A case of cerebral ganglioneuronal tumor in the parietal lobe of an adult

Hiroshi Nishihara, Yoshimaru Ozaki, Tamio Ito, Tomoaki Yoshinaga, Kouichi Tabu, Mishie Tanino, Kazuo Nagashima, Shinya Tanaka

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Central nervous system (CNS) neuroblastoma/ganglioneuroblastoma is one of the embryonal tumors with neuronal differentiation found in young adults, but it is most common in children, especially in those below the age of 5 years, whereas extraventricular neurocytoma, a rare neuroepithelial tumor with neuronal differentiation, mostly affects young adults. Here we present a rare case of cerebral ganglioneuronal tumor that occurred in a 32-year-old woman. The patient suffered from tonic convulsion, and computed tomography demonstrated a well-demarcated, round tumor 3.3 cm in size with marked calcification in the right parietal lobe. Histological analysis revealed diffuse infiltration of small, round cells with scattered large ganglion-like cells. Immunohistochemically, the tumor cells did not react with any neuronal molecules, except for chromogranin A in ganglion-like large tumor cells, but electron microscopy demonstrated the presence of synapse-like nerve terminal structures without mature postsynaptic density, suggesting the presence of neoplastic tumor components with neuronal differentiation; thus, this tumor was diagnosed as CNS ganglioneuroblastoma with possible low-grade malignancy because the Mib-1 labeling index was less than 3%-4%. Here we discuss the histological entity of cerebral ganglioneuronal tumors, including extraventricular neurocytoma.

Original languageEnglish
Pages (from-to)45-49
Number of pages5
JournalBrain tumor pathology
Volume25
Issue number1
DOIs
Publication statusPublished - 2008 Dec 1
Externally publishedYes

Fingerprint

Parietal Lobe
Neoplasms
Neurocytoma
Ganglioneuroblastoma
Ganglia
Young Adult
Central Nervous System
Neuroepithelial Neoplasms
Post-Synaptic Density
Chromogranin A
Neuroblastoma
Synapses
Electron Microscopy
Seizures
Tomography

Keywords

  • Electron microscope
  • Extraventricular neurocytoma
  • Ganglioneuroblastoma
  • Immunohistochemistry

ASJC Scopus subject areas

  • Oncology
  • Clinical Neurology
  • Cancer Research

Cite this

Nishihara, H., Ozaki, Y., Ito, T., Yoshinaga, T., Tabu, K., Tanino, M., ... Tanaka, S. (2008). A case of cerebral ganglioneuronal tumor in the parietal lobe of an adult. Brain tumor pathology, 25(1), 45-49. https://doi.org/10.1007/s10014-008-0229-5

A case of cerebral ganglioneuronal tumor in the parietal lobe of an adult. / Nishihara, Hiroshi; Ozaki, Yoshimaru; Ito, Tamio; Yoshinaga, Tomoaki; Tabu, Kouichi; Tanino, Mishie; Nagashima, Kazuo; Tanaka, Shinya.

In: Brain tumor pathology, Vol. 25, No. 1, 01.12.2008, p. 45-49.

Research output: Contribution to journalArticle

Nishihara, H, Ozaki, Y, Ito, T, Yoshinaga, T, Tabu, K, Tanino, M, Nagashima, K & Tanaka, S 2008, 'A case of cerebral ganglioneuronal tumor in the parietal lobe of an adult', Brain tumor pathology, vol. 25, no. 1, pp. 45-49. https://doi.org/10.1007/s10014-008-0229-5
Nishihara, Hiroshi ; Ozaki, Yoshimaru ; Ito, Tamio ; Yoshinaga, Tomoaki ; Tabu, Kouichi ; Tanino, Mishie ; Nagashima, Kazuo ; Tanaka, Shinya. / A case of cerebral ganglioneuronal tumor in the parietal lobe of an adult. In: Brain tumor pathology. 2008 ; Vol. 25, No. 1. pp. 45-49.
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