TY - JOUR
T1 - A case of fulminant hepatitis B occurred in an asymptomatic
T2 - Hepatitis B virus carrier
AU - Ooishi, Tazuko
AU - Kumagai, Naoki
AU - Iwabuchi, Naoto
AU - Tsuchimoto, Kanji
AU - Kuramochi, Shigeru
AU - Tada, Shinichiro
AU - Tsunematsu, Satoshi
AU - Saito, Hidetsugu
AU - Ishii, Hiromasa
AU - Morizane, Toshio
PY - 1995/1/1
Y1 - 1995/1/1
N2 - A 54-year-old male was admitted to our hospital because of general malaise and jaundice. He had been an asymptomatic hepatitis B surface antigen (HBsAg) carrier and persistently positive for anti-hepatitis B e antigen (HBeAg) and negative for HBV DNA polymerase. His serological examination on admission revealed negative for HBeAg and positive for HVB DNA polymerase (2930 cpm) and the stop codon point mutation from G to A at uncleotide 83 in the precore region (mutant HBV83) was detected by MSSA method. Fluminant hepatitis developed, but the he gradually recovered with a support of intensive treatment, including a plasma exchange procedure. Afterward interferon treatment was performed, which finally normalized his liver function and a mutant HBV was disappeared from his serum. In this case, we could not approve any trigger for occurence of fluminant hepatitis associated with a HBV mutant.
AB - A 54-year-old male was admitted to our hospital because of general malaise and jaundice. He had been an asymptomatic hepatitis B surface antigen (HBsAg) carrier and persistently positive for anti-hepatitis B e antigen (HBeAg) and negative for HBV DNA polymerase. His serological examination on admission revealed negative for HBeAg and positive for HVB DNA polymerase (2930 cpm) and the stop codon point mutation from G to A at uncleotide 83 in the precore region (mutant HBV83) was detected by MSSA method. Fluminant hepatitis developed, but the he gradually recovered with a support of intensive treatment, including a plasma exchange procedure. Afterward interferon treatment was performed, which finally normalized his liver function and a mutant HBV was disappeared from his serum. In this case, we could not approve any trigger for occurence of fluminant hepatitis associated with a HBV mutant.
KW - asymptomatic carrier
KW - mutant HBV
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U2 - 10.2957/kanzo.36.706
DO - 10.2957/kanzo.36.706
M3 - Article
AN - SCOPUS:0029583017
SN - 0451-4203
VL - 36
SP - 706
EP - 711
JO - Acta Hepatologica Japonica
JF - Acta Hepatologica Japonica
IS - 12
ER -
