A case of advanced gastric cancer with lymphangitis carcinomatosa after operation of Krukenberg tumor treated by TS-1 plus CPT-11 as third-line chemotherapy

Yoshiyuki Yamagishi, Yasutada Akiba, Motoko Izumiya, Hajime Higuchi, Hideko Iizuka, Hiromasa Takaishi, Hiroshi Nagata, Toshifumi Hibi

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Chemotherapies for recurrent gastric cancer have not yet been established. Here we report a case of type 4 gastric cancer associated with lymphangitis carcinomatosis which became refractory to the previous chemotherapies. The case was a 40-year-old woman. She had been diagnosed with gastric cancer after a Krukenberg tumor operation. Chemotherapies (TS-1 plus CDDP as first-line, and TS-1 plus taxanes as second-line) were performed, and a partial response was achieved. Disease activity has been well controlled until this time. Since recurrence of left pleural effusion and lymphangitis carcinomatosis was recognized, we changed the chemotherapy TS-1 plus CPT-11. Pleural effusion decreased and lymphangitis carcinomatosis improved. The serum CA 19-9 level rose transiently after CPT-11 administration, and tended to fall at the second week of chemotherapy. However, the patient died 2 years 4 months after the onset. TS-1 plus CPT-11 combination chemotherapy would be effective for lymphangitis carcinomatosis and also useful as third-line chemotherapy for recurrent gastric cancer.

Original languageEnglish
Pages (from-to)1167-1170
Number of pages4
JournalGan to kagaku ryoho. Cancer & chemotherapy
Volume32
Issue number8
Publication statusPublished - 2005 Aug

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irinotecan
Krukenberg Tumor
Lymphangitis
Stomach Neoplasms
Drug Therapy
Carcinoma
Pleural Effusion
Taxoids
Combination Drug Therapy
titanium silicide

ASJC Scopus subject areas

  • Cancer Research
  • Pharmacology

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A case of advanced gastric cancer with lymphangitis carcinomatosa after operation of Krukenberg tumor treated by TS-1 plus CPT-11 as third-line chemotherapy. / Yamagishi, Yoshiyuki; Akiba, Yasutada; Izumiya, Motoko; Higuchi, Hajime; Iizuka, Hideko; Takaishi, Hiromasa; Nagata, Hiroshi; Hibi, Toshifumi.

In: Gan to kagaku ryoho. Cancer & chemotherapy, Vol. 32, No. 8, 08.2005, p. 1167-1170.

Research output: Contribution to journalArticle

Yamagishi, Yoshiyuki ; Akiba, Yasutada ; Izumiya, Motoko ; Higuchi, Hajime ; Iizuka, Hideko ; Takaishi, Hiromasa ; Nagata, Hiroshi ; Hibi, Toshifumi. / A case of advanced gastric cancer with lymphangitis carcinomatosa after operation of Krukenberg tumor treated by TS-1 plus CPT-11 as third-line chemotherapy. In: Gan to kagaku ryoho. Cancer & chemotherapy. 2005 ; Vol. 32, No. 8. pp. 1167-1170.
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abstract = "Chemotherapies for recurrent gastric cancer have not yet been established. Here we report a case of type 4 gastric cancer associated with lymphangitis carcinomatosis which became refractory to the previous chemotherapies. The case was a 40-year-old woman. She had been diagnosed with gastric cancer after a Krukenberg tumor operation. Chemotherapies (TS-1 plus CDDP as first-line, and TS-1 plus taxanes as second-line) were performed, and a partial response was achieved. Disease activity has been well controlled until this time. Since recurrence of left pleural effusion and lymphangitis carcinomatosis was recognized, we changed the chemotherapy TS-1 plus CPT-11. Pleural effusion decreased and lymphangitis carcinomatosis improved. The serum CA 19-9 level rose transiently after CPT-11 administration, and tended to fall at the second week of chemotherapy. However, the patient died 2 years 4 months after the onset. TS-1 plus CPT-11 combination chemotherapy would be effective for lymphangitis carcinomatosis and also useful as third-line chemotherapy for recurrent gastric cancer.",
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AU - Izumiya, Motoko

AU - Higuchi, Hajime

AU - Iizuka, Hideko

AU - Takaishi, Hiromasa

AU - Nagata, Hiroshi

AU - Hibi, Toshifumi

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N2 - Chemotherapies for recurrent gastric cancer have not yet been established. Here we report a case of type 4 gastric cancer associated with lymphangitis carcinomatosis which became refractory to the previous chemotherapies. The case was a 40-year-old woman. She had been diagnosed with gastric cancer after a Krukenberg tumor operation. Chemotherapies (TS-1 plus CDDP as first-line, and TS-1 plus taxanes as second-line) were performed, and a partial response was achieved. Disease activity has been well controlled until this time. Since recurrence of left pleural effusion and lymphangitis carcinomatosis was recognized, we changed the chemotherapy TS-1 plus CPT-11. Pleural effusion decreased and lymphangitis carcinomatosis improved. The serum CA 19-9 level rose transiently after CPT-11 administration, and tended to fall at the second week of chemotherapy. However, the patient died 2 years 4 months after the onset. TS-1 plus CPT-11 combination chemotherapy would be effective for lymphangitis carcinomatosis and also useful as third-line chemotherapy for recurrent gastric cancer.

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