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  Targeted deletion or pharmacological inhibition of MMP-2 prevents cardiac rupture after myocardial infarction in mice

  Matsumura, S. I., Iwanaga, S., Mochizuki, S., Okamoto, H., Ogawa, S. & Okada, Y., 2005 Mar, In: Journal of Clinical Investigation. 115, 3, p. 599-609 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  268 Citations (Scopus)

• Targeted Discovery of Amantamide B, an Ion Channel Modulating Nonapeptide from a South China Sea Oscillatoria Cyanobacterium

  Li, T., Xi, C., Yu, Y., Wang, N., Wang, X., Iwasaki, A., Fang, F., Ding, L., Li, S., Zhang, W., Yuan, Y., Wang, T., Yan, X., He, S., Cao, Z. & Naman, C. B., 2022 Mar 25, In: Journal of Natural Products. 85, 3, p. 493-500 8 p.

  Research output: Contribution to journal › Article › peer-review

• Targeted disruption of NMDA receptor 1 gene abolishes NMDA response and results in neonatal death

  Forrest, D., Yuzaki, M., Soares, H. D., Ng, L., Luk, D. C., Sheng, M., Stewart, C. L., Morgan, J. I., Connor, J. A. & Curran, T., 1994 Aug, In: Neuron. 13, 2, p. 325-338 14 p.

  Research output: Contribution to journal › Article › peer-review
  402 Citations (Scopus)

• Targeted disruption of Skp2 results in accumulation of cyclin E and p27 (Kip1), polyploidy and centrosome overduplication

  Nakayama, K., Nagahama, H., Minamishima, Y. A., Matsumoto, M., Nakamichi, I., Kitagawa, K., Shirane, M., Tsunematsu, R., Tsukiyama, T., Ishida, N., Kitagawa, M., Nakayama, K. I. & Hatakeyama, S., 2000 May 2, In: EMBO Journal. 19, 9, p. 2069-2081 13 p.

  Research output: Contribution to journal › Article › peer-review
  626 Citations (Scopus)

• Targeted DNA transfection into the mouse central nervous system using laser-induced stress waves

  Satoh, Y., Kanda, Y., Terakawa, M., Obara, M., Mizuno, K., Watanabe, Y., Endo, S., Ooigawa, H., Nawashiro, H., Sato, S. & Takishima, K., 2005 Nov, In: Journal of Biomedical Optics. 10, 6, 060501.

  Research output: Contribution to journal › Article › peer-review
  45 Citations (Scopus)

• Targeted embolisation for coexisting conus medullaris arteriovenous malformation and cauda equina arteriovenous fistulas with a varix on a shared drainer†

  Yoshida, K., Niimi, Y., Kamamoto, D., Fukumura, M., Imai, R., Nagoshi, N. & Akiyama, T., 2020, (Accepted/In press) In: British Journal of Neurosurgery.

  Research output: Contribution to journal › Article › peer-review

• Targeted expression of anti-apoptotic protein p35 in oligodendrocytes reduces delayed demyelination and functional impairment after spinal cord injury

  Tamura, M., Nakamura, M., Ogawa, Y., Toyama, Y., Miura, M. & Okano, H., 2005 Sep 1, In: Glia. 51, 4, p. 312-321 10 p.

  Research output: Contribution to journal › Article › peer-review
  11 Citations (Scopus)

• Targeted expression of baculovirus p35 caspase inhibitor in oligodendrocytes protects mice against autoimmune-mediated demyelination

  Hisahara, S., Araki, T., Sugiyama, F., Yagami, K. I., Suzuki, M., Abe, K., Yamamura, K. I., Miyazaki, J. I., Momoi, T., Saruta, T., Bernard, C. C. A., Okano, H. & Miura, M., 2000 Feb 1, In: EMBO Journal. 19, 3, p. 341-348 8 p.

  Research output: Contribution to journal › Article › peer-review
  96 Citations (Scopus)

• Targeted expression of tgfbip peptides in mouse and human tissue by maldi-mass spectrometry imaging

  Anandalakshmi, V., Hochart, G., Bonnel, D., Stauber, J., Shimmura, S., Lakshminarayanan, R., Pervushin, K. & Mehta, J. S., 2021 Jul, In: Separations. 8, 7, 97.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Targeted gene correction of RUNX1 in induced pluripotent stem cells derived from familial platelet disorder with propensity to myeloid malignancy restores normal megakaryopoiesis

  Iizuka, H., Kagoya, Y., Kataoka, K., Yoshimi, A., Miyauchi, M., Taoka, K., Kumano, K., Yamamoto, T., Hotta, A., Arai, S. & Kurokawa, M., 2015 Oct 1, In: Experimental Hematology. 43, 10, p. 849-857 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  32 Citations (Scopus)

• Targeted gene delivery in the cricket brain, using in vivo electroporation

  Matsumoto, C. S., Shidara, H., Matsuda, K., Nakamura, T., Mito, T., Matsumoto, Y., Oka, K. & Ogawa, H., 2013 Dec, In: Journal of Insect Physiology. 59, 12, p. 1235-1241 7 p.

  Research output: Contribution to journal › Article › peer-review
  5 Citations (Scopus)

• Targeted gene delivery using humanized single-chain antibody with negatively charged oligopeptide tail

  Suzuki, M., Takayanagi, A. & Shimizu, N., 2004 May, In: Cancer science. 95, 5, p. 424-429 6 p.

  Research output: Contribution to journal › Article › peer-review
  11 Citations (Scopus)

• Targeted gene modification in mouse ES cells using integrase-defective lentiviral vectors

  Okada, Y., Ueshin, Y., Hasuwa, H., Takumi, K., Okabe, M. & Ikawa, M., 2009, In: Genesis. 47, 4, p. 217-223 7 p.

  Research output: Contribution to journal › Article › peer-review
  26 Citations (Scopus)

• Targeted inhibition of IL-10-secreting CD25^- Treg via p38 MAPK suppression in cancer immunotherapy

  Ohkusu-Tsukada, K., Toda, M., Udono, H., Kawakami, Y. & Takahashi, K., 2010 Apr, In: European Journal of Immunology. 40, 4, p. 1011-1021 11 p.

  Research output: Contribution to journal › Article › peer-review
  30 Citations (Scopus)

• Targeted introduction of V642I mutation in amyloid precursor protein gene causes functional abnormality resembling early stage of Alzheimer's disease in aged mice

  Kawasumi, M., Chiba, T., Yamada, M., Miyamae-Kaneko, M., Matsuoka, M., Nakahara, J., Tomita, T., Iwatsubo, T., Kato, S., Aiso, S., Nishimoto, I. & Kouyama, K., 2004 May 1, In: European Journal of Neuroscience. 19, 10, p. 2826-2838 13 p.

  Research output: Contribution to journal › Article › peer-review
  46 Citations (Scopus)

• Targeted in vivo delivery of therapeutic gene into experimental squamous cell carcinomas using anti-epidermal growth factor receptor antibody: Immunogene approach

  Chen, J., Gamou, S., Takayanagi, A., Ohtake, Y., Ohtsubo, M. & Shimizu, N., 1998 Dec 10, In: Human Gene Therapy. 9, 18, p. 2673-2681 9 p.

  Research output: Contribution to journal › Article › peer-review
  20 Citations (Scopus)

• Targeted Isolation of a Designated Region of the Bacillus subtilis Genome by Recombinational Transfer

  Tomita, S., Tsuge, K., Kikuchi, Y. & Itaya, M., 2004 Apr, In: Applied and Environmental Microbiology. 70, 4, p. 2508-2513 6 p.

  Research output: Contribution to journal › Article › peer-review
  16 Citations (Scopus)

• Targeted lymph node assessment in gastrointestinal neoplasms

  O'Connor, V., Kitagawa, Y., Stojadinovic, A. & Bilchik, A. J., 2014 Jan, In: Current Problems in Surgery. 51, 1, p. 9-37 29 p.

  Research output: Contribution to journal › Article › peer-review

• Targeted next-generation sequencing in the diagnosis of neurodevelopmental disorders

  Okamoto, N., Miya, F., Tsunoda, T., Kato, M., Saitoh, S., Yamasaki, M., Shimizu, A., Torii, C., Kanemura, Y. & Kosaki, K., 2015 Sep 1, In: Clinical Genetics. 88, 3, p. 288-292 5 p.

  Research output: Contribution to journal › Article › peer-review
  26 Citations (Scopus)

• Targeted next-generation sequencing of cancer-related genes in thyroid carcinoma: A single institution's experience

  Bandoh, N., Akahane, T., Goto, T., Kono, M., Ichikawa, H., Sawada, T., Yamaguchi, T., Nakano, H., Kawase, Y., Kato, Y., Kamada, H., Harabuchi, Y., Shimizu, K. & Nishihara, H., 2018 Dec, In: Oncology Letters. 16, 6, p. 7278-7286 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  16 Citations (Scopus)

• Targeted proteomics reveals promising biomarkers of disease activity and organ involvement in antineutrophil cytoplasmic antibody-associated vasculitis

  and for the Research Committee of Intractable Vasculitis Syndrome and the Research Committee of Intractable Renal Disease of the Ministry of Health, Labour and Welfare of Japan, 2017 Sep 29, In: Arthritis Research and Therapy. 19, 1, 218.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  32 Citations (Scopus)

• Targeted reversion of induced pluripotent stem cells from patients with human cleidocranial dysplasia improves bone regeneration in a rat calvarial bone defect model

  Saito, A., Ooki, A., Nakamura, T., Onodera, S., Hayashi, K., Hasegawa, D., Okudaira, T., Watanabe, K., Kato, H., Onda, T., Watanabe, A., Kosaki, K., Nishimura, K., Ohtaka, M., Nakanishi, M., Sakamoto, T., Yamaguchi, A., Sueishi, K. & Azuma, T., 2018 Jan 22, In: Stem Cell Research and Therapy. 9, 1, 12.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  19 Citations (Scopus)

• Targeted Therapy-induced Facial Skin Toxicities: Impact on Quality of Life in Cancer Patients

  Yagasaki, K., Komatsu, H., Soejima, K., Naoki, K., Kawada, I., Yasuda, H. & Hamamoto, Y., 2018 Apr 1, In: Asia-Pacific Journal of Oncology Nursing. 5, 2, p. 172-177 6 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  4 Citations (Scopus)

• Target identification of bioactive compounds

  Tashiro, E. & Imoto, M., 2012 Mar 15, In: Bioorganic and Medicinal Chemistry. 20, 6, p. 1910-1921 12 p.

  Research output: Contribution to journal › Article › peer-review
  25 Citations (Scopus)

• Target-induced conformational adaptation of calmodulin revealed by the crystal structure of a complex with nematode Ca²⁺/calmodulin-dependent kinase kinase peptide

  Kurokawa, H., Osawa, M., Kurihara, H., Katayama, N., Tokumitsu, H., Swindells, M. B., Kainosho, M. & Ikura, M., 2001 Sep 7, In: Journal of Molecular Biology. 312, 1, p. 59-68 10 p.

  Research output: Contribution to journal › Article › peer-review
  92 Citations (Scopus)

• Targeting activated lymphocytes with an entirely human immunotoxin analogue: Human pancreatic RNase1-human IL-12 fusion

  Psarras, K., Ueda, M., Tanabe, M., Kitajima, M., Aiso, S., Komatsu, S. & Seno, M., 2000 Jun, In: Cytokine. 12, 6, p. 786-790 5 p.

  Research output: Contribution to journal › Article › peer-review
  29 Citations (Scopus)

• Targeting ALCAM in the cryo-treated tumour microenvironment successfully induces systemic anti-tumour immunity

  Kudo-Saito, C., Fuwa, T. & Kawakami, Y., 2016 Jul 1, In: European Journal of Cancer. 62, p. 54-61 8 p.

  Research output: Contribution to journal › Article › peer-review
  10 Citations (Scopus)

• Targeting amino acid metabolic reprogramming via l-type amino acid transporter 1 (Lat1) for endocrine-resistant breast cancer

  Shindo, H., Harada-Shoji, N., Ebata, A., Sato, M., Soga, T., Miyashita, M., Tada, H., Kawai, M., Kosaka, S., Onuki, K., Usami, S., Furumoto, S., Hayashi, S., Abe, T., Suzuki, T., Ishida, T. & Sasano, H., 2021 Sep 1, In: Cancers. 13, 17, 4375.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  2 Citations (Scopus)

• Targeting and quality of nursing home care. A five-nation study

  Carpenter, G. I., Hirdes, J. P., Ribbe, M. W., Ikegami, N., Challis, D., Steel, K., Bernabei, R. & Fries, B., 1999 Apr, In: Aging Clinical and Experimental Research. 11, 2, p. 83-89 7 p.

  Research output: Contribution to journal › Article › peer-review
  22 Citations (Scopus)

• Targeting AURKA in treatment of peritoneal tumor dissemination in gastrointestinal cancer

  Ozawa, H., Imazeki, H., Ogiwara, Y., Kawakubo, H., Fukuda, K., Kitagawa, Y. & Kudo-Saito, C., 2022 Feb, In: Translational Oncology. 16, 101307.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  1 Citation (Scopus)

• Targeting Aurora B to the Equatorial Cortex by MKlp2 Is Required for Cytokinesis

  Kitagawa, M., Fung, S. Y. S., Onishi, N., Saya, H. & Lee, S. H., 2013 Jun 4, In: PloS one. 8, 6, e64826.

  Research output: Contribution to journal › Article › peer-review
  44 Citations (Scopus)

• Targeting brain regions of interest in functional near-infrared spectroscopy—Scalp-cortex correlation using subject-specific light propagation models

  Cai, L., Nitta, T., Yokota, S., Obata, T., Okada, E. & Kawaguchi, H., 2021 May, In: Human Brain Mapping. 42, 7, p. 1969-1986 18 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  2 Citations (Scopus)

• Targeting cancer chemotherapy using a monoclonal antibody (NCC‐LU‐243) conjugated with mitomycin C

  Kubota, T., Yamamoto, T., Takahara, T., Furukawa, T., Ishibiki, K., Kitajima, M., Shida, Y. & Nakatsubo, H., 1992 Oct, In: Journal of Surgical Oncology. 51, 2, p. 75-80 6 p.

  Research output: Contribution to journal › Article › peer-review
  8 Citations (Scopus)

• Targeting cancer therapy in mice by use of newly developed immunoliposomes bearing adriamycin

  Hirota, M., Fukushima, K., Hiratani, K., Kadota, J., Kawano, K., Oka, M., Tomonaga, A., Hara, K., Sato, T. & Sunamoto, J., 1988, In: Journal of Liposome Research. 1, 1, p. 15-33 19 p.

  Research output: Contribution to journal › Article › peer-review
  10 Citations (Scopus)

• Targeting Cellular Calcium Homeostasis to Prevent Cytokine-Mediated Beta Cell Death

  Clark, A. L., Kanekura, K., Lavagnino, Z., Spears, L. D., Abreu, D., Mahadevan, J., Yagi, T., Semenkovich, C. F., Piston, D. W. & Urano, F., 2017 Dec 1, In: Scientific reports. 7, 1, 5611.

  Research output: Contribution to journal › Article › peer-review
  20 Citations (Scopus)

• Targeting chemotherapy of brain tumor using liposome-encapsulated cisplatin—Part 1. Substances associated with liposomes to target brain tumor

  Shibata, S., Jinnouchi, T., Ochi, A., Mori, K., Sato, T. & Sunamoto, J., 1990, In: Drug Delivery System. 5, 2, p. 83-87 5 p.

  Research output: Contribution to journal › Article › peer-review

• Targeting colorectal cancer via its microenvironment by inhibiting IGF-1 receptor-insulin receptor substrate and STAT3 signaling

  Sanchez-Lopez, E., Flashner-Abramson, E., Shalapour, S., Zhong, Z., Taniguchi, K., Levitzki, A. & Karin, M., 2016 May 19, In: Oncogene. 35, 20, p. 2634-2644 11 p.

  Research output: Contribution to journal › Article › peer-review
  90 Citations (Scopus)

• Targeting fibroblast growth factor receptor 3 enhances radiosensitivity in human squamous cancer cells

  Uzawa, K., Ishigami, T., Fushimi, K., Kawata, T., Shinozuka, K., Kasamatsu, A., Sakamoto, Y., Ogawara, K., Shiiba, M., Bukawa, H., Ito, H. & Tanzawa, H., 2011 Oct 27, In: Oncogene. 30, 43, p. 4447-4452 6 p.

  Research output: Contribution to journal › Article › peer-review
  19 Citations (Scopus)

• Targeting FSTL1 prevents tumor bone metastasis and consequent immune dysfunction

  Kudo-Saito, C., Fuwa, T., Murakami, K. & Kawakami, Y., 2013 Oct 15, In: Cancer Research. 73, 20, p. 6185-6193 9 p.

  Research output: Contribution to journal › Article › peer-review
  49 Citations (Scopus)

• Targeting inducible costimulator expressed on CXCR5⁺PD-1⁺ T_H cells suppresses the progression of pemphigus vulgaris

  Kim, A. R., Han, D., Choi, J. Y., Seok, J., Kim, S. E., Seo, S. H., Takahashi, H., Amagai, M., Park, S. H., Kim, S. C., Shin, E. C. & Kim, J. H., 2020 Nov, In: Journal of Allergy and Clinical Immunology. 146, 5, p. 1070-1079.e8

  Research output: Contribution to journal › Article › peer-review

  Open Access
  18 Citations (Scopus)

• Targeting MUC1-C inhibits TWIst1 signaling in triple-negative breast cancer

  Hata, T., Rajabi, H., Yamamoto, M., Jin, C., Ahmad, R., Zhang, Y., Kui, L., Li, W., Yasumizu, Y., Hong, D., Miyo, M., Hiraki, M., Maeda, T., Suzuki, Y., Takahashi, H., Samur, M. & Kufe, D., 2019, In: Molecular cancer therapeutics. 18, 10, p. 1744-1754 11 p.

  Research output: Contribution to journal › Article › peer-review
  27 Citations (Scopus)

• Targeting NF-κB and induction of apoptosis by novel NF-κB inhibitor dehydroxymethylepoxyquinomicin (DHMEQ) in Burkitt lymphoma cells

  Kimura, N., Miyakawa, Y., Kohmura, K., Umezawa, K., Ikeda, Y. & Kizaki, M., 2007 Nov 1, In: Leukemia Research. 31, 11, p. 1529-1535 7 p.

  Research output: Contribution to journal › Article › peer-review
  14 Citations (Scopus)

• Targeting of cancer stem cells by differentiation therapy

  Arima, Y., Nobusue, H. & Saya, H., 2020 Aug 1, In: Cancer science. 111, 8, p. 2689-2695 7 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  11 Citations (Scopus)

• Targeting of liposomes carrying recombinant fragments of platelet membrane glycoprotein Ibα to immobilized von Willebrand factor under flow conditions

  Nishiya, T., Murata, M., Handa, M. & Ikeda, Y., 2000 Apr 21, In: Biochemical and Biophysical Research Communications. 270, 3, p. 755-760 6 p.

  Research output: Contribution to journal › Article › peer-review
  26 Citations (Scopus)

• Targeting oxygen-sensing prolyl hydroxylase for metformin-associated lactic acidosis treatment

  Oyaizu-Toramaru, T., Suhara, T., Hayakawa, N., Nakamura, T., Kubo, A., Minamishima, S., Yamaguchi, K., Hishiki, T., Morisaki, H., Suematsu, M. & Minamishima, Y. A., 2017 Aug 1, In: Molecular and cellular biology. 37, 16, e00248-17.

  Research output: Contribution to journal › Article › peer-review
  6 Citations (Scopus)

• Targeting Prolyl-tRNA Synthetase to Accelerate Drug Discovery against Malaria, Leishmaniasis, Toxoplasmosis, Cryptosporidiosis, and Coccidiosis

  Jain, V., Yogavel, M., Kikuchi, H., Oshima, Y., Hariguchi, N., Matsumoto, M., Goel, P., Touquet, B., Jumani, R. S., Tacchini-Cottier, F., Harlos, K., Huston, C. D., Hakimi, M. A. & Sharma, A., 2017 Oct 3, In: Structure. 25, 10, p. 1495-1505.e6

  Research output: Contribution to journal › Article › peer-review

  Open Access
  39 Citations (Scopus)

• Targeting the ERK signaling pathway as a potential treatment for insulin resistance and type 2 diabetes

  Ozaki, K. I., Awazu, M., Tamiya, M., Iwasaki, Y., Harada, A., Kugisaki, S., Tanimura, S. & Kohno, M., 2016 Apr 15, In: American Journal of Physiology - Endocrinology and Metabolism. 310, 8, p. E643-E651

  Research output: Contribution to journal › Article › peer-review

  Open Access
  85 Citations (Scopus)

• Targeting the HGF/MET Axis counters primary resistance to KIT inhibition in KIT-mutant melanoma

  Oba, J., Kim, S. H., Wang, W. L., Macedo, M. P., Carapeto, F., McKean, M. A., Van Arnam, J., Eterovic, A. K., Sen, S., Kale, C. R., Yu, X., Haymaker, C. L., Routbort, M., Haydu, L. E., Bernatchez, C., Lazar, A. J., Grimm, E. A., Hong, D. S. & Woodman, S. E., 2018, In: JCO Precision Oncology. 2, p. 1-8 8 p.

  Research output: Contribution to journal › Article › peer-review
  12 Citations (Scopus)

• Targeting the Janus kinases in rheumatoid arthritis: Focus on tofacitinib

  Yamaoka, K. & Tanaka, Y., 2014 Jan, In: Expert Opinion on Pharmacotherapy. 15, 1, p. 103-113 11 p.

  Research output: Contribution to journal › Article › peer-review
  16 Citations (Scopus)

• Targeting therapy using monoclonal antibody directed against growth factor receptors

  Jinno, H., Ueda, M., Enomoto, K., Ikeda, T. & Kitajima, M., 1993 Sep, In: Human cell : official journal of Human Cell Research Society. 6, 3, p. 188-193 6 p.

  Research output: Contribution to journal › Article › peer-review
  1 Citation (Scopus)