A case of complete response treated by S-1 with concurrent radiotherapy for a gefitinib-resistant non-small cell lung cancer patient

Hiroyuki Fujimoto, Takahiko Oyama, Tetsushi Suito, Kohei Hashimoto, Youju Kameyama, Hiroyuki Yasuda, Hiroshi Ishizuka

Research output: Contribution to journalArticle

Abstract

A 35-year-old woman with a clinical diagnosis of stage T2N2M0 lung adenocarcinoma received 3 courses of preoperative chemotherapy with cisplatin and docetaxel. The treatment response was no change. A left inferior lobectomy with mediastinal and hilar lymph-node dissection (ND2a) was performed. The pathological diagnosis was stage T2N2M0 lung cancer. Gefitinib was administered postoperatively. After 2 months of oral treatment, gefitinib was discontinued because of enlarged subcarinal lymph nodes and an elevated level of serum Sialyl LewisX-i antigen (SLX). Starting 4 months after surgery, the mediastinum was irradiated with a total dose of 50 Gy. Chemotherapy with S-1 was started 5 months after surgery. S-1 was administered in a dose of 100 mg/day in two divided doses for 4 weeks, followed by 2 weeks of rest. The patient received 6 courses of chemotherapy with S-1, without increasing the dose. The enlarged mediastinal lymph nodes disappeared, and the serum SLX level returned to normal. The patient had a complete response, and was subsequently followed on an outpatient basis while receiving oral UFT. More than 36 months have elapsed since surgery, with no evidence of recurrence.

Original languageEnglish
Pages (from-to)295-298
Number of pages4
JournalJapanese Journal of Cancer and Chemotherapy
Volume37
Issue number2
Publication statusPublished - 2010 Feb

Keywords

  • Fluorouracil
  • Gefitinib-resistant
  • Lung adenocarcinoma
  • Non-small cell lung cancer
  • S-1
  • UFT

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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  • Cite this

    Fujimoto, H., Oyama, T., Suito, T., Hashimoto, K., Kameyama, Y., Yasuda, H., & Ishizuka, H. (2010). A case of complete response treated by S-1 with concurrent radiotherapy for a gefitinib-resistant non-small cell lung cancer patient. Japanese Journal of Cancer and Chemotherapy, 37(2), 295-298.