A case of squamous cell lung cancer in a nonsmoking female, successfully treated with docetaxel and cisplatin

Koichi Fukunaga, K. Yamaguchi, Ichiro Kawada, T. Inoue, K. Takeshita, Y. Oyamada, Kaori Kameyama, K. Yamazaki

Research output: Contribution to journalArticle

Abstract

A 62-year-old nonsmoking female was admitted to our hospital in May, 1998 complaining of marked cough accompanied by repeated hemosputa. Chest X-ray and CT examinations revealed a large tumor, located adjacent to a cystic lesion in the left lower lung field, in association with a clearly recognizable swelling of the ipsilateral hilar as well as the mediastinal lymph nodes. Sputum cytology after bronchofiberscopy led to the diagnosis that the patient suffered from squamous cell lung cancer of Stage IIIA with bulky N2 (T2N2M0). Chemotherapy was selected as the most reasonable treatment for this patient. The new chemotherapeutic agent docetaxel (60 mg/m2) in combination with cisplatin (CDDP: 80 mg/m2) was tried, resulting in a remarkable reduction in tumor size by 60% after the initial course of chemotherapy was completed, which fulfilled the definition of a partial response (PR). Furthermore, after 4 courses of the chemotherapy, the hilar and mediastinal lymphadenopathy had conspicuously abated and only scar tissue was visible at the site where the lung cancer was thought to have originally developed. We herein report a case in which squamous cell lung cancer sprouted in a nonsmoking female, who was successfully treated by the combined chemotherapy of docetaxel and CDDP. The present case may suggest the efficacy of newly developed docetaxel in treating non-small cell lung cancer.

Original languageEnglish
Pages (from-to)139-142
Number of pages4
JournalJapanese Journal of Cancer and Chemotherapy
Volume27
Issue number1
Publication statusPublished - 2000 Jan

Fingerprint

docetaxel
Squamous Cell Neoplasms
Cisplatin
Lung Neoplasms
Drug Therapy
X Ray Computed Tomography
Sputum
Cough
Non-Small Cell Lung Carcinoma
Cicatrix
Cell Biology
Neoplasms
Thorax
Lymph Nodes
Lung

ASJC Scopus subject areas

  • Cancer Research
  • Pharmacology

Cite this

A case of squamous cell lung cancer in a nonsmoking female, successfully treated with docetaxel and cisplatin. / Fukunaga, Koichi; Yamaguchi, K.; Kawada, Ichiro; Inoue, T.; Takeshita, K.; Oyamada, Y.; Kameyama, Kaori; Yamazaki, K.

In: Japanese Journal of Cancer and Chemotherapy, Vol. 27, No. 1, 01.2000, p. 139-142.

Research output: Contribution to journalArticle

@article{7d9a5ab7bd534049862db99da48029f7,
title = "A case of squamous cell lung cancer in a nonsmoking female, successfully treated with docetaxel and cisplatin",
abstract = "A 62-year-old nonsmoking female was admitted to our hospital in May, 1998 complaining of marked cough accompanied by repeated hemosputa. Chest X-ray and CT examinations revealed a large tumor, located adjacent to a cystic lesion in the left lower lung field, in association with a clearly recognizable swelling of the ipsilateral hilar as well as the mediastinal lymph nodes. Sputum cytology after bronchofiberscopy led to the diagnosis that the patient suffered from squamous cell lung cancer of Stage IIIA with bulky N2 (T2N2M0). Chemotherapy was selected as the most reasonable treatment for this patient. The new chemotherapeutic agent docetaxel (60 mg/m2) in combination with cisplatin (CDDP: 80 mg/m2) was tried, resulting in a remarkable reduction in tumor size by 60{\%} after the initial course of chemotherapy was completed, which fulfilled the definition of a partial response (PR). Furthermore, after 4 courses of the chemotherapy, the hilar and mediastinal lymphadenopathy had conspicuously abated and only scar tissue was visible at the site where the lung cancer was thought to have originally developed. We herein report a case in which squamous cell lung cancer sprouted in a nonsmoking female, who was successfully treated by the combined chemotherapy of docetaxel and CDDP. The present case may suggest the efficacy of newly developed docetaxel in treating non-small cell lung cancer.",
author = "Koichi Fukunaga and K. Yamaguchi and Ichiro Kawada and T. Inoue and K. Takeshita and Y. Oyamada and Kaori Kameyama and K. Yamazaki",
year = "2000",
month = "1",
language = "English",
volume = "27",
pages = "139--142",
journal = "Japanese Journal of Cancer and Chemotherapy",
issn = "0385-0684",
publisher = "Japanese Journal of Cancer and Chemotherapy Publishers Inc.",
number = "1",

}

TY - JOUR

T1 - A case of squamous cell lung cancer in a nonsmoking female, successfully treated with docetaxel and cisplatin

AU - Fukunaga, Koichi

AU - Yamaguchi, K.

AU - Kawada, Ichiro

AU - Inoue, T.

AU - Takeshita, K.

AU - Oyamada, Y.

AU - Kameyama, Kaori

AU - Yamazaki, K.

PY - 2000/1

Y1 - 2000/1

N2 - A 62-year-old nonsmoking female was admitted to our hospital in May, 1998 complaining of marked cough accompanied by repeated hemosputa. Chest X-ray and CT examinations revealed a large tumor, located adjacent to a cystic lesion in the left lower lung field, in association with a clearly recognizable swelling of the ipsilateral hilar as well as the mediastinal lymph nodes. Sputum cytology after bronchofiberscopy led to the diagnosis that the patient suffered from squamous cell lung cancer of Stage IIIA with bulky N2 (T2N2M0). Chemotherapy was selected as the most reasonable treatment for this patient. The new chemotherapeutic agent docetaxel (60 mg/m2) in combination with cisplatin (CDDP: 80 mg/m2) was tried, resulting in a remarkable reduction in tumor size by 60% after the initial course of chemotherapy was completed, which fulfilled the definition of a partial response (PR). Furthermore, after 4 courses of the chemotherapy, the hilar and mediastinal lymphadenopathy had conspicuously abated and only scar tissue was visible at the site where the lung cancer was thought to have originally developed. We herein report a case in which squamous cell lung cancer sprouted in a nonsmoking female, who was successfully treated by the combined chemotherapy of docetaxel and CDDP. The present case may suggest the efficacy of newly developed docetaxel in treating non-small cell lung cancer.

AB - A 62-year-old nonsmoking female was admitted to our hospital in May, 1998 complaining of marked cough accompanied by repeated hemosputa. Chest X-ray and CT examinations revealed a large tumor, located adjacent to a cystic lesion in the left lower lung field, in association with a clearly recognizable swelling of the ipsilateral hilar as well as the mediastinal lymph nodes. Sputum cytology after bronchofiberscopy led to the diagnosis that the patient suffered from squamous cell lung cancer of Stage IIIA with bulky N2 (T2N2M0). Chemotherapy was selected as the most reasonable treatment for this patient. The new chemotherapeutic agent docetaxel (60 mg/m2) in combination with cisplatin (CDDP: 80 mg/m2) was tried, resulting in a remarkable reduction in tumor size by 60% after the initial course of chemotherapy was completed, which fulfilled the definition of a partial response (PR). Furthermore, after 4 courses of the chemotherapy, the hilar and mediastinal lymphadenopathy had conspicuously abated and only scar tissue was visible at the site where the lung cancer was thought to have originally developed. We herein report a case in which squamous cell lung cancer sprouted in a nonsmoking female, who was successfully treated by the combined chemotherapy of docetaxel and CDDP. The present case may suggest the efficacy of newly developed docetaxel in treating non-small cell lung cancer.

UR - http://www.scopus.com/inward/record.url?scp=0033631147&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033631147&partnerID=8YFLogxK

M3 - Article

C2 - 10660748

AN - SCOPUS:0033631147

VL - 27

SP - 139

EP - 142

JO - Japanese Journal of Cancer and Chemotherapy

JF - Japanese Journal of Cancer and Chemotherapy

SN - 0385-0684

IS - 1

ER -