A case of severe cholestatic jaundice with hyperthyroidism successfully treated with methimazole

Hitoshi Ichikawa, Hirotoshi Ebinuma, Shinichirou Tada, Keisuke Ojiro, Yoshiyuki Yamagishi, Nobuhiro Tsukada, Emi Hongou, Osamu Funae, Rie Irie, Hidetsugu Saito, Toshifumi Hibi

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Liver dysfunction is a common complication observed in patients with hyperthyroidism, however the dysfunction is always mild and obvious jaundice is rarely observed. We present the case of a 43-year-old man who suffered from hyperthyroidism complicated by severe jaundice. The jaundice likely occurred as a secondary consequence of cholestasis due to hyperthyroidism, since other causes such as drug-induced or autoimmune liver dysfunction were ruled out. Treatment with methimazole improved severe cholestatic jaundice in parallel with normalization of thyroid function. The mechanism of cholestasis as a secondary complication of hyperthyroidism has not been uncovered and there is no specific biochemical marker for cholestasis due to this hormonal disease at present. This case serves as a reminder that severe jaundice can be a manifestation of simple hyperthyroidism, and that administration of antithyroid drugs is an effective treatment for severe cholestatic jaundice in such cases.

Original languageEnglish
Pages (from-to)315-319
Number of pages5
JournalClinical Journal of Gastroenterology
Volume2
Issue number4
DOIs
Publication statusPublished - 2009 Aug

Fingerprint

Methimazole
Obstructive Jaundice
Hyperthyroidism
Jaundice
Cholestasis
Liver Diseases
Antithyroid Agents
Thyroid Gland
Biomarkers
Therapeutics
Pharmaceutical Preparations

Keywords

  • Cholestatis
  • Hyperthyroidism
  • Jaundice

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Ichikawa, H., Ebinuma, H., Tada, S., Ojiro, K., Yamagishi, Y., Tsukada, N., ... Hibi, T. (2009). A case of severe cholestatic jaundice with hyperthyroidism successfully treated with methimazole. Clinical Journal of Gastroenterology, 2(4), 315-319. https://doi.org/10.1007/s12328-009-0094-8

A case of severe cholestatic jaundice with hyperthyroidism successfully treated with methimazole. / Ichikawa, Hitoshi; Ebinuma, Hirotoshi; Tada, Shinichirou; Ojiro, Keisuke; Yamagishi, Yoshiyuki; Tsukada, Nobuhiro; Hongou, Emi; Funae, Osamu; Irie, Rie; Saito, Hidetsugu; Hibi, Toshifumi.

In: Clinical Journal of Gastroenterology, Vol. 2, No. 4, 08.2009, p. 315-319.

Research output: Contribution to journalArticle

Ichikawa, H, Ebinuma, H, Tada, S, Ojiro, K, Yamagishi, Y, Tsukada, N, Hongou, E, Funae, O, Irie, R, Saito, H & Hibi, T 2009, 'A case of severe cholestatic jaundice with hyperthyroidism successfully treated with methimazole', Clinical Journal of Gastroenterology, vol. 2, no. 4, pp. 315-319. https://doi.org/10.1007/s12328-009-0094-8
Ichikawa, Hitoshi ; Ebinuma, Hirotoshi ; Tada, Shinichirou ; Ojiro, Keisuke ; Yamagishi, Yoshiyuki ; Tsukada, Nobuhiro ; Hongou, Emi ; Funae, Osamu ; Irie, Rie ; Saito, Hidetsugu ; Hibi, Toshifumi. / A case of severe cholestatic jaundice with hyperthyroidism successfully treated with methimazole. In: Clinical Journal of Gastroenterology. 2009 ; Vol. 2, No. 4. pp. 315-319.
@article{68d66282a41d40faa68c68313c243194,
title = "A case of severe cholestatic jaundice with hyperthyroidism successfully treated with methimazole",
abstract = "Liver dysfunction is a common complication observed in patients with hyperthyroidism, however the dysfunction is always mild and obvious jaundice is rarely observed. We present the case of a 43-year-old man who suffered from hyperthyroidism complicated by severe jaundice. The jaundice likely occurred as a secondary consequence of cholestasis due to hyperthyroidism, since other causes such as drug-induced or autoimmune liver dysfunction were ruled out. Treatment with methimazole improved severe cholestatic jaundice in parallel with normalization of thyroid function. The mechanism of cholestasis as a secondary complication of hyperthyroidism has not been uncovered and there is no specific biochemical marker for cholestasis due to this hormonal disease at present. This case serves as a reminder that severe jaundice can be a manifestation of simple hyperthyroidism, and that administration of antithyroid drugs is an effective treatment for severe cholestatic jaundice in such cases.",
keywords = "Cholestatis, Hyperthyroidism, Jaundice",
author = "Hitoshi Ichikawa and Hirotoshi Ebinuma and Shinichirou Tada and Keisuke Ojiro and Yoshiyuki Yamagishi and Nobuhiro Tsukada and Emi Hongou and Osamu Funae and Rie Irie and Hidetsugu Saito and Toshifumi Hibi",
year = "2009",
month = "8",
doi = "10.1007/s12328-009-0094-8",
language = "English",
volume = "2",
pages = "315--319",
journal = "Clinical Journal of Gastroenterology",
issn = "1865-7257",
publisher = "Springer Japan",
number = "4",

}

TY - JOUR

T1 - A case of severe cholestatic jaundice with hyperthyroidism successfully treated with methimazole

AU - Ichikawa, Hitoshi

AU - Ebinuma, Hirotoshi

AU - Tada, Shinichirou

AU - Ojiro, Keisuke

AU - Yamagishi, Yoshiyuki

AU - Tsukada, Nobuhiro

AU - Hongou, Emi

AU - Funae, Osamu

AU - Irie, Rie

AU - Saito, Hidetsugu

AU - Hibi, Toshifumi

PY - 2009/8

Y1 - 2009/8

N2 - Liver dysfunction is a common complication observed in patients with hyperthyroidism, however the dysfunction is always mild and obvious jaundice is rarely observed. We present the case of a 43-year-old man who suffered from hyperthyroidism complicated by severe jaundice. The jaundice likely occurred as a secondary consequence of cholestasis due to hyperthyroidism, since other causes such as drug-induced or autoimmune liver dysfunction were ruled out. Treatment with methimazole improved severe cholestatic jaundice in parallel with normalization of thyroid function. The mechanism of cholestasis as a secondary complication of hyperthyroidism has not been uncovered and there is no specific biochemical marker for cholestasis due to this hormonal disease at present. This case serves as a reminder that severe jaundice can be a manifestation of simple hyperthyroidism, and that administration of antithyroid drugs is an effective treatment for severe cholestatic jaundice in such cases.

AB - Liver dysfunction is a common complication observed in patients with hyperthyroidism, however the dysfunction is always mild and obvious jaundice is rarely observed. We present the case of a 43-year-old man who suffered from hyperthyroidism complicated by severe jaundice. The jaundice likely occurred as a secondary consequence of cholestasis due to hyperthyroidism, since other causes such as drug-induced or autoimmune liver dysfunction were ruled out. Treatment with methimazole improved severe cholestatic jaundice in parallel with normalization of thyroid function. The mechanism of cholestasis as a secondary complication of hyperthyroidism has not been uncovered and there is no specific biochemical marker for cholestasis due to this hormonal disease at present. This case serves as a reminder that severe jaundice can be a manifestation of simple hyperthyroidism, and that administration of antithyroid drugs is an effective treatment for severe cholestatic jaundice in such cases.

KW - Cholestatis

KW - Hyperthyroidism

KW - Jaundice

UR - http://www.scopus.com/inward/record.url?scp=68949205617&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=68949205617&partnerID=8YFLogxK

U2 - 10.1007/s12328-009-0094-8

DO - 10.1007/s12328-009-0094-8

M3 - Article

AN - SCOPUS:68949205617

VL - 2

SP - 315

EP - 319

JO - Clinical Journal of Gastroenterology

JF - Clinical Journal of Gastroenterology

SN - 1865-7257

IS - 4

ER -