A bisindole alkaloid with hedgehog signal inhibitory activity from the myxomycete perichaena chrysosperma

Akinori Shintani; Kazufumi Toume; Yusnita Rifai; Midori A. Arai; Masami Ishibashi

doi:10.1021/np1002687

A bisindole alkaloid with hedgehog signal inhibitory activity from the myxomycete perichaena chrysosperma

Akinori Shintani, Kazufumi Toume, Yusnita Rifai, Midori A. Arai, Masami Ishibashi

Research output: Contribution to journal › Article › peer-review

24 Citations (Scopus)

Abstract

6-Hydroxy-9′-methoxystaurosporinone (1), a new bisindole alkaloid, was isolated from field-collected fruiting bodies of the myxomycete Perichaena chrysosperma, together with two known compounds. The structure of the new alkaloid was elucidated from spectral data, and compound 1 was shown to have hedgehog signal inhibitory activity. A related new alkaloid, 6,9′-dihydroxystaurosporinone (4), was also isolated from Arcyria cinerea.

Original language	English
Pages (from-to)	1711-1713
Number of pages	3
Journal	Journal of Natural Products
Volume	73
Issue number	10
DOIs	https://doi.org/10.1021/np1002687
Publication status	Published - 2010 Oct 22
Externally published	Yes

ASJC Scopus subject areas

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

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10.1021/np1002687

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abstract = "6-Hydroxy-9′-methoxystaurosporinone (1), a new bisindole alkaloid, was isolated from field-collected fruiting bodies of the myxomycete Perichaena chrysosperma, together with two known compounds. The structure of the new alkaloid was elucidated from spectral data, and compound 1 was shown to have hedgehog signal inhibitory activity. A related new alkaloid, 6,9′-dihydroxystaurosporinone (4), was also isolated from Arcyria cinerea.",

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AU - Shintani, Akinori

AU - Toume, Kazufumi

AU - Rifai, Yusnita

AU - Arai, Midori A.

AU - Ishibashi, Masami

PY - 2010/10/22

Y1 - 2010/10/22

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AB - 6-Hydroxy-9′-methoxystaurosporinone (1), a new bisindole alkaloid, was isolated from field-collected fruiting bodies of the myxomycete Perichaena chrysosperma, together with two known compounds. The structure of the new alkaloid was elucidated from spectral data, and compound 1 was shown to have hedgehog signal inhibitory activity. A related new alkaloid, 6,9′-dihydroxystaurosporinone (4), was also isolated from Arcyria cinerea.

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A bisindole alkaloid with hedgehog signal inhibitory activity from the myxomycete perichaena chrysosperma

Abstract

ASJC Scopus subject areas

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