Abstract
Astroblastoma is a rare neuroepithelial neoplasm of unknown origin, usually occurring in children and young adults. Here we report a case of astroblastoma with uncommon features in an 18-year-old female. The tumor was a well-circumscribed cystic and solid mass with marked gadolinium enhancement in the right frontal lobe. Cytological examination showed polarized monopolar cells with diminished cohesiveness. Tumor cells possessed eccentric round to oval nuclei with abundant eosinophilic cytoplasm, sometimes having cytoplasmic processes. Histopathologically, the tumor showed perivascular pseudorosettes with prominent vascular sclerosis. Foam cells were frequently infiltrated around blood vessels and among tumor cells. In some areas, a solid growth pattern of plump tumor cells with abundant inclusion-like eosinophilic cytoplasm showing rhabdoid appearance was observed. The immunohistochemical study revealed strong and diffuse positivity for vimentin and epithelial membrane antigen. Tumor cells were focally positive for glial fibrillary acidic protein and cytokeratin AE1/AE3. Nuclear immunoreactivity for INI1 protein was evident. The Ki-67 labeling index was 10.8 %. This tumor was finally diagnosed as low-grade astroblastoma and the patient had no evidence of recurrence without postoperative radiotherapy or chemotherapy during the last 6 months of follow-up. This report describes novel cytological, histopathological, and immunohistochemical features of the rare tumor.
| Original language | English |
|---|---|
| Pages (from-to) | 63-70 |
| Number of pages | 8 |
| Journal | Brain tumor pathology |
| Volume | 33 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 2016 Jan 1 |
| Externally published | Yes |
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Keywords
- Astroblastoma
- Cytology
- Foam cell
- Rhabdoid
ASJC Scopus subject areas
- Oncology
- Clinical Neurology
- Cancer Research
Cite this
A case of cerebral astroblastoma with rhabdoid features : a cytological, histological, and immunohistochemical study. / Yuzawa, Sayaka; Nishihara, Hiroshi; Tanino, Mishie; Kimura, Taichi; Moriya, Jun; Kamoshima, Yuuta; Nagashima, Kazuo; Tanaka, Shinya.
In: Brain tumor pathology, Vol. 33, No. 1, 01.01.2016, p. 63-70.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - A case of cerebral astroblastoma with rhabdoid features
T2 - a cytological, histological, and immunohistochemical study
AU - Yuzawa, Sayaka
AU - Nishihara, Hiroshi
AU - Tanino, Mishie
AU - Kimura, Taichi
AU - Moriya, Jun
AU - Kamoshima, Yuuta
AU - Nagashima, Kazuo
AU - Tanaka, Shinya
PY - 2016/1/1
Y1 - 2016/1/1
N2 - Astroblastoma is a rare neuroepithelial neoplasm of unknown origin, usually occurring in children and young adults. Here we report a case of astroblastoma with uncommon features in an 18-year-old female. The tumor was a well-circumscribed cystic and solid mass with marked gadolinium enhancement in the right frontal lobe. Cytological examination showed polarized monopolar cells with diminished cohesiveness. Tumor cells possessed eccentric round to oval nuclei with abundant eosinophilic cytoplasm, sometimes having cytoplasmic processes. Histopathologically, the tumor showed perivascular pseudorosettes with prominent vascular sclerosis. Foam cells were frequently infiltrated around blood vessels and among tumor cells. In some areas, a solid growth pattern of plump tumor cells with abundant inclusion-like eosinophilic cytoplasm showing rhabdoid appearance was observed. The immunohistochemical study revealed strong and diffuse positivity for vimentin and epithelial membrane antigen. Tumor cells were focally positive for glial fibrillary acidic protein and cytokeratin AE1/AE3. Nuclear immunoreactivity for INI1 protein was evident. The Ki-67 labeling index was 10.8 %. This tumor was finally diagnosed as low-grade astroblastoma and the patient had no evidence of recurrence without postoperative radiotherapy or chemotherapy during the last 6 months of follow-up. This report describes novel cytological, histopathological, and immunohistochemical features of the rare tumor.
AB - Astroblastoma is a rare neuroepithelial neoplasm of unknown origin, usually occurring in children and young adults. Here we report a case of astroblastoma with uncommon features in an 18-year-old female. The tumor was a well-circumscribed cystic and solid mass with marked gadolinium enhancement in the right frontal lobe. Cytological examination showed polarized monopolar cells with diminished cohesiveness. Tumor cells possessed eccentric round to oval nuclei with abundant eosinophilic cytoplasm, sometimes having cytoplasmic processes. Histopathologically, the tumor showed perivascular pseudorosettes with prominent vascular sclerosis. Foam cells were frequently infiltrated around blood vessels and among tumor cells. In some areas, a solid growth pattern of plump tumor cells with abundant inclusion-like eosinophilic cytoplasm showing rhabdoid appearance was observed. The immunohistochemical study revealed strong and diffuse positivity for vimentin and epithelial membrane antigen. Tumor cells were focally positive for glial fibrillary acidic protein and cytokeratin AE1/AE3. Nuclear immunoreactivity for INI1 protein was evident. The Ki-67 labeling index was 10.8 %. This tumor was finally diagnosed as low-grade astroblastoma and the patient had no evidence of recurrence without postoperative radiotherapy or chemotherapy during the last 6 months of follow-up. This report describes novel cytological, histopathological, and immunohistochemical features of the rare tumor.
KW - Astroblastoma
KW - Cytology
KW - Foam cell
KW - Rhabdoid
UR - http://www.scopus.com/inward/record.url?scp=84953360737&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84953360737&partnerID=8YFLogxK
U2 - 10.1007/s10014-015-0241-5
DO - 10.1007/s10014-015-0241-5
M3 - Article
C2 - 26614252
AN - SCOPUS:84953360737
VL - 33
SP - 63
EP - 70
JO - Brain Tumor Pathology
JF - Brain Tumor Pathology
SN - 1433-7398
IS - 1
ER -