A case of intrahepatic cholangiocellular carcinoma due to thorotrast deposition, well-controlled by radiofrequency ablation therapy

Nobuhito Taniki, Nobuhiro Nakamoto, Aya Yoshida, Po Sung Chu, Akihiko Ikura, Karin Yamataka, Rei Morikawa, Shunsuke Shiba, Akihiro Yamaguchi, Shingo Usui, Keisuke Ojiro, Hirotoshi Ebinuma, Hidetsugu Saito, Naoto Kubota, Yohei Masugi, Michiie Sakamto, Takanori Kanai

Research output: Contribution to journalArticle

Abstract

An 87-year-old man with an enlarged hepatic tumor was referred to our institute by a medical examination center. He had been diagnosed with a malignant liver tumor through several contrast imaging studies. Because of the patient’s age, the underlying disease, and the absence of bile duct invasion on imaging, radiofrequency ablation (RFA) was selected as a treatment option. A histological examination during the RFA procedure revealed the tumor to be a cholangiocellular carcinoma. In addition, the deposition of Thorotrast, a contrast agent used in the 1930s to 1950s, was suspected in the background liver collected simultaneously. Radiofrequency ablation was performed twice for recurrent lesions, and the tumor was controlled for roughly 3 years following the initial treatment. A case of intrahepatic cholangiocellular carcinoma due to Thorotrast deposition was observed and successfully controlled by RFA. Since intrahepatic cholangiocellular carcinoma from Thorotrast deposition occurs multicentrically and intrahepatically, RFA and other local therapies may present effective options for older patients with cholangiocarcinoma who are at a higher risk of surgical resection intolerance.

Original languageEnglish
Pages (from-to)262-269
Number of pages8
JournalActa Hepatologica Japonica
Volume61
Issue number5
DOIs
Publication statusPublished - 2020 Jan 1

Keywords

  • Cholangiocarcinoma
  • Internal irradiation
  • Multicentric carcinogenesis
  • Radiofrequency ablation therapy
  • Thorotrast

ASJC Scopus subject areas

  • Hepatology

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  • Cite this

    Taniki, N., Nakamoto, N., Yoshida, A., Chu, P. S., Ikura, A., Yamataka, K., Morikawa, R., Shiba, S., Yamaguchi, A., Usui, S., Ojiro, K., Ebinuma, H., Saito, H., Kubota, N., Masugi, Y., Sakamto, M., & Kanai, T. (2020). A case of intrahepatic cholangiocellular carcinoma due to thorotrast deposition, well-controlled by radiofrequency ablation therapy. Acta Hepatologica Japonica, 61(5), 262-269. https://doi.org/10.2957/kanzo.61.262