A case of squamous cell carcinoma of the lung preceded by pulmonary aspergillosis

Nao Odajima, Koichi Yamazaki, Tomoko Betsuyaku, Masaharu Nishimura

Research output: Contribution to journalArticle


Background. We report a case of squamous cell carcinoma of the lung preceded by pulmonary aspergillosis associated with interstitial pneumonia and diabetes mellitus. Case. An 81-year-old man had a consolidation in his left S9 detected by chest CT in March 2000, which was diagnosed as pulmonary aspergillosis. Despite antifungal therapy with itraconazole, rapid enlargement of the consolidation occured around November 2002. He was refered to our hospital for re-evaluation of the disease in March 2003. Squamous cell lung carcinoma was eventually detected by transbronchial biopsy and left lower lobectomy was performed. The pathological examination of the resected specimen showed aspergillus hyphae in the necrotic cavities of the squamous cell carcinoma, and interstitial pneumonia (nonspecific interstitial pneumonia: NSIP, group 2) was seen around the tumor. We speculate that saprophytic pulmonary aspergillosis occurred in the cysts formed by NSIP, and thereafter squamous cell carcinoma occured. Conclusion. When aspergillus infection is unresponsive to antimycotics, we should keep in mind that lung carcinoma may overlap fungal in-fection.

Original languageEnglish
Pages (from-to)145-150
Number of pages6
JournalJapanese Journal of Lung Cancer
Issue number2
Publication statusPublished - 2005 Apr 1



  • Aspergillus fumigatus
  • Interstitial pneumonia
  • Pulmonary aspergillosis
  • Squamous cell carcinoma

ASJC Scopus subject areas

  • Oncology
  • Pulmonary and Respiratory Medicine

Cite this