A case of herpetiform pemphigus associated with autoimmune hemolytic anemia: Detection of autoantibodies against multiple epidermal antigens

K. Shimizu, T. Hashimoto, N. Wang, K. Watanabe, Y. Ohata, A. Kikuchi, Masayuki Amagai, T. Nishikawa

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

We report a case who was clinically and histopathologically diagnosed as herpetiform pemphigus (HP) and associated with autoimmune hemolytic anemia (AIHA). However, immunofluorescence studies demonstrated concurrent anti-cell-surface and anti-basement-membrane-zone antibodies in the patient's serum. Immunochemical studies showed that the patient's serum reacted with both the pemphigus foliaceus antigen and the two bullous pemphigoid antigens. Subsequently, the patient developed AIHA. Both anemia and skin lesions were successfully treated with oral prednisolone. We believe that this is the first case with HP in association with AIHA. The presence of autoantibodies against multiple antigens suggests an abnormal immunologic tolerance in the antibody production system in this patient.

Original languageEnglish
Pages (from-to)179-182
Number of pages4
JournalDermatology
Volume192
Issue number2
Publication statusPublished - 1996

Fingerprint

Autoimmune Hemolytic Anemia
Pemphigus
Autoantibodies
Antigens
Desmoglein 1
Bullous Pemphigoid
Prednisolone
Serum
Basement Membrane
Antibody Formation
Fluorescent Antibody Technique
Anemia
Cohort Studies
Skin
Antibodies

Keywords

  • Autoantigen
  • Autoimmune hemolytic anemia
  • Bullous pemphigoid
  • Herpetiform pemphigus

ASJC Scopus subject areas

  • Dermatology

Cite this

Shimizu, K., Hashimoto, T., Wang, N., Watanabe, K., Ohata, Y., Kikuchi, A., ... Nishikawa, T. (1996). A case of herpetiform pemphigus associated with autoimmune hemolytic anemia: Detection of autoantibodies against multiple epidermal antigens. Dermatology, 192(2), 179-182.

A case of herpetiform pemphigus associated with autoimmune hemolytic anemia : Detection of autoantibodies against multiple epidermal antigens. / Shimizu, K.; Hashimoto, T.; Wang, N.; Watanabe, K.; Ohata, Y.; Kikuchi, A.; Amagai, Masayuki; Nishikawa, T.

In: Dermatology, Vol. 192, No. 2, 1996, p. 179-182.

Research output: Contribution to journalArticle

Shimizu, K, Hashimoto, T, Wang, N, Watanabe, K, Ohata, Y, Kikuchi, A, Amagai, M & Nishikawa, T 1996, 'A case of herpetiform pemphigus associated with autoimmune hemolytic anemia: Detection of autoantibodies against multiple epidermal antigens', Dermatology, vol. 192, no. 2, pp. 179-182.
Shimizu, K. ; Hashimoto, T. ; Wang, N. ; Watanabe, K. ; Ohata, Y. ; Kikuchi, A. ; Amagai, Masayuki ; Nishikawa, T. / A case of herpetiform pemphigus associated with autoimmune hemolytic anemia : Detection of autoantibodies against multiple epidermal antigens. In: Dermatology. 1996 ; Vol. 192, No. 2. pp. 179-182.
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