A case of central nervous system lymphomatoid granulomatosis; characteristics of PET imaging and pathological findings

Hiroshi Nishihara, Matsuyoshi Nakasato, Hiroki Sawa, Hiromi Murakami, Daisuke Yamamoto, Kenji Moriyama, Norifumi Kato, Ikuo Hashimoto, Hajime Kamada, Shinya Tanaka

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Lymphomatoid granulomatosis (LYG) in the central nervous system (CNS) is an uncommon lymphoproliferative disorder with low grade malignant potential. Here we report a case of CNS-LYG, in particular, its characteristics of radioisotope imaging and pathological findings. A 65-year-old man complained of visual disturbance and homonymous hemianopsia was designated. CT and MRI revealed an edematous, enhanced irregular and nodular lesion in the right occipital and parietal lobes. Although 18F-fluorodeoxyglucose (FDG)-positron emission tomography (PET) scan showed low uptake in the lesion, Methionine (MET)-PET scan indicated high uptake. Proton magnetic resonance spectroscopy (1H-MRS) at 3T revealed a decrease of the peak of the N-acetylaspartate (NAA), suggesting a possible neoplastic lesion. The patient was diagnosed with CNS-LYG based on the surgically removed material showing perivascular infiltration of CD3-positive small T-lymphocytes with granulomatous lesions. The post-operative steroid therapy was effective and the recurrence or exacerbation has not been observed by radiological imaging until now.

Original languageEnglish
Pages (from-to)275-278
Number of pages4
JournalJournal of Neuro-Oncology
Volume93
Issue number2
DOIs
Publication statusPublished - 2009 Jan 1
Externally publishedYes

Fingerprint

Lymphomatoid Granulomatosis
Positron-Emission Tomography
Central Nervous System
Hemianopsia
Occipital Lobe
Parietal Lobe
Lymphoproliferative Disorders
Fluorodeoxyglucose F18
Radioisotopes
Methionine
Steroids
T-Lymphocytes
Recurrence
Proton Magnetic Resonance Spectroscopy
Therapeutics

Keywords

  • FDG-PET
  • Lymphomatoid granulomatosis
  • MET-PET

ASJC Scopus subject areas

  • Oncology
  • Neurology
  • Clinical Neurology
  • Cancer Research

Cite this

A case of central nervous system lymphomatoid granulomatosis; characteristics of PET imaging and pathological findings. / Nishihara, Hiroshi; Nakasato, Matsuyoshi; Sawa, Hiroki; Murakami, Hiromi; Yamamoto, Daisuke; Moriyama, Kenji; Kato, Norifumi; Hashimoto, Ikuo; Kamada, Hajime; Tanaka, Shinya.

In: Journal of Neuro-Oncology, Vol. 93, No. 2, 01.01.2009, p. 275-278.

Research output: Contribution to journalArticle

Nishihara, H, Nakasato, M, Sawa, H, Murakami, H, Yamamoto, D, Moriyama, K, Kato, N, Hashimoto, I, Kamada, H & Tanaka, S 2009, 'A case of central nervous system lymphomatoid granulomatosis; characteristics of PET imaging and pathological findings', Journal of Neuro-Oncology, vol. 93, no. 2, pp. 275-278. https://doi.org/10.1007/s11060-008-9771-6
Nishihara, Hiroshi ; Nakasato, Matsuyoshi ; Sawa, Hiroki ; Murakami, Hiromi ; Yamamoto, Daisuke ; Moriyama, Kenji ; Kato, Norifumi ; Hashimoto, Ikuo ; Kamada, Hajime ; Tanaka, Shinya. / A case of central nervous system lymphomatoid granulomatosis; characteristics of PET imaging and pathological findings. In: Journal of Neuro-Oncology. 2009 ; Vol. 93, No. 2. pp. 275-278.
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