A Case of herpetiform pemphigus associated with autoimmune hemolytic anemia: Detection of autoantibodies against multiple epidermal antigens

K. Shimizu, T. Hashimoto, N. Wang, K. Watanabe, Y. Ohata, A. Kikuchi, M. Amagai, T. Nisliikawa

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

We report a case who was clinically and histopathologically diagnosed as herpetiform pemphigus (HP) and associated with autoimmune hemolytic anemia (AIHA). However, immunofluorescence studies demonstrated concurrent anti-cell-surface and anti-basement-membrane-zone antibodies in the patient’s serum. Immunochemical studies showed that the patient’s serum reacted with both the pemphigus foliaceus antigen and the two bullous pemphigoid antigens. Subsequently, the patient developed AIHA. Both anemia and skin lesions were successfully treated with oral prednisolone. We believe that this is the first case with HP in association with AIHA. The presence of autoantibodies against multiple antigens suggests an abnormal immunologic tolerance in the antibody production system in this patient.

Original languageEnglish
Pages (from-to)179-182
Number of pages4
JournalDermatology
Volume192
Issue number2
DOIs
Publication statusPublished - 1996 Jan

Keywords

  • Autoantigen
  • Autoimmune hemolytic anemia
  • Bullous pemphigoid
  • Herpetiform pemphigus

ASJC Scopus subject areas

  • Dermatology

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