Find Research outputs

Search results

• Article

  Targeted next-generation sequencing in the diagnosis of neurodevelopmental disorders

  Okamoto, N., Miya, F., Tsunoda, T., Kato, M., Saitoh, S., Yamasaki, M., Shimizu, A., Torii, C., Kanemura, Y. & Kosaki, K., 2015 Sep 1, In: Clinical Genetics. 88, 3, p. 288-292 5 p.

  Research output: Contribution to journal › Article › peer-review
  27 Citations (Scopus)

• Targeted next-generation sequencing of cancer-related genes in thyroid carcinoma: A single institution's experience

  Bandoh, N., Akahane, T., Goto, T., Kono, M., Ichikawa, H., Sawada, T., Yamaguchi, T., Nakano, H., Kawase, Y., Kato, Y., Kamada, H., Harabuchi, Y., Shimizu, K. & Nishihara, H., 2018 Dec, In: Oncology Letters. 16, 6, p. 7278-7286 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  17 Citations (Scopus)

• Targeted proteomics reveals promising biomarkers of disease activity and organ involvement in antineutrophil cytoplasmic antibody-associated vasculitis

  and for the Research Committee of Intractable Vasculitis Syndrome and the Research Committee of Intractable Renal Disease of the Ministry of Health, Labour and Welfare of Japan, 2017 Sep 29, In: Arthritis Research and Therapy. 19, 1, 218.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  35 Citations (Scopus)

• Targeted reversion of induced pluripotent stem cells from patients with human cleidocranial dysplasia improves bone regeneration in a rat calvarial bone defect model

  Saito, A., Ooki, A., Nakamura, T., Onodera, S., Hayashi, K., Hasegawa, D., Okudaira, T., Watanabe, K., Kato, H., Onda, T., Watanabe, A., Kosaki, K., Nishimura, K., Ohtaka, M., Nakanishi, M., Sakamoto, T., Yamaguchi, A., Sueishi, K. & Azuma, T., 2018 Jan 22, In: Stem Cell Research and Therapy. 9, 1, 12.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  21 Citations (Scopus)

• Targeted suppression of human IBD-associated gut microbiota commensals by phage consortia for treatment of intestinal inflammation

  Federici, S., Kredo-Russo, S., Valdés-Mas, R., Kviatcovsky, D., Weinstock, E., Matiuhin, Y., Silberberg, Y., Atarashi, K., Furuichi, M., Oka, A., Liu, B., Fibelman, M., Weiner, I. N., Khabra, E., Cullin, N., Ben-Yishai, N., Inbar, D., Ben-David, H., Nicenboim, J., Kowalsman, N., & 33 othersLieb, W., Kario, E., Cohen, T., Geffen, Y. F., Zelcbuch, L., Cohen, A., Rappo, U., Gahali-Sass, I., Golembo, M., Lev, V., Dori-Bachash, M., Shapiro, H., Moresi, C., Cuevas-Sierra, A., Mohapatra, G., Kern, L., Zheng, D., Nobs, S. P., Suez, J., Stettner, N., Harmelin, A., Zak, N., Puttagunta, S., Bassan, M., Honda, K., Sokol, H., Bang, C., Franke, A., Schramm, C., Maharshak, N., Sartor, R. B., Sorek, R. & Elinav, E., 2022 Aug 4, In: Cell. 185, 16, p. 2879-2898.e24

  Research output: Contribution to journal › Article › peer-review
  23 Citations (Scopus)

• Targeted Therapy-induced Facial Skin Toxicities: Impact on Quality of Life in Cancer Patients

  Yagasaki, K., Komatsu, H., Soejima, K., Naoki, K., Kawada, I., Yasuda, H. & Hamamoto, Y., 2018 Apr 1, In: Asia-Pacific Journal of Oncology Nursing. 5, 2, p. 172-177 6 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  6 Citations (Scopus)

• Target identification of bioactive compounds

  Tashiro, E. & Imoto, M., 2012 Mar 15, In: Bioorganic and Medicinal Chemistry. 20, 6, p. 1910-1921 12 p.

  Research output: Contribution to journal › Article › peer-review
  25 Citations (Scopus)

• Target-induced conformational adaptation of calmodulin revealed by the crystal structure of a complex with nematode Ca²⁺/calmodulin-dependent kinase kinase peptide

  Kurokawa, H., Osawa, M., Kurihara, H., Katayama, N., Tokumitsu, H., Swindells, M. B., Kainosho, M. & Ikura, M., 2001 Sep 7, In: Journal of Molecular Biology. 312, 1, p. 59-68 10 p.

  Research output: Contribution to journal › Article › peer-review
  94 Citations (Scopus)

• Targeting activated lymphocytes with an entirely human immunotoxin analogue: Human pancreatic RNase1-human IL-12 fusion

  Psarras, K., Ueda, M., Tanabe, M., Kitajima, M., Aiso, S., Komatsu, S. & Seno, M., 2000 Jun, In: Cytokine. 12, 6, p. 786-790 5 p.

  Research output: Contribution to journal › Article › peer-review
  29 Citations (Scopus)

• Targeting ALCAM in the cryo-treated tumour microenvironment successfully induces systemic anti-tumour immunity

  Kudo-Saito, C., Fuwa, T. & Kawakami, Y., 2016 Jul 1, In: European Journal of Cancer. 62, p. 54-61 8 p.

  Research output: Contribution to journal › Article › peer-review
  10 Citations (Scopus)

• Targeting amino acid metabolic reprogramming via l-type amino acid transporter 1 (Lat1) for endocrine-resistant breast cancer

  Shindo, H., Harada-Shoji, N., Ebata, A., Sato, M., Soga, T., Miyashita, M., Tada, H., Kawai, M., Kosaka, S., Onuki, K., Usami, S., Furumoto, S., Hayashi, S., Abe, T., Suzuki, T., Ishida, T. & Sasano, H., 2021 Sep 1, In: Cancers. 13, 17, 4375.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  3 Citations (Scopus)

• Targeting and quality of nursing home care. A five-nation study

  Carpenter, G. I., Hirdes, J. P., Ribbe, M. W., Ikegami, N., Challis, D., Steel, K., Bernabei, R. & Fries, B., 1999 Apr, In: Aging Clinical and Experimental Research. 11, 2, p. 83-89 7 p.

  Research output: Contribution to journal › Article › peer-review
  22 Citations (Scopus)

• Targeting AURKA in treatment of peritoneal tumor dissemination in gastrointestinal cancer

  Ozawa, H., Imazeki, H., Ogiwara, Y., Kawakubo, H., Fukuda, K., Kitagawa, Y. & Kudo-Saito, C., 2022 Feb, In: Translational Oncology. 16, 101307.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  2 Citations (Scopus)

• Targeting Aurora B to the Equatorial Cortex by MKlp2 Is Required for Cytokinesis

  Kitagawa, M., Fung, S. Y. S., Onishi, N., Saya, H. & Lee, S. H., 2013 Jun 4, In: PloS one. 8, 6, e64826.

  Research output: Contribution to journal › Article › peer-review
  45 Citations (Scopus)

• Targeting brain regions of interest in functional near-infrared spectroscopy—Scalp-cortex correlation using subject-specific light propagation models

  Cai, L., Nitta, T., Yokota, S., Obata, T., Okada, E. & Kawaguchi, H., 2021 May, In: Human Brain Mapping. 42, 7, p. 1969-1986 18 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  2 Citations (Scopus)

• Targeting cancer chemotherapy using a monoclonal antibody (NCC‐LU‐243) conjugated with mitomycin C

  Kubota, T., Yamamoto, T., Takahara, T., Furukawa, T., Ishibiki, K., Kitajima, M., Shida, Y. & Nakatsubo, H., 1992 Oct, In: Journal of Surgical Oncology. 51, 2, p. 75-80 6 p.

  Research output: Contribution to journal › Article › peer-review
  8 Citations (Scopus)

• Targeting cancer therapy in mice by use of newly developed immunoliposomes bearing adriamycin

  Hirota, M., Fukushima, K., Hiratani, K., Kadota, J., Kawano, K., Oka, M., Tomonaga, A., Hara, K., Sato, T. & Sunamoto, J., 1988, In: Journal of Liposome Research. 1, 1, p. 15-33 19 p.

  Research output: Contribution to journal › Article › peer-review
  10 Citations (Scopus)

• Targeting Cellular Calcium Homeostasis to Prevent Cytokine-Mediated Beta Cell Death

  Clark, A. L., Kanekura, K., Lavagnino, Z., Spears, L. D., Abreu, D., Mahadevan, J., Yagi, T., Semenkovich, C. F., Piston, D. W. & Urano, F., 2017 Dec 1, In: Scientific reports. 7, 1, 5611.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  21 Citations (Scopus)

• Targeting chemotherapy of brain tumor using liposome-encapsulated cisplatin—Part 1. Substances associated with liposomes to target brain tumor

  Shibata, S., Jinnouchi, T., Ochi, A., Mori, K., Sato, T. & Sunamoto, J., 1990, In: Drug Delivery System. 5, 2, p. 83-87 5 p.

  Research output: Contribution to journal › Article › peer-review

• Targeting colorectal cancer via its microenvironment by inhibiting IGF-1 receptor-insulin receptor substrate and STAT3 signaling

  Sanchez-Lopez, E., Flashner-Abramson, E., Shalapour, S., Zhong, Z., Taniguchi, K., Levitzki, A. & Karin, M., 2016 May 19, In: Oncogene. 35, 20, p. 2634-2644 11 p.

  Research output: Contribution to journal › Article › peer-review
  97 Citations (Scopus)

• Targeting fibroblast growth factor receptor 3 enhances radiosensitivity in human squamous cancer cells

  Uzawa, K., Ishigami, T., Fushimi, K., Kawata, T., Shinozuka, K., Kasamatsu, A., Sakamoto, Y., Ogawara, K., Shiiba, M., Bukawa, H., Ito, H. & Tanzawa, H., 2011 Oct 27, In: Oncogene. 30, 43, p. 4447-4452 6 p.

  Research output: Contribution to journal › Article › peer-review
  21 Citations (Scopus)

• Targeting FSTL1 prevents tumor bone metastasis and consequent immune dysfunction

  Kudo-Saito, C., Fuwa, T., Murakami, K. & Kawakami, Y., 2013 Oct 15, In: Cancer Research. 73, 20, p. 6185-6193 9 p.

  Research output: Contribution to journal › Article › peer-review
  51 Citations (Scopus)

• Targeting inducible costimulator expressed on CXCR5⁺PD-1⁺ T_H cells suppresses the progression of pemphigus vulgaris

  Kim, A. R., Han, D., Choi, J. Y., Seok, J., Kim, S. E., Seo, S. H., Takahashi, H., Amagai, M., Park, S. H., Kim, S. C., Shin, E. C. & Kim, J. H., 2020 Nov, In: Journal of Allergy and Clinical Immunology. 146, 5, p. 1070-1079.e8

  Research output: Contribution to journal › Article › peer-review

  Open Access
  20 Citations (Scopus)

• Targeting MUC1-C inhibits TWIst1 signaling in triple-negative breast cancer

  Hata, T., Rajabi, H., Yamamoto, M., Jin, C., Ahmad, R., Zhang, Y., Kui, L., Li, W., Yasumizu, Y., Hong, D., Miyo, M., Hiraki, M., Maeda, T., Suzuki, Y., Takahashi, H., Samur, M. & Kufe, D., 2019, In: Molecular cancer therapeutics. 18, 10, p. 1744-1754 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  34 Citations (Scopus)

• Targeting NF-κB and induction of apoptosis by novel NF-κB inhibitor dehydroxymethylepoxyquinomicin (DHMEQ) in Burkitt lymphoma cells

  Kimura, N., Miyakawa, Y., Kohmura, K., Umezawa, K., Ikeda, Y. & Kizaki, M., 2007 Nov 1, In: Leukemia Research. 31, 11, p. 1529-1535 7 p.

  Research output: Contribution to journal › Article › peer-review
  14 Citations (Scopus)

• Targeting of cancer stem cells by differentiation therapy

  Arima, Y., Nobusue, H. & Saya, H., 2020 Aug 1, In: Cancer science. 111, 8, p. 2689-2695 7 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  19 Citations (Scopus)

• Targeting of liposomes carrying recombinant fragments of platelet membrane glycoprotein Ibα to immobilized von Willebrand factor under flow conditions

  Nishiya, T., Murata, M., Handa, M. & Ikeda, Y., 2000 Apr 21, In: Biochemical and Biophysical Research Communications. 270, 3, p. 755-760 6 p.

  Research output: Contribution to journal › Article › peer-review
  27 Citations (Scopus)

• Targeting oxygen-sensing prolyl hydroxylase for metformin-associated lactic acidosis treatment

  Oyaizu-Toramaru, T., Suhara, T., Hayakawa, N., Nakamura, T., Kubo, A., Minamishima, S., Yamaguchi, K., Hishiki, T., Morisaki, H., Suematsu, M. & Minamishima, Y. A., 2017 Aug 1, In: Molecular and cellular biology. 37, 16, e00248-17.

  Research output: Contribution to journal › Article › peer-review
  8 Citations (Scopus)

• Targeting Prolyl-tRNA Synthetase to Accelerate Drug Discovery against Malaria, Leishmaniasis, Toxoplasmosis, Cryptosporidiosis, and Coccidiosis

  Jain, V., Yogavel, M., Kikuchi, H., Oshima, Y., Hariguchi, N., Matsumoto, M., Goel, P., Touquet, B., Jumani, R. S., Tacchini-Cottier, F., Harlos, K., Huston, C. D., Hakimi, M. A. & Sharma, A., 2017 Oct 3, In: Structure. 25, 10, p. 1495-1505.e6

  Research output: Contribution to journal › Article › peer-review

  Open Access
  46 Citations (Scopus)

• Targeting the ERK signaling pathway as a potential treatment for insulin resistance and type 2 diabetes

  Ozaki, K. I., Awazu, M., Tamiya, M., Iwasaki, Y., Harada, A., Kugisaki, S., Tanimura, S. & Kohno, M., 2016 Apr 15, In: American Journal of Physiology - Endocrinology and Metabolism. 310, 8, p. E643-E651

  Research output: Contribution to journal › Article › peer-review

  Open Access
  91 Citations (Scopus)

• Targeting the HGF/MET Axis counters primary resistance to KIT inhibition in KIT-mutant melanoma

  Oba, J., Kim, S. H., Wang, W. L., Macedo, M. P., Carapeto, F., McKean, M. A., Van Arnam, J., Eterovic, A. K., Sen, S., Kale, C. R., Yu, X., Haymaker, C. L., Routbort, M., Haydu, L. E., Bernatchez, C., Lazar, A. J., Grimm, E. A., Hong, D. S. & Woodman, S. E., 2018, In: JCO Precision Oncology. 2, p. 1-8 8 p.

  Research output: Contribution to journal › Article › peer-review
  12 Citations (Scopus)

• Targeting the Janus kinases in rheumatoid arthritis: Focus on tofacitinib

  Yamaoka, K. & Tanaka, Y., 2014 Jan, In: Expert Opinion on Pharmacotherapy. 15, 1, p. 103-113 11 p.

  Research output: Contribution to journal › Article › peer-review
  17 Citations (Scopus)

• Targeting therapy using monoclonal antibody directed against growth factor receptors

  Jinno, H., Ueda, M., Enomoto, K., Ikeda, T. & Kitajima, M., 1993 Sep, In: Human cell : official journal of Human Cell Research Society. 6, 3, p. 188-193 6 p.

  Research output: Contribution to journal › Article › peer-review
  1 Citation (Scopus)

• Target protein-oriented isolation of Hes1 dimer inhibitors using protein based methods

  Arai, M. A., Morita, K., Kawano, H., Makita, Y., Hashimoto, M., Suganami, A., Tamura, Y., Sadhu, S. K., Ahmed, F. & Ishibashi, M., 2020 Dec 1, In: Scientific reports. 10, 1, 1381.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  6 Citations (Scopus)

• Target-selective degradation of oligosaccharides by a light-activated small-molecule-lectin hybrid

  Ishii, M., Matsumura, S. & Toshima, K., 2007 Nov 21, In: Angewandte Chemie - International Edition. 46, 44, p. 8396-8399 4 p.

  Research output: Contribution to journal › Article › peer-review
  24 Citations (Scopus)

• Target-selective degradation of proteins by a light-activated 2-phenylquinoline-estradiol hybrid

  Suzuki, A., Tsumura, K., Tsuzuki, T., Matsumura, S. & Toshima, K., 2007 Jan 1, In: Chemical Communications. 41, p. 4260-4262 3 p.

  Research output: Contribution to journal › Article › peer-review
  18 Citations (Scopus)

• Target-selective degradation of proteins by porphyrins upon visible photo-irradiation

  Tanimoto, S., Matsumura, S. & Toshima, K., 2008, In: Chemical Communications. 31, p. 3678-3680 3 p.

  Research output: Contribution to journal › Article › peer-review
  26 Citations (Scopus)

• Target-Selective Fluorescence Imaging and Photocytotoxicity against H₂O₂ High-Expressing Cancer Cells Using a Photoactivatable Theranostic Agent

  Takagi, R., Takeda, A., Takahashi, D. & Toshima, K., 2017 Oct 18, In: Chemistry - An Asian Journal. 12, 20, p. 2656-2659 4 p.

  Research output: Contribution to journal › Article › peer-review
  11 Citations (Scopus)

• Target-selective photo-degradation of AFP-L3 and selective photo-cytotoxicity against HuH-7 hepatocarcinoma cells using an anthraquinone-PhoSL hybrid

  Okuyama, M., Ueno, H., Kobayashi, Y., Kawagishi, H., Takahashi, D. & Toshima, K., 2016, In: Chemical Communications. 52, 10, p. 2169-2172 4 p.

  Research output: Contribution to journal › Article › peer-review
  10 Citations (Scopus)

• Target-selective photo-degradation of a sialyl Lewis a (sLe^a) conjugate and photo-cytotoxicity against sLe^a positive cancer cells using an anthraquinone-antibody hybrid

  Takahashi, D., Nagao, T., Sotokawa, S. & Toshima, K., 2016, In: MedChemComm. 7, 6, p. 1224-1228 5 p.

  Research output: Contribution to journal › Article › peer-review
  2 Citations (Scopus)

• Target-selective photodegradation of HIV-1 protease and inhibition of HIV-1 replication in living cells by designed fullerene-sugar hybrids

  Tanimoto, S., Sakai, S., Kudo, E., Okada, S., Matsumura, S., Takahashi, D. & Toshima, K., 2012 May, In: Chemistry - An Asian Journal. 7, 5, p. 911-914 4 p.

  Research output: Contribution to journal › Article › peer-review
  24 Citations (Scopus)

• Target-selective photo-degradation of HIV-1 protease by a fullerene-sugar hybrid

  Tanimoto, S., Sakai, S., Matsumura, S., Takahashi, D. & Toshima, K., 2008, In: Chemical Communications. 44, p. 5767-5769 3 p.

  Research output: Contribution to journal › Article › peer-review
  57 Citations (Scopus)

• Target-selective photodegradation of oligosaccharides by a fullerene-boronic acid hybrid upon visible light irradiation

  Takahashi, D., Hirono, S. & Toshima, K., 2011 Nov 14, In: Chemical Communications. 47, 42, p. 11712-11714 3 p.

  Research output: Contribution to journal › Article › peer-review
  12 Citations (Scopus)

• Target-selective photo-degradation of verotoxin-1 and reduction of its cytotoxicity to Vero cells using porphyrin–globotriose hybrids

  Okochi, A., Tanimoto, S., Takahashi, D. & Toshima, K., 2013 Jun 11, In: Chemical Communications. 49, 54, p. 6027-6029 3 p.

  Research output: Contribution to journal › Article › peer-review
  8 Citations (Scopus)

• Target setting for lower limb joint surgery using the Timed Up and Go test in patients with rheumatoid arthritis: A prospective cohort study

  Kojima, T., Ishikawa, H., Tanaka, S., Haga, N., Nishida, K., Yukioka, M., Hashimoto, J., Miyahara, H., Niki, Y., Kimura, T., Oda, H., Asai, S., Funahashi, K., Kojima, M. & Ishiguro, N., 2018 Oct, In: International Journal of Rheumatic Diseases. 21, 10, p. 1801-1808 8 p.

  Research output: Contribution to journal › Article › peer-review
  4 Citations (Scopus)

• Targets of treatment in the acute phase of cerebral infarction

  Tanaka, K., Fukuuchi, Y., Nogawa, S., Ito, D., Suzuki, S., Dembo, T. & Kosakai, A., 2001 Dec 1, In: Clinical Neurology. 41, 12, p. 1052-1054 3 p.

  Research output: Contribution to journal › Article › peer-review
  4 Citations (Scopus)

• TARZAN: An FMIPv6 implementation using link layer abstractions

  Mitsuya, K., Teraoka, F., Murai, J. & Mitani, K., 2007 Dec 1, In: Computer Software. 24, 4, p. 123-138 16 p.

  Research output: Contribution to journal › Article › peer-review

• TAS6417/CLN-081 is a pan-mutation-selective EGFR tyrosine kinase inhibitor with a broad spectrum of preclinical activity against clinically relevant EGFR mutations

  Udagawa, H., Hasako, S., Ohashi, A., Fujioka, R., Hakozaki, Y., Shibuya, M., Abe, N., Komori, T., Haruma, T., Terasaka, M., Fujita, R., Hashimoto, A., Funabashi, K., Yasuda, H., Miyadera, K., Goto, K., Costa, D. B. & Kobayashi, S. S., 2019, In: Molecular Cancer Research. 17, 11, p. 2233-2243 11 p.

  Research output: Contribution to journal › Article › peer-review
  32 Citations (Scopus)

• Task description and control for redundant system by oblique coordinate control

  Sakaino, S., Sato, T. & Ohnishi, K., 2010 Sep 28, In: ieej transactions on industry applications. 130, 8, p. 1015-1021+9

  Research output: Contribution to journal › Article › peer-review
  6 Citations (Scopus)

• Task preservation of multi-degree-of-freedom motion using interaction mode control

  Katsura, S. & Ohishi, K., 2008 Jan 1, In: EPE Journal (European Power Electronics and Drives Journal). 18, 1, p. 16-24 9 p.

  Research output: Contribution to journal › Article › peer-review