A case of intrahepatic cholangiocarcinoma effectively treated by hepatic arterial infusion chemotherapy

Toshihiro Nishizawa, Hajime Higuchi, Hiromasa Takaishi, Hideko Iizuka, Motoko Izumiya, Yoshiyuki Yamagishi, Tadakazu Hisamatsu, Hidekazu Suzuki, Tatsuhiro Masaoka, Eisuke Iwasaki, Hiroshi Nagata, Toshifumi Hibi

Research output: Contribution to journalArticle

Abstract

The patient was a 50-year-old woman who suffered from gastric discomfort. She was first diagnosed as intrahepatic cholangiocarcinoma with hepatic, paraaortic lymphnodal and bone metastasis. Initial systemic chemotherapy using gemcitabine (GEM) and 5-FU failed to control the disease activity. Then she was given GEM and cisplatin (CDDP) combination chemotherapy. The response was assessed as stable disease (SD), but grade 4 leukopenia was seen. Then systemic therapy using GEM, and hepatic arterial infusion therapy with CDDP, l-leucovorin and 5-FU were continued biweekly. Partial response (PR) was achieved six months later, and her disease status was maintained as SD. This hepatic arterial infusion chemotherapy would be safe and feasible as therapy for inoperable intrahepatic cholangiocarcinoma.

Original languageEnglish
Pages (from-to)1657-1659
Number of pages3
JournalGan to kagaku ryoho. Cancer & chemotherapy
Volume33
Issue number11
Publication statusPublished - 2006 Nov

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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