A case of membranous nephropathy with primary biliary cirrhosis and cyclosporine-induced remission

Yusuke Sakamaki, Matsuhiko Hayashi, Shu Wakino, Seiichi Fukuda, Kounosuke Konishi, Akinori Hashiguchi, Koichi Hayashi, Hiroshi Itoh

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

We report a case of membranous nephropathy with primary biliary cirrhosis (PBC). A 76-year-old Japanese man had been treated for PBC and was referred to our department because of acute severe proteinuria (10 g/day). Renal biopsy was performed and was compatible with a diagnosis of membranous nephropathy. The patient was treated with cyclosporine A (CsA; Neoral®), which was followed by normalization of liver function and partial remission of proteinuria (0.68 g/day) within six months without any significant side effects. This case suggests that CsA monotherapy is effective for the treatment of both liver dysfunction and membranous nephropathy associated with PBC.

Original languageEnglish
Pages (from-to)233-238
Number of pages6
JournalInternal Medicine
Volume50
Issue number3
DOIs
Publication statusPublished - 2011

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Membranous Glomerulonephritis
Biliary Liver Cirrhosis
Cyclosporine
Proteinuria
Liver Diseases
Kidney
Biopsy
Liver
Therapeutics

Keywords

  • Cyclosporine
  • Membranous nephropathy
  • Nephrotic syndrome
  • Primary biliary cirrhosis

ASJC Scopus subject areas

  • Internal Medicine

Cite this

A case of membranous nephropathy with primary biliary cirrhosis and cyclosporine-induced remission. / Sakamaki, Yusuke; Hayashi, Matsuhiko; Wakino, Shu; Fukuda, Seiichi; Konishi, Kounosuke; Hashiguchi, Akinori; Hayashi, Koichi; Itoh, Hiroshi.

In: Internal Medicine, Vol. 50, No. 3, 2011, p. 233-238.

Research output: Contribution to journalArticle

Sakamaki, Yusuke ; Hayashi, Matsuhiko ; Wakino, Shu ; Fukuda, Seiichi ; Konishi, Kounosuke ; Hashiguchi, Akinori ; Hayashi, Koichi ; Itoh, Hiroshi. / A case of membranous nephropathy with primary biliary cirrhosis and cyclosporine-induced remission. In: Internal Medicine. 2011 ; Vol. 50, No. 3. pp. 233-238.
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