A Case of Childhood Blastic Phase Chronic Myeloid Leukemia with Minor BCR-ABL

Junko Yamanaka, Mariko Shimizu, Maho Sato, Masami Inoue, Motohiro Matsui, Hiroyuki Shimada, Hiroyuki Shichino

Research output: Contribution to journalArticle

Abstract

Chronic myeloid leukemia (CML) is commonly associated with major BCR-ABL transcript. We present a child with blastic phase CML associated with minor BCR-ABL transcript without prior CML diagnosis. Diagnosis was achieved by fluorescence in situ hybridization of peripheral blood neutrophils, which identified 90% as BCR-ABL positive. The patient received chemotherapy with imatinib followed by dasatinib and underwent reduced-intensity hematopoietic allogeneic stem cell transplantation with prophylactic posttransplant dasatinib for 2 years and has remained in complete molecular remission. Our intensified treatment regimen was effective compared with previous studies on minor BCR-ABL CML describing inferior outcomes with tyrosine kinase inhibitor therapy.

Original languageEnglish
JournalJournal of Pediatric Hematology/Oncology
DOIs
Publication statusPublished - 2019 Jan 1

Keywords

  • blastic phase
  • chronic myeloid leukemia
  • minor BCR-ABL fusion gene transcription
  • reduced-intensity hematopoietic stem cell transplantation
  • tyrosine kinase inhibitor

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Hematology
  • Oncology

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