A case of atypical POEMS syndrome without polyneuropathy

Ryuji Morizane, Hiroyuki Sasamura, Hitoshi Minakuchi, Yujiro Takae, Haruhito Kikuchi, Naomi Yoshiya, Akinori Hashiguchi, Konosuke Konishi, Shinichiro Okamoto, Hiroshi Itoh

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

POEMS (Polyneuropathy, Organomegaly, Endocrinopathy, M-protein, Skin changes) syndrome is a rare hematological disease associated with overproduction of pro-inflammatory cytokines. Under the current nomenclature and diagnostic criteria for POEMS syndrome, the presence of characteristic polyneuropathy is required for diagnosis. We report a 43-year-old Japanese woman with organomegaly, endocrinopathy, M-protein, skin lesions, as well as typical renal lesions and sclerotic bone lesions. Of note, neurological examinations and peripheral nerve conduction tests were normal in this patient. In view of the overwhelming number of otherwise characteristic signs and symptoms, we made a provisional diagnosis of 'atypical POEMS syndrome without polyneuropathy'. If further similar cases are reported in the future, reconsideration of the nomenclature and/or diagnostic criteria for POEMS syndrome may be required.

Original languageEnglish
Pages (from-to)452-455
Number of pages4
JournalEuropean Journal of Haematology
Volume80
Issue number5
DOIs
Publication statusPublished - 2008 May

Fingerprint

POEMS Syndrome
Polyneuropathies
Terminology
Hematologic Diseases
Neural Conduction
Neurologic Examination
Rare Diseases
Peripheral Nerves
Signs and Symptoms
Cytokines
Kidney
Bone and Bones
Skin
Proteins

Keywords

  • Neuropathy
  • Osteosclerotic myeloma
  • POEMS syndrome

ASJC Scopus subject areas

  • Hematology

Cite this

A case of atypical POEMS syndrome without polyneuropathy. / Morizane, Ryuji; Sasamura, Hiroyuki; Minakuchi, Hitoshi; Takae, Yujiro; Kikuchi, Haruhito; Yoshiya, Naomi; Hashiguchi, Akinori; Konishi, Konosuke; Okamoto, Shinichiro; Itoh, Hiroshi.

In: European Journal of Haematology, Vol. 80, No. 5, 05.2008, p. 452-455.

Research output: Contribution to journalArticle

Morizane, Ryuji ; Sasamura, Hiroyuki ; Minakuchi, Hitoshi ; Takae, Yujiro ; Kikuchi, Haruhito ; Yoshiya, Naomi ; Hashiguchi, Akinori ; Konishi, Konosuke ; Okamoto, Shinichiro ; Itoh, Hiroshi. / A case of atypical POEMS syndrome without polyneuropathy. In: European Journal of Haematology. 2008 ; Vol. 80, No. 5. pp. 452-455.
@article{af9d25d3c1564cbfac95a7b0ca4d7228,
title = "A case of atypical POEMS syndrome without polyneuropathy",
abstract = "POEMS (Polyneuropathy, Organomegaly, Endocrinopathy, M-protein, Skin changes) syndrome is a rare hematological disease associated with overproduction of pro-inflammatory cytokines. Under the current nomenclature and diagnostic criteria for POEMS syndrome, the presence of characteristic polyneuropathy is required for diagnosis. We report a 43-year-old Japanese woman with organomegaly, endocrinopathy, M-protein, skin lesions, as well as typical renal lesions and sclerotic bone lesions. Of note, neurological examinations and peripheral nerve conduction tests were normal in this patient. In view of the overwhelming number of otherwise characteristic signs and symptoms, we made a provisional diagnosis of 'atypical POEMS syndrome without polyneuropathy'. If further similar cases are reported in the future, reconsideration of the nomenclature and/or diagnostic criteria for POEMS syndrome may be required.",
keywords = "Neuropathy, Osteosclerotic myeloma, POEMS syndrome",
author = "Ryuji Morizane and Hiroyuki Sasamura and Hitoshi Minakuchi and Yujiro Takae and Haruhito Kikuchi and Naomi Yoshiya and Akinori Hashiguchi and Konosuke Konishi and Shinichiro Okamoto and Hiroshi Itoh",
year = "2008",
month = "5",
doi = "10.1111/j.1600-0609.2008.01045.x",
language = "English",
volume = "80",
pages = "452--455",
journal = "European Journal of Haematology",
issn = "0902-4441",
publisher = "Wiley-Blackwell",
number = "5",

}

TY - JOUR

T1 - A case of atypical POEMS syndrome without polyneuropathy

AU - Morizane, Ryuji

AU - Sasamura, Hiroyuki

AU - Minakuchi, Hitoshi

AU - Takae, Yujiro

AU - Kikuchi, Haruhito

AU - Yoshiya, Naomi

AU - Hashiguchi, Akinori

AU - Konishi, Konosuke

AU - Okamoto, Shinichiro

AU - Itoh, Hiroshi

PY - 2008/5

Y1 - 2008/5

N2 - POEMS (Polyneuropathy, Organomegaly, Endocrinopathy, M-protein, Skin changes) syndrome is a rare hematological disease associated with overproduction of pro-inflammatory cytokines. Under the current nomenclature and diagnostic criteria for POEMS syndrome, the presence of characteristic polyneuropathy is required for diagnosis. We report a 43-year-old Japanese woman with organomegaly, endocrinopathy, M-protein, skin lesions, as well as typical renal lesions and sclerotic bone lesions. Of note, neurological examinations and peripheral nerve conduction tests were normal in this patient. In view of the overwhelming number of otherwise characteristic signs and symptoms, we made a provisional diagnosis of 'atypical POEMS syndrome without polyneuropathy'. If further similar cases are reported in the future, reconsideration of the nomenclature and/or diagnostic criteria for POEMS syndrome may be required.

AB - POEMS (Polyneuropathy, Organomegaly, Endocrinopathy, M-protein, Skin changes) syndrome is a rare hematological disease associated with overproduction of pro-inflammatory cytokines. Under the current nomenclature and diagnostic criteria for POEMS syndrome, the presence of characteristic polyneuropathy is required for diagnosis. We report a 43-year-old Japanese woman with organomegaly, endocrinopathy, M-protein, skin lesions, as well as typical renal lesions and sclerotic bone lesions. Of note, neurological examinations and peripheral nerve conduction tests were normal in this patient. In view of the overwhelming number of otherwise characteristic signs and symptoms, we made a provisional diagnosis of 'atypical POEMS syndrome without polyneuropathy'. If further similar cases are reported in the future, reconsideration of the nomenclature and/or diagnostic criteria for POEMS syndrome may be required.

KW - Neuropathy

KW - Osteosclerotic myeloma

KW - POEMS syndrome

UR - http://www.scopus.com/inward/record.url?scp=41849097753&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=41849097753&partnerID=8YFLogxK

U2 - 10.1111/j.1600-0609.2008.01045.x

DO - 10.1111/j.1600-0609.2008.01045.x

M3 - Article

C2 - 18284621

AN - SCOPUS:41849097753

VL - 80

SP - 452

EP - 455

JO - European Journal of Haematology

JF - European Journal of Haematology

SN - 0902-4441

IS - 5

ER -