A biomimetic hybrid material consisting of CaCO3 mesoporous microspheres and an alternating copolymer for reversed-phase HPLC

Mai Mochida, Yuta Nagai, Hiroto Kumagai, Hiroaki Imai, Daniel Citterio, Yuki Hiruta

Research output: Contribution to journalArticle

Abstract

We developed a biomineral-inspired hybrid material composed of CaCO3 and an organic polymer as a column packing material for HPLC. This material combines a hierarchical mesoporous structure and the functionality of the polymer. The surface of monodispersed mesoporous CaCO3 microspheres was modified with poly(maleic acid-alt-1-octadecene) (PMAcO) comprising hydrophobic alkyl chains and anionic carboxylate groups. PMAcO adsorbed onto the surface of CaCO3 through electrostatic interaction between Ca2+ sites and carboxylate groups, resulting in an octadecene coated microsphere interface. These microspheres were applied as a HPLC column and exhibited reversed-phase retention behavior in the separation of alkylbenzenes. This column showed high alkaline mobile phase resistance compared with the conventionally applied ODS column packing material. Quantitative analysis of the basic antidepressants clomipramine and imipramine spiked into whole blood was achieved with an alkaline mobile phase, demonstrating the potential of the biomineral-inspired material as a HPLC stationary phase for practical applications in routine analyses of basic drugs requiring alkaline mobile phases.

Original languageEnglish
Pages (from-to)4771-4777
Number of pages7
JournalJournal of Materials Chemistry B
Volume7
Issue number31
DOIs
Publication statusPublished - 2019 Jan 1

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Biomimetic materials
Hybrid materials
Microspheres
Copolymers
Clomipramine
Organic polymers
Acids
Imipramine
Coulomb interactions
Antidepressive Agents
Polymers
Blood
Chemical analysis
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Chemistry(all)
  • Biomedical Engineering
  • Materials Science(all)

Cite this

A biomimetic hybrid material consisting of CaCO3 mesoporous microspheres and an alternating copolymer for reversed-phase HPLC. / Mochida, Mai; Nagai, Yuta; Kumagai, Hiroto; Imai, Hiroaki; Citterio, Daniel; Hiruta, Yuki.

In: Journal of Materials Chemistry B, Vol. 7, No. 31, 01.01.2019, p. 4771-4777.

Research output: Contribution to journalArticle

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