A Case of Aldosterone Producing Adenoma Associated with High PRA after Long-Term Angiotensin Converting Enzyme Inhibitor Treatment

Akira Kasuga, Izumi Takei, Sadatomo Tasaka, Hirotaka Shibata, Hiroshi Maruyama, Takao Saruta, Kunizo Kataoka

Research output: Contribution to journalArticle


A 62-year-old patient with non-insulin dependent diabetes (NIDDM) was admitted to our hospital for blood pressure control. He had been treated with angiotensin converting enzyme inhibitor (ACEI) for 7 years and showed marked hypokalemia with increased urinary potassium excretion. Hormonal examination revealed a normal plasma aldosterone concentration and increased plasma renin activity (PRA, 13.4ng/ml/h), so potassium losing nephropathy was suspected. After discontinuation of the ACEI, PRA decreased to normal. An adrenal adenoma was found on abdominal magnetic resonance imaging (MRI) and adrenalectomy was performed to confirm aldosterone producing adenoma (APA). Although ACEIs are said not to alter PRA in APA, this drug was primarily responsible for the increased PRA in this case. This is a rare case of APA, which showed markedly increased PRA during ACEI treatment.

Original languageEnglish
Pages (from-to)47-52
Number of pages6
JournalEndocrine journal
Issue number1
Publication statusPublished - 1993 Jan 1



  • Aldosterone producing adenoma
  • Angiotensin converting enzyme inhibitor
  • Hypokalemia
  • Plasma renin activity

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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