A case report: Severe bone marrow suppression caused by 6-mercaptopurin in Crohn's disease patient

Daisuke Kubota, Chizuru Takishima, Ken Ishii, Takahiro Kawamura, Tomoko Matsumoto, Yasuhiro Itsui, Eriko Okada, Seishin Chin, Shinya Oooka, Kiichiro Tsuchiya, Akihiro Araki, Naoya Sakamoto, Tatsuya Miyata, Takanori Kanai, Mamoru Watanabe

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Abstract

A 23-year-old man was admitted for treatment of acute exacerbation of ileitis and perianal abscess caused by Crohn's disease. After incision and drainage of the abscess, coupled with antibiotic therapy, 6-mercaptopurine (6-MP) was commenced. His white blood cell (WBC) count on day 12 after initiation of 6-MP was not decreased. However, on day 24 he was re-admitted because of severe myelosuppression (WBC: 300/μl), which was complicated by the recurrence of the perianal abscess. Myelosuppression was prolonged and required the administration of granulocyte colony stimulating factor (G-CSF). G-CSF was continued for 17 days to achieve recovery of his WBC count to a normal level.

Original languageEnglish
Pages (from-to)1044-1049
Number of pages6
JournalJapanese Journal of Gastroenterology
Volume103
Issue number9
Publication statusPublished - 2006 Sep 1
Externally publishedYes

ASJC Scopus subject areas

  • Gastroenterology

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  • Cite this

    Kubota, D., Takishima, C., Ishii, K., Kawamura, T., Matsumoto, T., Itsui, Y., Okada, E., Chin, S., Oooka, S., Tsuchiya, K., Araki, A., Sakamoto, N., Miyata, T., Kanai, T., & Watanabe, M. (2006). A case report: Severe bone marrow suppression caused by 6-mercaptopurin in Crohn's disease patient. Japanese Journal of Gastroenterology, 103(9), 1044-1049.