A bisindole alkaloid with hedgehog signal inhibitory activity from the myxomycete perichaena chrysosperma

Akinori Shintani, Kazufumi Toume, Yusnita Rifai, Midori A. Arai, Masami Ishibashi

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

6-Hydroxy-9′-methoxystaurosporinone (1), a new bisindole alkaloid, was isolated from field-collected fruiting bodies of the myxomycete Perichaena chrysosperma, together with two known compounds. The structure of the new alkaloid was elucidated from spectral data, and compound 1 was shown to have hedgehog signal inhibitory activity. A related new alkaloid, 6,9′-dihydroxystaurosporinone (4), was also isolated from Arcyria cinerea.

Original languageEnglish
Pages (from-to)1711-1713
Number of pages3
JournalJournal of Natural Products
Volume73
Issue number10
DOIs
Publication statusPublished - 2010 Oct 22
Externally publishedYes

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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