Abstract
We report a case of D-penicillamine induced herpetiform pemphigus. A 74-year-old female patient with rheumatoid arthritis had been receiving D-penicillamine therapy for 4 years and 8 months. After developing skin lesions, the patient was referred to our hospital. Physical examination revealed edematous erythema in annular patterns with blisters and vesicles on the trunk and extremities. A histological examination showed bullae and eosinophilic spongiosis in the epidermis. Direct and indirect immunofluorescence studies showed in vivo bound and circulating IgG anti-intercelluar space antibodies. An immunoblot analysis showed no specific positive reaction. Antibodies to both desmoglein (Dsg) 1 and Dsg 3 for initial serum were negative in ELISA. However, anti-Dsg 1 antibodies later became positive. The above mentioned laboratory and clinical data suggested a diagnosis of D-penicillamine induced herpetiform pemphigus in the present case.
| Original language | English |
|---|---|
| Pages (from-to) | 126-129 |
| Number of pages | 4 |
| Journal | Nishinihon Journal of Dermatology |
| Volume | 65 |
| Issue number | 2 |
| Publication status | Published - 2003 |
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ASJC Scopus subject areas
- Dermatology
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A case of D-penicillamine induced herpetiform pemphigus. / Abe, Toshifumi; Kouno, Michiyoshi; Yamamoto, Nobuhiro; Mori, Osamu; Hashimoto, Takashi; Amagai, Masayuki.
In: Nishinihon Journal of Dermatology, Vol. 65, No. 2, 2003, p. 126-129.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - A case of D-penicillamine induced herpetiform pemphigus
AU - Abe, Toshifumi
AU - Kouno, Michiyoshi
AU - Yamamoto, Nobuhiro
AU - Mori, Osamu
AU - Hashimoto, Takashi
AU - Amagai, Masayuki
PY - 2003
Y1 - 2003
N2 - We report a case of D-penicillamine induced herpetiform pemphigus. A 74-year-old female patient with rheumatoid arthritis had been receiving D-penicillamine therapy for 4 years and 8 months. After developing skin lesions, the patient was referred to our hospital. Physical examination revealed edematous erythema in annular patterns with blisters and vesicles on the trunk and extremities. A histological examination showed bullae and eosinophilic spongiosis in the epidermis. Direct and indirect immunofluorescence studies showed in vivo bound and circulating IgG anti-intercelluar space antibodies. An immunoblot analysis showed no specific positive reaction. Antibodies to both desmoglein (Dsg) 1 and Dsg 3 for initial serum were negative in ELISA. However, anti-Dsg 1 antibodies later became positive. The above mentioned laboratory and clinical data suggested a diagnosis of D-penicillamine induced herpetiform pemphigus in the present case.
AB - We report a case of D-penicillamine induced herpetiform pemphigus. A 74-year-old female patient with rheumatoid arthritis had been receiving D-penicillamine therapy for 4 years and 8 months. After developing skin lesions, the patient was referred to our hospital. Physical examination revealed edematous erythema in annular patterns with blisters and vesicles on the trunk and extremities. A histological examination showed bullae and eosinophilic spongiosis in the epidermis. Direct and indirect immunofluorescence studies showed in vivo bound and circulating IgG anti-intercelluar space antibodies. An immunoblot analysis showed no specific positive reaction. Antibodies to both desmoglein (Dsg) 1 and Dsg 3 for initial serum were negative in ELISA. However, anti-Dsg 1 antibodies later became positive. The above mentioned laboratory and clinical data suggested a diagnosis of D-penicillamine induced herpetiform pemphigus in the present case.
UR - http://www.scopus.com/inward/record.url?scp=0037273045&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0037273045&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:0037273045
VL - 65
SP - 126
EP - 129
JO - Nishinihon Journal of Dermatology
JF - Nishinihon Journal of Dermatology
SN - 0386-9784
IS - 2
ER -