A case of severe cholestatic jaundice with hyperthyroidism successfully treated with methimazole

Hitoshi Ichikawa, Hirotoshi Ebinuma, Shinichirou Tada, Keisuke Ojiro, Yoshiyuki Yamagishi, Nobuhiro Tsukada, Emi Hongou, Osamu Funae, Rie Irie, Hidetsugu Saito, Toshifumi Hibi

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


Liver dysfunction is a common complication observed in patients with hyperthyroidism, however the dysfunction is always mild and obvious jaundice is rarely observed. We present the case of a 43-year-old man who suffered from hyperthyroidism complicated by severe jaundice. The jaundice likely occurred as a secondary consequence of cholestasis due to hyperthyroidism, since other causes such as drug-induced or autoimmune liver dysfunction were ruled out. Treatment with methimazole improved severe cholestatic jaundice in parallel with normalization of thyroid function. The mechanism of cholestasis as a secondary complication of hyperthyroidism has not been uncovered and there is no specific biochemical marker for cholestasis due to this hormonal disease at present. This case serves as a reminder that severe jaundice can be a manifestation of simple hyperthyroidism, and that administration of antithyroid drugs is an effective treatment for severe cholestatic jaundice in such cases.

Original languageEnglish
Pages (from-to)315-319
Number of pages5
JournalClinical journal of gastroenterology
Issue number4
Publication statusPublished - 2009 Aug


  • Cholestatis
  • Hyperthyroidism
  • Jaundice

ASJC Scopus subject areas

  • Gastroenterology


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