A case of fulminant hepatitis E treated with artificial liver support

Yoichi Fujiyama; Yoshiyuki Yamagishi; Masahiro Kikuchi; Kenichiro Shimoji; Shinzo Kato; Hiroshi Nagata; Hidetsugu Saito; Toshifumi Hibi; Syunji Mishiro

A case of fulminant hepatitis E treated with artificial liver support

Yoichi Fujiyama, Yoshiyuki Yamagishi, Masahiro Kikuchi, Kenichiro Shimoji, Shinzo Kato, Hiroshi Nagata, Hidetsugu Saito, Toshifumi Hibi, Syunji Mishiro

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Abstract

A 40-year-old man, who had suffered from general malaise and brown urine during his stay in China, was addmitted with remarkable jaundice and hepatocellular disorders soon after he returned to Japan. Because his coagulation test results worsened, he was transferred to our hospital. No evidence of hepatitis A-D virus infection, autoimmune hepatitis, or metabolic disorders was noticed. His prothrombin time was extended (18%), grade II encephalopathy appeared on the second hospital day, and fulminant hepatitis was diagnosed. Artificial liver support was introduced, and his hepatic coma and coagulation parameters gradually recovered. Genotype IV hepatitis E virus RNA was detected in his early phase sera and also both IgG and IgM type anti-hepatitis E virus antibodies were detected. Fulminant hepatitis E resulting from infection in China was diagnosed.

Original language	English
Pages (from-to)	219-225
Number of pages	7
Journal	Japanese Journal of Gastroenterology
Volume	104
Issue number	2
Publication status	Published - 2007 Feb

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Gastroenterology

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Fujiyama, Y., Yamagishi, Y., Kikuchi, M., Shimoji, K., Kato, S., Nagata, H., Saito, H., Hibi, T., & Mishiro, S. (2007). A case of fulminant hepatitis E treated with artificial liver support. Japanese Journal of Gastroenterology, 104(2), 219-225.

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abstract = "A 40-year-old man, who had suffered from general malaise and brown urine during his stay in China, was addmitted with remarkable jaundice and hepatocellular disorders soon after he returned to Japan. Because his coagulation test results worsened, he was transferred to our hospital. No evidence of hepatitis A-D virus infection, autoimmune hepatitis, or metabolic disorders was noticed. His prothrombin time was extended (18%), grade II encephalopathy appeared on the second hospital day, and fulminant hepatitis was diagnosed. Artificial liver support was introduced, and his hepatic coma and coagulation parameters gradually recovered. Genotype IV hepatitis E virus RNA was detected in his early phase sera and also both IgG and IgM type anti-hepatitis E virus antibodies were detected. Fulminant hepatitis E resulting from infection in China was diagnosed.",

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AU - Fujiyama, Yoichi

AU - Yamagishi, Yoshiyuki

AU - Kikuchi, Masahiro

AU - Shimoji, Kenichiro

AU - Kato, Shinzo

AU - Nagata, Hiroshi

AU - Saito, Hidetsugu

AU - Hibi, Toshifumi

AU - Mishiro, Syunji

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N2 - A 40-year-old man, who had suffered from general malaise and brown urine during his stay in China, was addmitted with remarkable jaundice and hepatocellular disorders soon after he returned to Japan. Because his coagulation test results worsened, he was transferred to our hospital. No evidence of hepatitis A-D virus infection, autoimmune hepatitis, or metabolic disorders was noticed. His prothrombin time was extended (18%), grade II encephalopathy appeared on the second hospital day, and fulminant hepatitis was diagnosed. Artificial liver support was introduced, and his hepatic coma and coagulation parameters gradually recovered. Genotype IV hepatitis E virus RNA was detected in his early phase sera and also both IgG and IgM type anti-hepatitis E virus antibodies were detected. Fulminant hepatitis E resulting from infection in China was diagnosed.

AB - A 40-year-old man, who had suffered from general malaise and brown urine during his stay in China, was addmitted with remarkable jaundice and hepatocellular disorders soon after he returned to Japan. Because his coagulation test results worsened, he was transferred to our hospital. No evidence of hepatitis A-D virus infection, autoimmune hepatitis, or metabolic disorders was noticed. His prothrombin time was extended (18%), grade II encephalopathy appeared on the second hospital day, and fulminant hepatitis was diagnosed. Artificial liver support was introduced, and his hepatic coma and coagulation parameters gradually recovered. Genotype IV hepatitis E virus RNA was detected in his early phase sera and also both IgG and IgM type anti-hepatitis E virus antibodies were detected. Fulminant hepatitis E resulting from infection in China was diagnosed.

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A case of fulminant hepatitis E treated with artificial liver support

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