A case of radiologically multicentric but genetically identical multiple glioblastomas

Jiro Akimoto, Hikaru Sasaki, Rei Haraoka, Nobuyuki Nakajima, Shinjiro Fukami, Michihiro Kohno

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Surgery was performed in a 65-year-old male patient with malignant gliomas at two locations in the left and right cerebral hemispheres that showed no apparent continuity in imaging studies. Slight differences in histopathological appearance were seen between the tumors, and multicentric malignant glioma was diagnosed. Detailed genetic examination showed both the left- and right-side tumors to be of the IDH-1 wild type with a p53 mutation at the same locus. Whole genome analysis by comparative genomic hybridization revealed many of the same mutations to be present in both tumors. The O6-methylguanine- methyltransferase promoter in both cases was unmethylated, and the genetic profiles of both showed them to be homologous tumors. They were therefore inferred to be multiple gliomas from the same clone. There have been occasional reports of multicentric gliomas classified by diagnostic imaging. This report discusses the need to examine tumor origin by genomic profiling.

Original languageEnglish
Pages (from-to)113-117
Number of pages5
JournalBrain tumor pathology
Volume31
Issue number2
DOIs
Publication statusPublished - 2014 Apr

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Keywords

  • Comparative genomic hybridization
  • Genomic profiling
  • IDH-1 mutation
  • MGMT promoter methylation
  • Multicentric glioma
  • p53 mutation

ASJC Scopus subject areas

  • Oncology
  • Clinical Neurology
  • Cancer Research

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