A case of gastric adenocarcinoma of fundic gland type resected by combination of laparoscopic and endoscopic approaches to neoplasia with non-exposure technique (CLEAN-NET)

Motohiko Kato, Toshio Uraoka, Yoh Isobe, Keiichiro Abe, Tetsu Hirata, Yoshiaki Takada, Michiko Wada, Yusaku Takatori, Kaoru Takabayashi, Yoichi Fujiyama, Kousuke Sekiya, Yoshiki Kawaguchi, Aoi Sukeda, Junichi Shiraishi

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

A male in his eighties attended our hospital for further evaluation of gastric cancer. A gastroscopy revealed a whitish flat elevated lesion (Paris, 0-IIa) of 15 mm in diameter on the greater curvature of the proximal fornix. The preoperative diagnosis was intra-mucosal differentiated gastric cancer, and a novel therapeutic approach, combination of laparoscopic and endoscopic approaches to neoplasia with non-exposure technique (CLEAN-NET) was applied and the lesion was resected in a single piece without any complications. Histopathological findings revealed atypical glandular epithelium proliferated in the mucosa and shallow layer (300 μm) of submucosa. These cells stained positive for pepsinogen-I and the final diagnosis was gastric cancer of fundic gland type (GAFT). There was no lymph–vascular involvement and free horizontal and vertical margins were confirmed. CLEAN-NET could be a therapeutic option for GAFT at low risk of lymph node metastasis because it prevents excess wall defect and exposure of cancer cells into the peritoneal cavity.

Original languageEnglish
Pages (from-to)393-399
Number of pages7
JournalClinical Journal of Gastroenterology
Volume8
Issue number6
DOIs
Publication statusPublished - 2015 Dec 1
Externally publishedYes

Fingerprint

Stomach Neoplasms
Stomach
Adenocarcinoma
Pepsinogen A
Gastroscopy
Neoplasms
Peritoneal Cavity
Paris
Mucous Membrane
Epithelium
Lymph Nodes
Neoplasm Metastasis
Therapeutics

Keywords

  • CLEAN-NET
  • Full-thickness resection
  • Fundic gland type
  • Gastric cancer
  • LECS

ASJC Scopus subject areas

  • Gastroenterology

Cite this

A case of gastric adenocarcinoma of fundic gland type resected by combination of laparoscopic and endoscopic approaches to neoplasia with non-exposure technique (CLEAN-NET). / Kato, Motohiko; Uraoka, Toshio; Isobe, Yoh; Abe, Keiichiro; Hirata, Tetsu; Takada, Yoshiaki; Wada, Michiko; Takatori, Yusaku; Takabayashi, Kaoru; Fujiyama, Yoichi; Sekiya, Kousuke; Kawaguchi, Yoshiki; Sukeda, Aoi; Shiraishi, Junichi.

In: Clinical Journal of Gastroenterology, Vol. 8, No. 6, 01.12.2015, p. 393-399.

Research output: Contribution to journalArticle

Kato, Motohiko ; Uraoka, Toshio ; Isobe, Yoh ; Abe, Keiichiro ; Hirata, Tetsu ; Takada, Yoshiaki ; Wada, Michiko ; Takatori, Yusaku ; Takabayashi, Kaoru ; Fujiyama, Yoichi ; Sekiya, Kousuke ; Kawaguchi, Yoshiki ; Sukeda, Aoi ; Shiraishi, Junichi. / A case of gastric adenocarcinoma of fundic gland type resected by combination of laparoscopic and endoscopic approaches to neoplasia with non-exposure technique (CLEAN-NET). In: Clinical Journal of Gastroenterology. 2015 ; Vol. 8, No. 6. pp. 393-399.
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