A case of gastric cancer presenting with obstructive jaundice and responding to biweekly CPT-11 and CDDP combination administration

Toshiro Iizuka, Yoshio Hoshihara, Osamu Hoteya, Takashi Yamamoto, Naohisa Yahagi, Harushi Udagawa

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

A 74-year-old man was suffering from Borrmann type 2 advanced gastric cancer with abdominal lymph node metastases and multiple lung metastases. He started to undergo outpatient treatment with oral administration of TS-1. But pyloric stenosis was found after 6 courses of TS-1 chemotherapy, so he underwent palliative distal gastrectomy. TS-1 chemotherapy was continued afterwards, however obstructive jaundice was found. So combination chemotherapy of CPT-11 60 mg/m(2)and CDDP 30 mg/m(2)biweekly was selected as a second-line therapy after PTCD. As no side effects were found, he could be treated on an outpatient basis by CPT-11 60 mg/body and CDDP 30 mg/body biweekly. Four months has passed since the palliative operation, and the PTCD tube was successfully removed. The abdominal lymph nodes had decreased in size and the patient has maintained good QOL. Thus, combination CPT-11 and CDDP therapy could well be a new candidate for a second-line chemotherapy in outpatients.

Original languageEnglish
Pages (from-to)659-661
Number of pages3
JournalGan to kagaku ryoho. Cancer & chemotherapy.
Volume33
Issue number5
Publication statusPublished - 2006 May
Externally publishedYes

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irinotecan
Obstructive Jaundice
Stomach Neoplasms
Outpatients
Drug Therapy
Lymph Nodes
Pyloric Stenosis
Neoplasm Metastasis
Gastrectomy
Combination Drug Therapy
Oral Administration
Therapeutics
Lung
titanium silicide

ASJC Scopus subject areas

  • Cancer Research
  • Pharmacology

Cite this

A case of gastric cancer presenting with obstructive jaundice and responding to biweekly CPT-11 and CDDP combination administration. / Iizuka, Toshiro; Hoshihara, Yoshio; Hoteya, Osamu; Yamamoto, Takashi; Yahagi, Naohisa; Udagawa, Harushi.

In: Gan to kagaku ryoho. Cancer & chemotherapy., Vol. 33, No. 5, 05.2006, p. 659-661.

Research output: Contribution to journalArticle

Iizuka, Toshiro ; Hoshihara, Yoshio ; Hoteya, Osamu ; Yamamoto, Takashi ; Yahagi, Naohisa ; Udagawa, Harushi. / A case of gastric cancer presenting with obstructive jaundice and responding to biweekly CPT-11 and CDDP combination administration. In: Gan to kagaku ryoho. Cancer & chemotherapy. 2006 ; Vol. 33, No. 5. pp. 659-661.
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