Amano, S., 2011 May, In: Archives of Dermatological Research. 303, 4, p. 253-261 9 p.

  Research output: Contribution to journal › Article › peer-review
  30 Citations (Scopus)

• Activation of extracellular signal-regulated kinase is associated with hepatocellular carcinoma with aggressive phenotypes

  Minagawa, T., Yamazaki, K., Masugi, Y., Tsujikawa, H., Ojima, H., Hibi, T., Abe, Y., Yagi, H., Kitago, M., Shinoda, M., Itano, O., Kitagawa, Y. & Sakamoto, M., 2020 Mar 1, In: Hepatology Research. 50, 3, p. 353-364 12 p.

  Research output: Contribution to journal › Article › peer-review
  5 Citations (Scopus)

• Activation of extracellular signal-regulated kinase in the trigeminal ganglion following both treatment of the dura mater with capsaicin and cortical spreading depression

  Iwashita, T., Shimizu, T., Shibata, M., Toriumi, H., Ebine, T., Funakubo, M. & Suzuki, N., 2013 Sep, In: Neuroscience Research. 77, 1-2, p. 110-119 10 p.

  Research output: Contribution to journal › Article › peer-review
  20 Citations (Scopus)

• Activation of EGFR bypass signaling by TGFa overexpression induces acquired resistance to alectinib in ALK-translocated lung cancer cells

  Tani, T., Yasuda, H., Hamamoto, J., Kuroda, A., Arai, D., Ishioka, K., Ohgino, K., Miyawaki, M., Kawada, I., Naoki, K., Hayashi, Y., Betsuyaku, T. & Soejima, K., 2016 Jan 1, In: Molecular cancer therapeutics. 15, 1, p. 162-171 10 p.

  Research output: Contribution to journal › Article › peer-review
  44 Citations (Scopus)

• Activation of dendritic-like cells and neural stem/progenitor cells in injured spinal cord by GM-CSF

  Hayashi, K., Ohta, S., Kawakami, Y. & Toda, M., 2009 May, In: Neuroscience Research. 64, 1, p. 96-103 8 p.

  Research output: Contribution to journal › Article › peer-review
  35 Citations (Scopus)

• Activation of cytokine signaling through leukemia inhibitory factor receptor (LIFR)/gp130 attenuates ischemic brain injury in rats

  Suzuki, S., Yamashita, T., Tanaka, K., Hattori, H., Sawamoto, K., Okano, H. & Suzuki, N., 2005 Jun, In: Journal of Cerebral Blood Flow and Metabolism. 25, 6, p. 685-693 9 p.

  Research output: Contribution to journal › Article › peer-review
  44 Citations (Scopus)

• Activation of c-Src kinase is associated with in vitro decidualization of human endometrial stromal cells

  Maruyama, T., Yoshimura, Y., Yodoi, J. & Sabe, H., 1999, In: Endocrinology. 140, 6, p. 2632-2636 5 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  31 Citations (Scopus)

• Activation of cell migration via morphological changes in focal adhesions depends on shear stress in MYCN-amplified neuroblastoma cells

  Hiraiwa, T., Yamada, T. G., Miki, N., Funahashi, A. & Hiroi, N., 2019 Mar 1, In: Journal of the Royal Society Interface. 16, 152, 20180934.

  Research output: Contribution to journal › Article › peer-review
  4 Citations (Scopus)

• Activation of Cdh1-dependent APC is required for G₁ cell cycle arrest and DNA damage-induced G₂ checkpoint in vertebrate cells

  Sudo, T., Ota, Y., Kotani, S., Nakao, M., Takami, Y., Takeda, S. & Saya, H., 2001 Nov 15, In: EMBO Journal. 20, 22, p. 6499-6508 10 p.

  Research output: Contribution to journal › Article › peer-review
  125 Citations (Scopus)

• Activation of CCAAT/enhancer-binding protein α or PU.1 in hematopoietic stem cells leads to their reduced self-renewal and proliferation

  Fukuchi, Y., Ito, M., Shibata, F., Kitamura, T. & Nakajima, H., 2008 Dec, In: Stem Cells. 26, 12, p. 3172-3181 10 p.

  Research output: Contribution to journal › Article › peer-review
  18 Citations (Scopus)

• Activation of caspase-12 by endoplasmic reticulum stress induced by transient middle cerebral artery occlusion in mice

  Shibata, M., Hattori, H., Sasaki, T., Gotoh, J., Hamada, J. & Fukuuchi, Y., 2003 May 8, In: Neuroscience. 118, 2, p. 491-499 9 p.

  Research output: Contribution to journal › Article › peer-review
  121 Citations (Scopus)

• Activation of cardiac Cdk9 represses PGC-1 and confers a predisposition to heart failure

  Sano, M., Wang, S. C., Shirai, M., Scaglia, F., Xie, M., Sakai, S., Tanaka, T., Kulkarni, P. A., Barger, P. M., Youker, K. A., Taffet, G. E., Hamamori, Y., Michael, L. H., Craigen, W. J. & Schneider, M. D., 2004 Sep 1, In: EMBO Journal. 23, 17, p. 3559-3569 11 p.

  Research output: Contribution to journal › Article › peer-review
  138 Citations (Scopus)

• Activation of carboxyl groups by diphenyl 2-oxo-3-oxazolinylphosphonate. Facile preparation of versatile reagents, 3-acyl-2-oxazolones

  Kunieda, T., Higuchi, T., Abe, Y. & Hirobe, M., 1983, In: Tetrahedron. 39, 20, p. 3253-3260 8 p.

  Research output: Contribution to journal › Article › peer-review
  38 Citations (Scopus)

• Activation of Boron-Doped Diamond Electrodes for Electrochemical CO₂Reduction in a Halogen-free Electrolyte

  Otake, A., Du, J. & Einaga, Y., 2022 Nov 7, In: ACS Sustainable Chemistry and Engineering. 10, 44, p. 14445-14450 6 p.

  Research output: Contribution to journal › Article › peer-review

• Activation of aryl hydrocarbon receptor promotes invasion of clear cell renal cell carcinoma and is associated with poor prognosis and cigarette smoke

  Ishida, M., Mikami, S., Shinojima, T., Kosaka, T., Mizuno, R., Kikuchi, E., Miyajima, A., Okada, Y. & Oya, M., 2015 Jul 15, In: International Journal of Cancer. 137, 2, p. 299-310 12 p.

  Research output: Contribution to journal › Article › peer-review
  27 Citations (Scopus)

• Activation of apoptosis by caspase-3-dependent specific RelB cleavage in anticancer agent-treated cancer cells: Involvement of positive feedback mechanism

  Kuboki, M., Ito, A., Simizu, S. & Umezawa, K., 2015 Jan 16, In: Biochemical and Biophysical Research Communications. 456, 3, p. 810-814 5 p.

  Research output: Contribution to journal › Article › peer-review
  7 Citations (Scopus)

• Activation of aniline by extracts from plants and induction of chromosomal damages in Chinese hamster ovary cells

  Kanaya, N., 1996, In: Genes and Genetic Systems. 71, 5, p. 319-322 4 p.

  Research output: Contribution to journal › Article › peer-review

• Activation of a neutrophil-derived inflammatory response in the airways during cardiopulmonary bypass

  Kotani, T., Kotake, Y., Morisaki, H., Takeda, J., Shimizu, H., Ueda, T. & Ishizaka, A., 2006 Dec, In: Anesthesia and analgesia. 103, 6, p. 1394-1399 6 p.

  Research output: Contribution to journal › Article › peer-review
  12 Citations (Scopus)

• ACTIVATION OF ALVEOLAR MACROPHAGES WITH POLYCARBOXYLIC ACID POLYMERS AS IMMUNOMODULATORS.

  Ottenbrite, R. M., Sunamoto, J., Sato, T. & Oka, M., 1985 Apr 1, In: American Chemical Society, Polymer Preprints, Division of Polymer Chemistry. 26, 1, p. 212-213 2 p.

  Research output: Contribution to journal › Conference article › peer-review
  4 Citations (Scopus)

• Activation of a diluted E. coli cell-free transcription-translation system within liposomes by hypertonic concentration

  Matsui, Y., Akui, T., Doi, N. & Fujiwara, K., 2021 Dec 17, In: STAR Protocols. 2, 4, 101003.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  1 Citation (Scopus)