A case of primary gastric small cell carcinoma with a rare pattern of lymph node metastasis

Hiroya Takeuchi, Ken Futamata, Arafumi Maeshima, Shigemichi Hirose, Atsushi Shimada, Yoshiki Kawaguchi, Jo Tokuyama, Koji Osumi, Shinya Kishi, Takashi Hojo, Shiei Kim, Norihito Wada, Takashi Oishi, Yoh Isobe, Shunji Ikeuchi, Kiyoshi Kubochi, Sumio Matsumoto

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

We report a very rare case of primary gastric small cell carcinoma (GSCC) that was accompanied with gastric tubular adenocarcinoma. A male in his 60s had an elevated tumor with a central ulceration in the middle stomach. The patient underwent a distal gastrectomy with lymph node dissection. The pathological examination showed two separated lesions of the stomach, which contained the components of primary GSCC and primary gastric tubular adenocarcinoma. Immunohistochemical (IHC) examination demonstrated that the tumor cells in the small cell carcinoma stained positive for synaptophysin, chromogranin A, and neural cell adhesion molecule (NCAM). GSCC cells and adenocarcinoma cells independently metastasized to each regional lymph node. Further studies on the biological behavior of individual tumors may allow the development of new treatment strategies for GSCC.

Original languageEnglish
Pages (from-to)99-104
Number of pages6
JournalInternational Journal of Gastrointestinal Cancer
Volume36
Issue number2
DOIs
Publication statusPublished - 2005 Oct
Externally publishedYes

Fingerprint

Small Cell Carcinoma
Stomach
Lymph Nodes
Neoplasm Metastasis
Adenocarcinoma
Neural Cell Adhesion Molecules
Chromogranin A
Neoplasms
Synaptophysin
Gastrectomy
Lymph Node Excision

Keywords

  • Adenocarcinoma
  • Lymph node metastasis
  • Small cell carcinoma
  • Stomach

ASJC Scopus subject areas

  • Gastroenterology
  • Endocrinology
  • Oncology

Cite this

Takeuchi, H., Futamata, K., Maeshima, A., Hirose, S., Shimada, A., Kawaguchi, Y., ... Matsumoto, S. (2005). A case of primary gastric small cell carcinoma with a rare pattern of lymph node metastasis. International Journal of Gastrointestinal Cancer, 36(2), 99-104. https://doi.org/10.1385/IJGC:36:2:99

A case of primary gastric small cell carcinoma with a rare pattern of lymph node metastasis. / Takeuchi, Hiroya; Futamata, Ken; Maeshima, Arafumi; Hirose, Shigemichi; Shimada, Atsushi; Kawaguchi, Yoshiki; Tokuyama, Jo; Osumi, Koji; Kishi, Shinya; Hojo, Takashi; Kim, Shiei; Wada, Norihito; Oishi, Takashi; Isobe, Yoh; Ikeuchi, Shunji; Kubochi, Kiyoshi; Matsumoto, Sumio.

In: International Journal of Gastrointestinal Cancer, Vol. 36, No. 2, 10.2005, p. 99-104.

Research output: Contribution to journalArticle

Takeuchi, H, Futamata, K, Maeshima, A, Hirose, S, Shimada, A, Kawaguchi, Y, Tokuyama, J, Osumi, K, Kishi, S, Hojo, T, Kim, S, Wada, N, Oishi, T, Isobe, Y, Ikeuchi, S, Kubochi, K & Matsumoto, S 2005, 'A case of primary gastric small cell carcinoma with a rare pattern of lymph node metastasis', International Journal of Gastrointestinal Cancer, vol. 36, no. 2, pp. 99-104. https://doi.org/10.1385/IJGC:36:2:99
Takeuchi, Hiroya ; Futamata, Ken ; Maeshima, Arafumi ; Hirose, Shigemichi ; Shimada, Atsushi ; Kawaguchi, Yoshiki ; Tokuyama, Jo ; Osumi, Koji ; Kishi, Shinya ; Hojo, Takashi ; Kim, Shiei ; Wada, Norihito ; Oishi, Takashi ; Isobe, Yoh ; Ikeuchi, Shunji ; Kubochi, Kiyoshi ; Matsumoto, Sumio. / A case of primary gastric small cell carcinoma with a rare pattern of lymph node metastasis. In: International Journal of Gastrointestinal Cancer. 2005 ; Vol. 36, No. 2. pp. 99-104.
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AB - We report a very rare case of primary gastric small cell carcinoma (GSCC) that was accompanied with gastric tubular adenocarcinoma. A male in his 60s had an elevated tumor with a central ulceration in the middle stomach. The patient underwent a distal gastrectomy with lymph node dissection. The pathological examination showed two separated lesions of the stomach, which contained the components of primary GSCC and primary gastric tubular adenocarcinoma. Immunohistochemical (IHC) examination demonstrated that the tumor cells in the small cell carcinoma stained positive for synaptophysin, chromogranin A, and neural cell adhesion molecule (NCAM). GSCC cells and adenocarcinoma cells independently metastasized to each regional lymph node. Further studies on the biological behavior of individual tumors may allow the development of new treatment strategies for GSCC.

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