A case of angiosarcoma that developed 10 years after postoperative radiotherapy for tongue cancer

Hitomi Sagae, Yoshihiro Watanabe, Hiroyuki Ozawa, Kaoru Ogawa

Research output: Contribution to journalArticle

Abstract

Angiosarcoma is a rare disease that accounts for about 1%-2% of all soft-tissue sarcomas and is a highly malignant tumor with a poor prognosis. Albeit not very common, in some cases, angiosarcomas can be induced by irradiation. In this study, we report the case of a patient who developed angiosarcoma at the site of previous postoperative radiotherapy for tongue cancer. The patient was a 63-year-old woman who had undergone surgery for tongue cancer (T4aN2cM0) and received irradiation (50 Gy in total) to the cervical region. The postoperative course had been uneventful, without recurrence. However, 10 years after the surgery, she began to develop a dark-red tumor in the right lower jaw, which was diagnosed as angiosarcoma by biopsy. Because imaging revealed evidence of neither lymph node metastasis nor distant metastasis, tumorectomy with reconstructive surgery using a pectoralis major myocutaneous flap was performed. She then received postoperative adjuvant chemotherapy. Thereafter, she has had an uneventful course, without any evidence of recurrence until date. This case serves to underscore the fact that exposure to radiation can result in new malignant tumor formation. Therefore, such patients need to be explained about the possibility of development of radiation-induced tumor and about the need for long-term follow-up after radiotherapy; they should also receive instructions to visit a medical facility in case they notice any abnormality at the site of previous irradiation. In the event a patient develops any abnormality, such as redness and/or swelling, at the site of previous irradiation, he/she a patient should immediately be worked up under the assumption of not only recurrence of the primary disease, but also possible radiation-induced tumor. The diagnosis must be established by methods such as biopsy.

Original languageEnglish
Pages (from-to)88-89
Number of pages2
JournalPractica Otologica, Supplement
Volume152
DOIs
Publication statusPublished - 2018 Jan 1

Fingerprint

Tongue Neoplasms
Hemangiosarcoma
Radiotherapy
Neoplasms
Recurrence
Reconstructive Surgical Procedures
Radiation
Neoplasm Metastasis
Biopsy
Myocutaneous Flap
Adjuvant Chemotherapy
Rare Diseases
Jaw
Sarcoma
Lymph Nodes

Keywords

  • Angiosarcoma
  • Radiation-induced tumor
  • Radiotherapy
  • Tongue cancer

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

A case of angiosarcoma that developed 10 years after postoperative radiotherapy for tongue cancer. / Sagae, Hitomi; Watanabe, Yoshihiro; Ozawa, Hiroyuki; Ogawa, Kaoru.

In: Practica Otologica, Supplement, Vol. 152, 01.01.2018, p. 88-89.

Research output: Contribution to journalArticle

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