A Case of Cowden's Disease Without Typical Skin Eruptions

Toshifumi Hibi, Atsushi Hayashi, Hiromasa Takaishi, Nagamu Inoue, Yoshitaka Ueno, Yasuo Hosoda, Mamoru Watanabe, Hiromasa Ishii, Takashi Inoue, Makio Mukai

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

A 21-year-old man was admitted to our hospital hoping for the follow-up of gastric polyps. X-ray and endoscopic examinations revealed multiple polypoid lesions in the esophagus, and multiple polyps in the stomach and colon. Esophageal epithelial thickening was demonstrated in the esophageal polypoid lesions. Gastric and colonic hyperplastic polyps were confirmed histologically. Although typical skin findings were absent, Cowden's disease was strongly suggested by clinical features such as adenoid appearance, goiter, arteriovenous malformation and gingival papillomatosis. Cowden's disease is characterized by multiple hyperplastic or hamartomatous development originating from three embryonic germ layers in the whole body. Cowden's disease is frequently complicated with malignant tumors and should be considered in the differential diagnosis of various diseases with gastrointestinal polyposis.

Original languageEnglish
Pages (from-to)65-71
Number of pages7
JournalGastroenterological Endoscopy
Volume37
Issue number1
DOIs
Publication statusPublished - 1995
Externally publishedYes

Fingerprint

Multiple Hamartoma Syndrome
Stomach
Polyps
Skin
Colonic Polyps
Adenoids
Germ Layers
Gastrointestinal Diseases
Arteriovenous Malformations
Goiter
Papilloma
Esophagus
Colon
Differential Diagnosis
X-Rays
Neoplasms

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Gastroenterology

Cite this

A Case of Cowden's Disease Without Typical Skin Eruptions. / Hibi, Toshifumi; Hayashi, Atsushi; Takaishi, Hiromasa; Inoue, Nagamu; Ueno, Yoshitaka; Hosoda, Yasuo; Watanabe, Mamoru; Ishii, Hiromasa; Inoue, Takashi; Mukai, Makio.

In: Gastroenterological Endoscopy, Vol. 37, No. 1, 1995, p. 65-71.

Research output: Contribution to journalArticle

Hibi, T, Hayashi, A, Takaishi, H, Inoue, N, Ueno, Y, Hosoda, Y, Watanabe, M, Ishii, H, Inoue, T & Mukai, M 1995, 'A Case of Cowden's Disease Without Typical Skin Eruptions', Gastroenterological Endoscopy, vol. 37, no. 1, pp. 65-71. https://doi.org/10.11280/gee1973b.37.65
Hibi, Toshifumi ; Hayashi, Atsushi ; Takaishi, Hiromasa ; Inoue, Nagamu ; Ueno, Yoshitaka ; Hosoda, Yasuo ; Watanabe, Mamoru ; Ishii, Hiromasa ; Inoue, Takashi ; Mukai, Makio. / A Case of Cowden's Disease Without Typical Skin Eruptions. In: Gastroenterological Endoscopy. 1995 ; Vol. 37, No. 1. pp. 65-71.
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AU - Mukai, Makio

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