A case of cerebral astroblastoma with rhabdoid features: a cytological, histological, and immunohistochemical study

Sayaka Yuzawa, Hiroshi Nishihara, Mishie Tanino, Taichi Kimura, Jun Moriya, Yuuta Kamoshima, Kazuo Nagashima, Shinya Tanaka

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Astroblastoma is a rare neuroepithelial neoplasm of unknown origin, usually occurring in children and young adults. Here we report a case of astroblastoma with uncommon features in an 18-year-old female. The tumor was a well-circumscribed cystic and solid mass with marked gadolinium enhancement in the right frontal lobe. Cytological examination showed polarized monopolar cells with diminished cohesiveness. Tumor cells possessed eccentric round to oval nuclei with abundant eosinophilic cytoplasm, sometimes having cytoplasmic processes. Histopathologically, the tumor showed perivascular pseudorosettes with prominent vascular sclerosis. Foam cells were frequently infiltrated around blood vessels and among tumor cells. In some areas, a solid growth pattern of plump tumor cells with abundant inclusion-like eosinophilic cytoplasm showing rhabdoid appearance was observed. The immunohistochemical study revealed strong and diffuse positivity for vimentin and epithelial membrane antigen. Tumor cells were focally positive for glial fibrillary acidic protein and cytokeratin AE1/AE3. Nuclear immunoreactivity for INI1 protein was evident. The Ki-67 labeling index was 10.8 %. This tumor was finally diagnosed as low-grade astroblastoma and the patient had no evidence of recurrence without postoperative radiotherapy or chemotherapy during the last 6 months of follow-up. This report describes novel cytological, histopathological, and immunohistochemical features of the rare tumor.

Original languageEnglish
Pages (from-to)63-70
Number of pages8
JournalBrain tumor pathology
Volume33
Issue number1
DOIs
Publication statusPublished - 2016 Jan 1
Externally publishedYes

Fingerprint

Neuroepithelial Neoplasms
Neoplasms
Cytoplasm
Vascular Tissue Neoplasms
Mucin-1
Foam Cells
Arteriosclerosis
Glial Fibrillary Acidic Protein
Gadolinium
Frontal Lobe
Vimentin
Keratins
Young Adult
Radiotherapy
Recurrence
Drug Therapy
Growth

Keywords

  • Astroblastoma
  • Cytology
  • Foam cell
  • Rhabdoid

ASJC Scopus subject areas

  • Oncology
  • Clinical Neurology
  • Cancer Research

Cite this

A case of cerebral astroblastoma with rhabdoid features : a cytological, histological, and immunohistochemical study. / Yuzawa, Sayaka; Nishihara, Hiroshi; Tanino, Mishie; Kimura, Taichi; Moriya, Jun; Kamoshima, Yuuta; Nagashima, Kazuo; Tanaka, Shinya.

In: Brain tumor pathology, Vol. 33, No. 1, 01.01.2016, p. 63-70.

Research output: Contribution to journalArticle

Yuzawa, Sayaka ; Nishihara, Hiroshi ; Tanino, Mishie ; Kimura, Taichi ; Moriya, Jun ; Kamoshima, Yuuta ; Nagashima, Kazuo ; Tanaka, Shinya. / A case of cerebral astroblastoma with rhabdoid features : a cytological, histological, and immunohistochemical study. In: Brain tumor pathology. 2016 ; Vol. 33, No. 1. pp. 63-70.
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