A case of PBC-AIH overlap syndrome deteriorated autoimmune hepatitis during the administration of ursodeoxycholic acid

Kohichi Takada; Junji Kato; Kunihiro Takanashi; Yutaka Kawano; Toshinori Okuda; Tuyoshi Hayashi; Hirotoshi Ishiwatari; Sho Takahashi; Koji Miyanishi; Tsutomu Sato; Yasushi Sato; Rishu Takimoto; Masayoshi Kobune; Tetsuji Takayama; Minoru Takahashi; Aya Sasaki; Yoshiro Niitsu

doi:10.2957/kanzo.47.304

A case of PBC-AIH overlap syndrome deteriorated autoimmune hepatitis during the administration of ursodeoxycholic acid

Kohichi Takada, Junji Kato, Kunihiro Takanashi, Yutaka Kawano, Toshinori Okuda, Tuyoshi Hayashi, Hirotoshi Ishiwatari, Sho Takahashi, Koji Miyanishi, Tsutomu Sato, Yasushi Sato, Rishu Takimoto, Masayoshi Kobune, Tetsuji Takayama, Minoru Takahashi, Aya Sasaki, Yoshiro Niitsu

Research output: Contribution to journal › Article › peer-review

Abstract

A 54-year-old woman diagnosed as PBC-AIH overlap syndrome had been treated with UDCA. She was admitted to our hospital due to acute exacerbation of serum transaminase levels on January, 2004. Serum IgG level was normal but liver biopsy showed worsened AIH. Human leukocyte antigen (HLA) DR4 was positive. According to the IAHG scoring system her score was 11 points, indicating probable AIH. The serum transaminase levels effectively decreased after administration of corticosteroid. It is suggested that HLA DR4-positive patients with PBC-AIH overlap syndrome may develop worsened AIH during UDCA treatment.

Original language	English
Pages (from-to)	304-309
Number of pages	6
Journal	Acta Hepatologica Japonica
Volume	47
Issue number	6
DOIs	https://doi.org/10.2957/kanzo.47.304
Publication status	Published - 2006
Externally published	Yes

ASJC Scopus subject areas

Hepatology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.2957/kanzo.47.304

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Takada, K., Kato, J., Takanashi, K., Kawano, Y., Okuda, T., Hayashi, T., Ishiwatari, H., Takahashi, S., Miyanishi, K., Sato, T., Sato, Y., Takimoto, R., Kobune, M., Takayama, T., Takahashi, M., Sasaki, A., & Niitsu, Y. (2006). A case of PBC-AIH overlap syndrome deteriorated autoimmune hepatitis during the administration of ursodeoxycholic acid. Acta Hepatologica Japonica, 47(6), 304-309. https://doi.org/10.2957/kanzo.47.304

Takada, K, Kato, J, Takanashi, K, Kawano, Y, Okuda, T, Hayashi, T, Ishiwatari, H, Takahashi, S, Miyanishi, K, Sato, T, Sato, Y, Takimoto, R, Kobune, M, Takayama, T, Takahashi, M, Sasaki, A & Niitsu, Y 2006, 'A case of PBC-AIH overlap syndrome deteriorated autoimmune hepatitis during the administration of ursodeoxycholic acid', Acta Hepatologica Japonica, vol. 47, no. 6, pp. 304-309. https://doi.org/10.2957/kanzo.47.304

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title = "A case of PBC-AIH overlap syndrome deteriorated autoimmune hepatitis during the administration of ursodeoxycholic acid",

abstract = "A 54-year-old woman diagnosed as PBC-AIH overlap syndrome had been treated with UDCA. She was admitted to our hospital due to acute exacerbation of serum transaminase levels on January, 2004. Serum IgG level was normal but liver biopsy showed worsened AIH. Human leukocyte antigen (HLA) DR4 was positive. According to the IAHG scoring system her score was 11 points, indicating probable AIH. The serum transaminase levels effectively decreased after administration of corticosteroid. It is suggested that HLA DR4-positive patients with PBC-AIH overlap syndrome may develop worsened AIH during UDCA treatment.",

author = "Kohichi Takada and Junji Kato and Kunihiro Takanashi and Yutaka Kawano and Toshinori Okuda and Tuyoshi Hayashi and Hirotoshi Ishiwatari and Sho Takahashi and Koji Miyanishi and Tsutomu Sato and Yasushi Sato and Rishu Takimoto and Masayoshi Kobune and Tetsuji Takayama and Minoru Takahashi and Aya Sasaki and Yoshiro Niitsu",

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doi = "10.2957/kanzo.47.304",

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T1 - A case of PBC-AIH overlap syndrome deteriorated autoimmune hepatitis during the administration of ursodeoxycholic acid

AU - Takada, Kohichi

AU - Kato, Junji

AU - Takanashi, Kunihiro

AU - Kawano, Yutaka

AU - Okuda, Toshinori

AU - Hayashi, Tuyoshi

AU - Ishiwatari, Hirotoshi

AU - Takahashi, Sho

AU - Miyanishi, Koji

AU - Sato, Tsutomu

AU - Sato, Yasushi

AU - Takimoto, Rishu

AU - Kobune, Masayoshi

AU - Takayama, Tetsuji

AU - Takahashi, Minoru

AU - Sasaki, Aya

AU - Niitsu, Yoshiro

PY - 2006

Y1 - 2006

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AB - A 54-year-old woman diagnosed as PBC-AIH overlap syndrome had been treated with UDCA. She was admitted to our hospital due to acute exacerbation of serum transaminase levels on January, 2004. Serum IgG level was normal but liver biopsy showed worsened AIH. Human leukocyte antigen (HLA) DR4 was positive. According to the IAHG scoring system her score was 11 points, indicating probable AIH. The serum transaminase levels effectively decreased after administration of corticosteroid. It is suggested that HLA DR4-positive patients with PBC-AIH overlap syndrome may develop worsened AIH during UDCA treatment.

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A case of PBC-AIH overlap syndrome deteriorated autoimmune hepatitis during the administration of ursodeoxycholic acid

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