A Case of Pulmonary Veno-Occlusive Disease Following Hepatic Veno-Occlusive Disease after Autologous Hematopoietic Stem Cell Transplantation for Neuroblastoma

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Abstract

Pulmonary veno-occlusive disease (PVOD) is an uncommon form of pulmonary hypertension that is usually difficult to diagnose and is refractory to conservative treatment. PVOD can occur in connection with high-dose chemotherapy or hematopoietic stem cell transplantation, similar to hepatic veno-occlusive disease (HVOD). Here, we present a case of neuroblastoma with PVOD following HVOD after high-dose chemotherapy that was resolved with conservative treatment. Respiratory symptoms or edema after HVOD may suggest PVOD, and prompt diagnosis on high-resolution computed tomography will result in a favorable prognosis.

Original languageEnglish
JournalJournal of Pediatric Hematology/Oncology
DOIs
Publication statusPublished - 2019 Jan 1

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Keywords

  • high resolution computed tomography
  • high-dose chemotherapy
  • pulmonary hypertension
  • transplantation
  • veno-occlusive disease

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Hematology
  • Oncology

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