A case of drug-induced hypersensitivity syndrome showing transient immunosuppression before viral reactivation during treatment for pemphigus foliaceus

H. Takahashi, M. Tanaka, A. Tanikawa, A. Toyohara, Y. Ogo, A. Morimoto, R. Harato, M. Kobayashi, M. Amagai

Research output: Contribution to journalArticle

15 Citations (Scopus)


Drug-induced hypersensitivity syndrome (DIHS) is one of the most severe drug adverse reactions, with characteristic biphasic symptoms. Reactivation of human herpesvirus-6 (HHV-6) is frequently observed, although the cause of DIHS is still unknown. A patient developed DIHS during treatment with diaminodiphenylsulphone for pemphigus foliaceus. The number of lymphocytes in his peripheral blood, and titres of serum total IgG and IgM and anti-desmoglein1 antibody transiently decreased just before reactivation of HHV-6, cytomegalovirus and Epstein-Barr virus. This observation suggests that transient suppression of both cellular and humoral immunity may trigger viral reactivation, which leads to the development of the second phase of DIHS.

Original languageEnglish
Pages (from-to)33-35
Number of pages3
JournalClinical and Experimental Dermatology
Issue number1
Publication statusPublished - 2006 Jan 1


ASJC Scopus subject areas

  • Dermatology

Cite this