A case-matched study of stereotactic radiosurgery for patients with brain metastases

comparing treatment results for those with versus without neurological symptoms

Takao Koiso, Masaaki Yamamoto, Takuya Kawabe, Shinya Watanabe, Yasunori Sato, Yoshinori Higuchi, Tetsuya Yamamoto, Akira Matsumura, Hidetoshi Kasuya, Bierta E. Barfod

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

We aimed to reappraise whether post-stereotactic radiosurgery (SRS) results for brain metastases differ between patients with and without neurological symptoms. This was an institutional review board-approved, retrospective cohort study using our prospectively accumulated database including 2825 consecutive BM patients undergoing gamma knife SRS alone during the 15-year period since July 1998. The 2825 patients were divided into two groups; neurologically asymptomatic [group A, 1374 patients (48.6 %)] and neurologically symptomatic [group B, 1451 (51.4 %)]. Because there was considerable bias in pre-SRS clinical factors between groups A and B, a case-matched study was conducted. Ultimately, 1644 patients (822 in each group) were selected. The standard Kaplan–Meier method was used to determine post-SRS survival. Competing risk analysis was applied to estimate cumulative incidences of neurological death, neurological deterioration, local recurrence, re-SRS for new lesions and SRS-induced complications. Post-SRS median survival times (MSTs) did not differ between the two groups; 7.8 months in group A versus 7.4 months in group B patients (HR 1.064, 95 % CI 0.963–1.177, p = 0.22). However, cumulative incidences of neurological death (HR 1.637, 95 % CI 1.174–2.281, p = 0.0036) and neurological deterioration (HR 1.425, 95 % CI 1.073–1.894, p = 0.014) were significantly lower in the group A than in the group B patients. Neurologically asymptomatic patients undergoing SRS for BM had better results than symptomatic patients in terms of both maintenance of good neurological state and prolonged neurological survival. Thus, we conclude that screening computed tomography/magnetic resonance imaging is highly beneficial for managing cancer patients.

Original languageEnglish
Pages (from-to)581-590
Number of pages10
JournalJournal of Neuro-Oncology
Volume130
Issue number3
DOIs
Publication statusPublished - 2016 Dec 1
Externally publishedYes

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Radiosurgery
Neoplasm Metastasis
Brain
Therapeutics
Survival
Research Ethics Committees
Incidence
Cohort Studies
Retrospective Studies
Tomography
Magnetic Resonance Imaging
Databases
Recurrence

Keywords

  • Brain metastases
  • Gamma knife
  • Metastatic tumor
  • Radiation therapy
  • Radiosurgery

ASJC Scopus subject areas

  • Oncology
  • Neurology
  • Clinical Neurology
  • Cancer Research

Cite this

A case-matched study of stereotactic radiosurgery for patients with brain metastases : comparing treatment results for those with versus without neurological symptoms. / Koiso, Takao; Yamamoto, Masaaki; Kawabe, Takuya; Watanabe, Shinya; Sato, Yasunori; Higuchi, Yoshinori; Yamamoto, Tetsuya; Matsumura, Akira; Kasuya, Hidetoshi; Barfod, Bierta E.

In: Journal of Neuro-Oncology, Vol. 130, No. 3, 01.12.2016, p. 581-590.

Research output: Contribution to journalArticle

Koiso, T, Yamamoto, M, Kawabe, T, Watanabe, S, Sato, Y, Higuchi, Y, Yamamoto, T, Matsumura, A, Kasuya, H & Barfod, BE 2016, 'A case-matched study of stereotactic radiosurgery for patients with brain metastases: comparing treatment results for those with versus without neurological symptoms', Journal of Neuro-Oncology, vol. 130, no. 3, pp. 581-590. https://doi.org/10.1007/s11060-016-2264-0
Koiso, Takao ; Yamamoto, Masaaki ; Kawabe, Takuya ; Watanabe, Shinya ; Sato, Yasunori ; Higuchi, Yoshinori ; Yamamoto, Tetsuya ; Matsumura, Akira ; Kasuya, Hidetoshi ; Barfod, Bierta E. / A case-matched study of stereotactic radiosurgery for patients with brain metastases : comparing treatment results for those with versus without neurological symptoms. In: Journal of Neuro-Oncology. 2016 ; Vol. 130, No. 3. pp. 581-590.
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abstract = "We aimed to reappraise whether post-stereotactic radiosurgery (SRS) results for brain metastases differ between patients with and without neurological symptoms. This was an institutional review board-approved, retrospective cohort study using our prospectively accumulated database including 2825 consecutive BM patients undergoing gamma knife SRS alone during the 15-year period since July 1998. The 2825 patients were divided into two groups; neurologically asymptomatic [group A, 1374 patients (48.6 {\%})] and neurologically symptomatic [group B, 1451 (51.4 {\%})]. Because there was considerable bias in pre-SRS clinical factors between groups A and B, a case-matched study was conducted. Ultimately, 1644 patients (822 in each group) were selected. The standard Kaplan–Meier method was used to determine post-SRS survival. Competing risk analysis was applied to estimate cumulative incidences of neurological death, neurological deterioration, local recurrence, re-SRS for new lesions and SRS-induced complications. Post-SRS median survival times (MSTs) did not differ between the two groups; 7.8 months in group A versus 7.4 months in group B patients (HR 1.064, 95 {\%} CI 0.963–1.177, p = 0.22). However, cumulative incidences of neurological death (HR 1.637, 95 {\%} CI 1.174–2.281, p = 0.0036) and neurological deterioration (HR 1.425, 95 {\%} CI 1.073–1.894, p = 0.014) were significantly lower in the group A than in the group B patients. Neurologically asymptomatic patients undergoing SRS for BM had better results than symptomatic patients in terms of both maintenance of good neurological state and prolonged neurological survival. Thus, we conclude that screening computed tomography/magnetic resonance imaging is highly beneficial for managing cancer patients.",
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AU - Sato, Yasunori

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