A 13-week toxicity study of bismuth in rats by intratracheal intermittent administration

Yuri Sano, Hiroshi Satoh, Momoko Chiba, Atsuko Shinohara, Masahide Okamoto, Koji Serizawa, Hiroshi Nakashima, Kazuyuki Omae

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Although bismuth is widely used as a lead substitute in the industrial field, the toxicity of bismuth by inhalation is little known. We performed a 13-wk intratracheal intermittent bismuth dose toxicity study. Bismuth was administered at dose levels of 0, 0.8, 4, 20 mg/kg to male Crj:CD(SD)IGS rats (SPF) by intratracheal intermittent administration once a week for thirteen weeks to investigate its potential toxic effects; especially for specific adverse effects and changes related to pre-neoplastic lesions. Our results showed foreign body inflammation in the lungs, which was caused by intratracheal administration of bismuth, and physical changes related to pulmonary lesions; however, there were no serious changes in other organs. We concluded that dose-dependent, but not specific adverse effects, were attributable to bismuth inhalation in the rat.

Original languageEnglish
Pages (from-to)242-248
Number of pages7
JournalJournal of Occupational Health
Volume47
Issue number3
DOIs
Publication statusPublished - 2005 May

Fingerprint

Bismuth
Toxicity
Rats
Inhalation
Poisons
Foreign Bodies
Pneumonia
Lung

Keywords

  • Bismuth
  • Intratracheal administration
  • Lead-free solder
  • Rat
  • Subchronic toxicity

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Toxicology

Cite this

Sano, Y., Satoh, H., Chiba, M., Shinohara, A., Okamoto, M., Serizawa, K., ... Omae, K. (2005). A 13-week toxicity study of bismuth in rats by intratracheal intermittent administration. Journal of Occupational Health, 47(3), 242-248. https://doi.org/10.1539/joh.47.242

A 13-week toxicity study of bismuth in rats by intratracheal intermittent administration. / Sano, Yuri; Satoh, Hiroshi; Chiba, Momoko; Shinohara, Atsuko; Okamoto, Masahide; Serizawa, Koji; Nakashima, Hiroshi; Omae, Kazuyuki.

In: Journal of Occupational Health, Vol. 47, No. 3, 05.2005, p. 242-248.

Research output: Contribution to journalArticle

Sano, Y, Satoh, H, Chiba, M, Shinohara, A, Okamoto, M, Serizawa, K, Nakashima, H & Omae, K 2005, 'A 13-week toxicity study of bismuth in rats by intratracheal intermittent administration', Journal of Occupational Health, vol. 47, no. 3, pp. 242-248. https://doi.org/10.1539/joh.47.242
Sano, Yuri ; Satoh, Hiroshi ; Chiba, Momoko ; Shinohara, Atsuko ; Okamoto, Masahide ; Serizawa, Koji ; Nakashima, Hiroshi ; Omae, Kazuyuki. / A 13-week toxicity study of bismuth in rats by intratracheal intermittent administration. In: Journal of Occupational Health. 2005 ; Vol. 47, No. 3. pp. 242-248.
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