A Case of Pulmonary Veno-Occlusive Disease Following Hepatic Veno-Occlusive Disease after Autologous Hematopoietic Stem Cell Transplantation for Neuroblastoma

Research output: Contribution to journalArticle

Abstract

Pulmonary veno-occlusive disease (PVOD) is an uncommon form of pulmonary hypertension that is usually difficult to diagnose and is refractory to conservative treatment. PVOD can occur in connection with high-dose chemotherapy or hematopoietic stem cell transplantation, similar to hepatic veno-occlusive disease (HVOD). Here, we present a case of neuroblastoma with PVOD following HVOD after high-dose chemotherapy that was resolved with conservative treatment. Respiratory symptoms or edema after HVOD may suggest PVOD, and prompt diagnosis on high-resolution computed tomography will result in a favorable prognosis.

Original languageEnglish
JournalJournal of Pediatric Hematology/Oncology
DOIs
Publication statusPublished - 2019 Jan 1

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Pulmonary Veno-Occlusive Disease
Hepatic Veno-Occlusive Disease
Hematopoietic Stem Cell Transplantation
Neuroblastoma
Drug Therapy
Pulmonary Hypertension
Edema
Tomography

Keywords

  • high resolution computed tomography
  • high-dose chemotherapy
  • pulmonary hypertension
  • transplantation
  • veno-occlusive disease

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Hematology
  • Oncology

Cite this

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title = "A Case of Pulmonary Veno-Occlusive Disease Following Hepatic Veno-Occlusive Disease after Autologous Hematopoietic Stem Cell Transplantation for Neuroblastoma",
abstract = "Pulmonary veno-occlusive disease (PVOD) is an uncommon form of pulmonary hypertension that is usually difficult to diagnose and is refractory to conservative treatment. PVOD can occur in connection with high-dose chemotherapy or hematopoietic stem cell transplantation, similar to hepatic veno-occlusive disease (HVOD). Here, we present a case of neuroblastoma with PVOD following HVOD after high-dose chemotherapy that was resolved with conservative treatment. Respiratory symptoms or edema after HVOD may suggest PVOD, and prompt diagnosis on high-resolution computed tomography will result in a favorable prognosis.",
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author = "Kyohei Isshiki and Haruko Shima and Fumito Yamazaki and Toshiki Takenouchi and Hiroyuki Shimada",
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AU - Shima, Haruko

AU - Yamazaki, Fumito

AU - Takenouchi, Toshiki

AU - Shimada, Hiroyuki

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N2 - Pulmonary veno-occlusive disease (PVOD) is an uncommon form of pulmonary hypertension that is usually difficult to diagnose and is refractory to conservative treatment. PVOD can occur in connection with high-dose chemotherapy or hematopoietic stem cell transplantation, similar to hepatic veno-occlusive disease (HVOD). Here, we present a case of neuroblastoma with PVOD following HVOD after high-dose chemotherapy that was resolved with conservative treatment. Respiratory symptoms or edema after HVOD may suggest PVOD, and prompt diagnosis on high-resolution computed tomography will result in a favorable prognosis.

AB - Pulmonary veno-occlusive disease (PVOD) is an uncommon form of pulmonary hypertension that is usually difficult to diagnose and is refractory to conservative treatment. PVOD can occur in connection with high-dose chemotherapy or hematopoietic stem cell transplantation, similar to hepatic veno-occlusive disease (HVOD). Here, we present a case of neuroblastoma with PVOD following HVOD after high-dose chemotherapy that was resolved with conservative treatment. Respiratory symptoms or edema after HVOD may suggest PVOD, and prompt diagnosis on high-resolution computed tomography will result in a favorable prognosis.

KW - high resolution computed tomography

KW - high-dose chemotherapy

KW - pulmonary hypertension

KW - transplantation

KW - veno-occlusive disease

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