A case of atypical POEMS syndrome without polyneuropathy

Ryuji Morizane, Hiroyuki Sasamura, Hitoshi Minakuchi, Yujiro Takae, Haruhito Kikuchi, Naomi Yoshiya, Akinori Hashiguchi, Konosuke Konishi, Shinichiro Okamoto, Hiroshi Itoh

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

POEMS (Polyneuropathy, Organomegaly, Endocrinopathy, M-protein, Skin changes) syndrome is a rare hematological disease associated with overproduction of pro-inflammatory cytokines. Under the current nomenclature and diagnostic criteria for POEMS syndrome, the presence of characteristic polyneuropathy is required for diagnosis. We report a 43-year-old Japanese woman with organomegaly, endocrinopathy, M-protein, skin lesions, as well as typical renal lesions and sclerotic bone lesions. Of note, neurological examinations and peripheral nerve conduction tests were normal in this patient. In view of the overwhelming number of otherwise characteristic signs and symptoms, we made a provisional diagnosis of 'atypical POEMS syndrome without polyneuropathy'. If further similar cases are reported in the future, reconsideration of the nomenclature and/or diagnostic criteria for POEMS syndrome may be required.

Original languageEnglish
Pages (from-to)452-455
Number of pages4
JournalEuropean Journal of Haematology
Volume80
Issue number5
DOIs
Publication statusPublished - 2008 May 1

Keywords

  • Neuropathy
  • Osteosclerotic myeloma
  • POEMS syndrome

ASJC Scopus subject areas

  • Hematology

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  • Cite this

    Morizane, R., Sasamura, H., Minakuchi, H., Takae, Y., Kikuchi, H., Yoshiya, N., Hashiguchi, A., Konishi, K., Okamoto, S., & Itoh, H. (2008). A case of atypical POEMS syndrome without polyneuropathy. European Journal of Haematology, 80(5), 452-455. https://doi.org/10.1111/j.1600-0609.2008.01045.x