A case of persistent elevation of serum glutamic oxaloacetic transaminase due to enzyme-immunoglobulin complex formation

Shinzo Kato, Hiromasa Ishii, Toshikazu Takagi, Yoshiaki Asaba, Makoto Ichijo, Masaharu Tsuchiya, Shojiro Kano, Mieko Saga, Kouji Horii

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

A 43 year-old male, who has no complaints, was admitted for the evaluation of the persistent elevation of serum Glutamic Oxaloacetic Transaminase (GOT) activity. He showed slight hepatomegaly, but no other abnormal findings in physical examination. The abnormal laboratory finding was found only in serum GOT level, and other tests including ECG, EMG, ICG-15 min, liver scintigram and histology of biopsied liver were normal. By using electrophoresis and immunofixation technique, we found that serum GOT was bound to immunoglobulin IgG (A) and formed enzyme-immunogolbulin complex. Elevation of serum GOT seemed to be derived from the delayed disappearance rate of GOT from the blood, and not from the increase in release of GOT from the tissues.

Original languageEnglish
Pages (from-to)664-668
Number of pages5
JournalActa Hepatologica Japonica
Volume24
Issue number6
DOIs
Publication statusPublished - 1983

Fingerprint

Aspartate Aminotransferases
Immunoglobulins
Enzymes
Hepatomegaly
Liver
Physical Examination
Electrophoresis
Histology
Electrocardiography
Immunoglobulin G

ASJC Scopus subject areas

  • Hepatology

Cite this

A case of persistent elevation of serum glutamic oxaloacetic transaminase due to enzyme-immunoglobulin complex formation. / Kato, Shinzo; Ishii, Hiromasa; Takagi, Toshikazu; Asaba, Yoshiaki; Ichijo, Makoto; Tsuchiya, Masaharu; Kano, Shojiro; Saga, Mieko; Horii, Kouji.

In: Acta Hepatologica Japonica, Vol. 24, No. 6, 1983, p. 664-668.

Research output: Contribution to journalArticle

Kato, S, Ishii, H, Takagi, T, Asaba, Y, Ichijo, M, Tsuchiya, M, Kano, S, Saga, M & Horii, K 1983, 'A case of persistent elevation of serum glutamic oxaloacetic transaminase due to enzyme-immunoglobulin complex formation', Acta Hepatologica Japonica, vol. 24, no. 6, pp. 664-668. https://doi.org/10.2957/kanzo.24.664
Kato, Shinzo ; Ishii, Hiromasa ; Takagi, Toshikazu ; Asaba, Yoshiaki ; Ichijo, Makoto ; Tsuchiya, Masaharu ; Kano, Shojiro ; Saga, Mieko ; Horii, Kouji. / A case of persistent elevation of serum glutamic oxaloacetic transaminase due to enzyme-immunoglobulin complex formation. In: Acta Hepatologica Japonica. 1983 ; Vol. 24, No. 6. pp. 664-668.
@article{943600151bab42f3acd88076e6a45c91,
title = "A case of persistent elevation of serum glutamic oxaloacetic transaminase due to enzyme-immunoglobulin complex formation",
abstract = "A 43 year-old male, who has no complaints, was admitted for the evaluation of the persistent elevation of serum Glutamic Oxaloacetic Transaminase (GOT) activity. He showed slight hepatomegaly, but no other abnormal findings in physical examination. The abnormal laboratory finding was found only in serum GOT level, and other tests including ECG, EMG, ICG-15 min, liver scintigram and histology of biopsied liver were normal. By using electrophoresis and immunofixation technique, we found that serum GOT was bound to immunoglobulin IgG (A) and formed enzyme-immunogolbulin complex. Elevation of serum GOT seemed to be derived from the delayed disappearance rate of GOT from the blood, and not from the increase in release of GOT from the tissues.",
author = "Shinzo Kato and Hiromasa Ishii and Toshikazu Takagi and Yoshiaki Asaba and Makoto Ichijo and Masaharu Tsuchiya and Shojiro Kano and Mieko Saga and Kouji Horii",
year = "1983",
doi = "10.2957/kanzo.24.664",
language = "English",
volume = "24",
pages = "664--668",
journal = "Acta Hepatologica Japonica",
issn = "0451-4203",
publisher = "Japan Society of Hepatology",
number = "6",

}

TY - JOUR

T1 - A case of persistent elevation of serum glutamic oxaloacetic transaminase due to enzyme-immunoglobulin complex formation

AU - Kato, Shinzo

AU - Ishii, Hiromasa

AU - Takagi, Toshikazu

AU - Asaba, Yoshiaki

AU - Ichijo, Makoto

AU - Tsuchiya, Masaharu

AU - Kano, Shojiro

AU - Saga, Mieko

AU - Horii, Kouji

PY - 1983

Y1 - 1983

N2 - A 43 year-old male, who has no complaints, was admitted for the evaluation of the persistent elevation of serum Glutamic Oxaloacetic Transaminase (GOT) activity. He showed slight hepatomegaly, but no other abnormal findings in physical examination. The abnormal laboratory finding was found only in serum GOT level, and other tests including ECG, EMG, ICG-15 min, liver scintigram and histology of biopsied liver were normal. By using electrophoresis and immunofixation technique, we found that serum GOT was bound to immunoglobulin IgG (A) and formed enzyme-immunogolbulin complex. Elevation of serum GOT seemed to be derived from the delayed disappearance rate of GOT from the blood, and not from the increase in release of GOT from the tissues.

AB - A 43 year-old male, who has no complaints, was admitted for the evaluation of the persistent elevation of serum Glutamic Oxaloacetic Transaminase (GOT) activity. He showed slight hepatomegaly, but no other abnormal findings in physical examination. The abnormal laboratory finding was found only in serum GOT level, and other tests including ECG, EMG, ICG-15 min, liver scintigram and histology of biopsied liver were normal. By using electrophoresis and immunofixation technique, we found that serum GOT was bound to immunoglobulin IgG (A) and formed enzyme-immunogolbulin complex. Elevation of serum GOT seemed to be derived from the delayed disappearance rate of GOT from the blood, and not from the increase in release of GOT from the tissues.

UR - http://www.scopus.com/inward/record.url?scp=84913041140&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84913041140&partnerID=8YFLogxK

U2 - 10.2957/kanzo.24.664

DO - 10.2957/kanzo.24.664

M3 - Article

AN - SCOPUS:84913041140

VL - 24

SP - 664

EP - 668

JO - Acta Hepatologica Japonica

JF - Acta Hepatologica Japonica

SN - 0451-4203

IS - 6

ER -