A case of idiopathic pulmonary upper lobe fibrosis complicated by invasive pulmonary aspergillosis

Satoshi Fuke; Tomoko Betsuyaku; Satoshi Oizumi; Yasuyuki Nasuhara; Hiroshi Saito; Etsuro Yamaguchi; Masaharu Nishimura

A case of idiopathic pulmonary upper lobe fibrosis complicated by invasive pulmonary aspergillosis

Satoshi Fuke, Tomoko Betsuyaku, Satoshi Oizumi, Yasuyuki Nasuhara, Hiroshi Saito, Etsuro Yamaguchi, Masaharu Nishimura

Research output: Contribution to journal › Article › peer-review

Abstract

A 72-year-old man with idiopathic pulmonary upper lobe fibrosis who had been followed for a year developed a high fever and yellow sputum in July 2001. Chest radiography and chest computed tomography (CT) showed a rapidly enlarging cavity with an internal mass and infiltration in the left upper lung field. Pulmonary aspergillosis was diagnosed by examination of bronchoalveolar lavage fluid (BALF). Administration of itraconazole improved his condition. The concentrations of surfactant proteins A (SP-A) and D (SP-D) in serum and in BALF were decreased during the clinical course. It is known that SP-A and SP-D are critical factors for host defense against aspergillus. The lowering of SP-A and SP-D in the serum and BALF seemed to reflect destructive changes of lung structure and impaired innate lung immunity that could to lead invasive pulmonary aspergillosis.

Original language	English
Pages (from-to)	196-201
Number of pages	6
Journal	Nihon Kokyūki Gakkai zasshi = the journal of the Japanese Respiratory Society
Volume	41
Issue number	3
Publication status	Published - 2003 Mar
Externally published	Yes

ASJC Scopus subject areas

Medicine(all)

Cite this

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title = "A case of idiopathic pulmonary upper lobe fibrosis complicated by invasive pulmonary aspergillosis",

abstract = "A 72-year-old man with idiopathic pulmonary upper lobe fibrosis who had been followed for a year developed a high fever and yellow sputum in July 2001. Chest radiography and chest computed tomography (CT) showed a rapidly enlarging cavity with an internal mass and infiltration in the left upper lung field. Pulmonary aspergillosis was diagnosed by examination of bronchoalveolar lavage fluid (BALF). Administration of itraconazole improved his condition. The concentrations of surfactant proteins A (SP-A) and D (SP-D) in serum and in BALF were decreased during the clinical course. It is known that SP-A and SP-D are critical factors for host defense against aspergillus. The lowering of SP-A and SP-D in the serum and BALF seemed to reflect destructive changes of lung structure and impaired innate lung immunity that could to lead invasive pulmonary aspergillosis.",

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T1 - A case of idiopathic pulmonary upper lobe fibrosis complicated by invasive pulmonary aspergillosis

AU - Fuke, Satoshi

AU - Betsuyaku, Tomoko

AU - Oizumi, Satoshi

AU - Nasuhara, Yasuyuki

AU - Saito, Hiroshi

AU - Yamaguchi, Etsuro

AU - Nishimura, Masaharu

PY - 2003/3

Y1 - 2003/3

N2 - A 72-year-old man with idiopathic pulmonary upper lobe fibrosis who had been followed for a year developed a high fever and yellow sputum in July 2001. Chest radiography and chest computed tomography (CT) showed a rapidly enlarging cavity with an internal mass and infiltration in the left upper lung field. Pulmonary aspergillosis was diagnosed by examination of bronchoalveolar lavage fluid (BALF). Administration of itraconazole improved his condition. The concentrations of surfactant proteins A (SP-A) and D (SP-D) in serum and in BALF were decreased during the clinical course. It is known that SP-A and SP-D are critical factors for host defense against aspergillus. The lowering of SP-A and SP-D in the serum and BALF seemed to reflect destructive changes of lung structure and impaired innate lung immunity that could to lead invasive pulmonary aspergillosis.

AB - A 72-year-old man with idiopathic pulmonary upper lobe fibrosis who had been followed for a year developed a high fever and yellow sputum in July 2001. Chest radiography and chest computed tomography (CT) showed a rapidly enlarging cavity with an internal mass and infiltration in the left upper lung field. Pulmonary aspergillosis was diagnosed by examination of bronchoalveolar lavage fluid (BALF). Administration of itraconazole improved his condition. The concentrations of surfactant proteins A (SP-A) and D (SP-D) in serum and in BALF were decreased during the clinical course. It is known that SP-A and SP-D are critical factors for host defense against aspergillus. The lowering of SP-A and SP-D in the serum and BALF seemed to reflect destructive changes of lung structure and impaired innate lung immunity that could to lead invasive pulmonary aspergillosis.

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A case of idiopathic pulmonary upper lobe fibrosis complicated by invasive pulmonary aspergillosis

Abstract

ASJC Scopus subject areas

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