A case of pemphigus vulgaris showing reactivity with pemphigus antigens (Dsg1 and Dsg3) and desmocolliins

T. Hashimoto, M. Amagai, K. Watanabe, M. Dmochowski, M. A.J. Chidgey, K. K.M. Yue, D. R. Garrod, T. Nishikawa

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

Both pemphigus vulgaris antigen (PVA; Dsg3) and pemphigus foliaceus antigen (PFA; Dsg1) are members of the desmoglein subfamily of the cadherin supergene family. Another desmosomal cadherin, desmocollin, is occasionally recognized by certain pemphigus sera. We present a 38-year-old Japanese male who showed clinically and histopathologically typical features of pemphigus vulgaris, whose sera reacted with all PVA, PFA, and desmocollins using immunoblotting of both human epidermis and bovine snout epidermis. Studies using domain-specific fusion proteins of PFA and PVA suggested that this patient's serum reacted with the intracellular domain of PFA and the extracellular domain of PVA, the latter of which seems to be responsible for initiating the skin lesion. The patient's serum showed reactivity with human desmocollin and was shown to react with bovine Dsc2 fusion protein, further suggesting the significance of anti-desmocollin autoantibodies in pemphigus. These results indicate that certain pemphigus cases may produce antibodies against multiple antigen molecules, although the complex mechanism of the production of autoantibodies remains to be elucidated.

Original languageEnglish
Pages (from-to)541-544
Number of pages4
JournalJournal of Investigative Dermatology
Volume104
Issue number4
DOIs
Publication statusPublished - 1995 Jan 1

    Fingerprint

Keywords

  • Cadherin
  • Desmoglein
  • Pemphigus foliaceus

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Dermatology
  • Cell Biology

Cite this

Hashimoto, T., Amagai, M., Watanabe, K., Dmochowski, M., Chidgey, M. A. J., Yue, K. K. M., Garrod, D. R., & Nishikawa, T. (1995). A case of pemphigus vulgaris showing reactivity with pemphigus antigens (Dsg1 and Dsg3) and desmocolliins. Journal of Investigative Dermatology, 104(4), 541-544. https://doi.org/10.1111/1523-1747.ep12606050