A centrifuge-based droplet shooting device for the synthesis of multi-compartmental microspheres under ultra-high gravity

Kazuki Maeda, Masahiro Takinoue, Hiroaki Onoe, Shoji Takeuchi

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

This paper reports the centrifuge-based synthesis method of monodisperse hydrogel microspheres possessing multiple compartments under ultra-high centrifugal gravity, and the demonstration of magnetic self-assembly of chain-structures using cellladen Janus-spheres. Our method, enabling gelification of droplets of sodium alginate solution into microparticles without oil, heat or UV, is easy to use, simple and biocompatible. The synthesis procedure takes only a few minutes and can be conducted on a lab-bench, using our Centrifuge-based Droplet Shooting Device (CDSD) and a tabletop centrifuge. The CDSD will be a valuable tool in various fields, such as drug delivery, biotechnology and tissue engineering.

Original languageEnglish
Title of host publication15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011
Pages12-14
Number of pages3
Publication statusPublished - 2011 Dec 1
Event15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011 - Seattle, WA, United States
Duration: 2011 Oct 22011 Oct 6

Publication series

Name15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011
Volume1

Other

Other15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011
CountryUnited States
CitySeattle, WA
Period11/10/211/10/6

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Keywords

  • Anisotropic particle
  • Centrifuge
  • Hydrogel
  • Microfluidics

ASJC Scopus subject areas

  • Control and Systems Engineering

Cite this

Maeda, K., Takinoue, M., Onoe, H., & Takeuchi, S. (2011). A centrifuge-based droplet shooting device for the synthesis of multi-compartmental microspheres under ultra-high gravity. In 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011 (pp. 12-14). (15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011; Vol. 1).